Results 251 to 260 of about 2,037,182 (315)

Rab1A Promotes Hepatic Steatosis by Suppressing Mitophagy via the Raf‐1/ERK1/2/PINK1 Signaling Axis

Advanced Science, EarlyView.
Why does fat accumulate in the liver? Our study reveals Rab1A as the molecular switch that silences the cell's mitochondrial cleanup crew. Turning Rab1A off reactivates mitophagy, clears excess fat, and reverses fatty liver disease in mice—offering a promising new therapeutic target for MASLD, a growing global health challenge.
Li Zhang, Jianhua Li, Huilu Zhang, Qi Qin, Yichen Huang, Xiaofan Tian, Chao Sun, Binbin Li, Zhengxin Wang, Xin Zhang   +9 more
wiley   +1 more source

Attomolar Detection of HIV‐1 With Label‐Free RCA‐rCRISPR on Smartphone

Advanced Science, EarlyView.
A new diagnostic strategy integrating rolling circle amplification (RCA) with a plasmid reporter–based ratiometric CRISPR (rCRISPR) system was developed to detect unfragmented HIV genomes with single‐digit attomolar sensitivity. The method quantifies targets using the plasmid relaxation ratio and employs a smartphone‐based mini‐gel device to enable ...
Noor Mohammad, Anastasiia Steksova, Yuyang Tang, Leyao Huang, Alireza Velayati, Shengwei Zhang, Aditi Dey Poonam, Sina Jamalzadegan, Matthew Breen, Hongjie Chen, Mahsa Bagi, Guochun Jiang, Qingshan Wei   +12 more
wiley   +1 more source

Recombinant Antibody Vaccines for Targeted Antigen Delivery: Design Principles and Immunological Applications. [PDF]

Vaccines (Basel)
Pirogovsky KM, Hawiger D.
europepmc   +1 more source

Identification of Serum Antibodies Cross-Reactive with Pathogenic Betacoronavirus Amongst Rural Communities Within the Forested Region of the Republic of Guinea. [PDF]

Viruses
Tipton TRW, Bore JA, Timothy J, Longet S, Laidlaw SM, Hood G, Thompson C, Mellors J, Kekoura I, Lucien MS, Koivogui BK, Zeze K, Matthews D, Davidson AD, Mentzer A, Skelly D, Klenerman P, Hiscox J, Magassouba N, Fornace K, Carroll MW.   +20 more
europepmc   +1 more source

Dataset on the evaluation of an ELISA assay using Yersinia pseudotuberculosis O-antigen for serodiagnosis in comparison with agglutination antibody test. [PDF]

Data Brief
Izumiya H, Nakajima H, Kawakami Y, Kawase J, Akeda Y.   +4 more
europepmc   +1 more source

Current Strategies for Selecting Recombinant Orthopoxvirus Proteins for Immunobiological and Diagnostic Applications. [PDF]

Viruses
Zhakypbek A, Kutumbetov L, Kuzembekova G, Shorayeva K, Kozhabergenov N, Usserbayev B, Nakhanova G, Jekebekov K, Shynybekova G, Abdykalyk A, Ulankyzy A, Baiseit T, Myrzakhmetova B, Chervyakova O, Zhugunissov K.   +14 more
europepmc   +1 more source