Results 31 to 40 of about 37,241 (266)

Molecular mechanism of antihistamines recognition and regulation of the histamine H1 receptor

Nature Communications
Histamine receptors are a group of G protein-coupled receptors (GPCRs) that play important roles in various physiological and pathophysiological conditions.
Dandan Wang, Qiong Guo, Zhangsong Wu, Ming Li, Binbin He, Yang Du, Kaiming Zhang, Yuyong Tao   +7 more
doaj   +1 more source

Tezepelumab in Chinese Patients With Severe Chronic Rhinosinusitis With Nasal Polyps: A Prespecified Subgroup Analysis of the Phase 3 WAYPOINT Trial

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis with nasal polyps (CRSwNP) in Chinese patients often exhibits a mixed Type 1/2/3 inflammatory phenotype (63%), potentially impacting the efficacy of biologics targeting Type 2 inflammation. This prespecified subgroup analysis of WAYPOINT (NCT04851964) evaluated the efficacy and safety of tezepelumab in Chinese
Li Hu, Houyong Li, Xicai Sun, Quan Liu, Yu Xu, Jiangang Fan, Andrew Foster, Claudia Chen, Yun Chon, Dehui Wang   +9 more
wiley   +1 more source

Systematic review about 10 interventions in dermatitis. A document from the Latin American Society of Allergy, Asthma, and Immunology

Revista Alergia México, 2019
The Latin American Society of Allergy, Asthma, and Immunology (SLAAI) conducted a systematic search in the Medline and LILACS’ database in order to get articles linked to 10 current questions about dermatitis.
Jorge Sánchez, Mario Roberto Sánchez, Alejandra Macías-Weinmann, Bruno Barreto, Luis Felipe Ensina, Silvia Antonieta Uriarte-Obando, Raúl Lázaro Castro-Almarales, Romina Adorni, Milagros Lázaro, Ariel Callero-Viera, Iris Ale, Leidy Álvarez   +11 more
doaj   +1 more source

Anomeric Amide Enabled Divergent Synthesis of Unsymmetrical Ureas, Carbamates, Thioesters, and Amides From Aldehydes

Angewandte Chemie International Edition, EarlyView.
An anomeric amide‐enabled divergent aldehyde functionalization sequence provides one‐pot access to unsymmetrical ureas, carbamates, thiocarbamates, thioesters, and amides. Key to this transformation is the formation of N‐Boc‐hydroxamate intermediates, which serve as platforms for orthogonal activation via Lossen‐type rearrangements, single‐electron ...
Jasper L. Tyler, Meiyi Zeng, Julius Wiener, Marie‐Christin Leusmann, Colin Stein, Constantin G. Daniliuc, Frank Glorius   +6 more
wiley   +1 more source

Efficacy and Safety of Nanoencapsulated Sirolimus Plus Pegadricase: Results From the Randomized, Placebo‐Controlled Phase 3 Trials

Arthritis &Rheumatology, EarlyView.
Objective DISSOLVE I and II examined the efficacy and safety of nanoencapsulated sirolimus (NAS) plus pegadricase (NASP) in patients with uncontrolled gout (UG). Methods In these double‐blind, placebo‐controlled Phase 3 trials of NASP, patients were randomized 1:1:1 to infusions of high‐dose (HD) or low‐dose (LD) NAS plus pegadricase (HD NASP, LD NASP,
Herbert S. B. Baraf, Puja P. Khanna, Milan Petronijevic, Mamuka Lortkipanidze, Anand Patel, Kwabena Ayesu, Michael H. Pillinger, Atul Singhal, Joanna Sobierska, Jacquie Christie, Peter Traber, Rehan Azeem, Wesley DeHaan, Hugues Santin‐Janin, Bhavisha Desai, Alan Kivitz   +15 more
wiley   +1 more source

Allergic Rhinitis in Childhood and the New EUFOREA Algorithm

Frontiers in Allergy, 2021
Allergic rhinitis in childhood has been often missed, mistreated and misunderstood. It has significant comorbidities, adverse effects upon quality of life and educational performance and can progress to asthma or worsen control of existing asthma ...
Glenis Kathleen Scadding, Glenis Kathleen Scadding, Peter Kenneth Smith, Michael Blaiss, Graham Roberts, Graham Roberts, Graham Roberts, Peter William Hellings, Peter William Hellings, Philippe Gevaert, Marinda Mc Donald, Tania Sih, Suzanne Halken, Petra Ursula Zieglmayer, Petra Ursula Zieglmayer, Peter Schmid-Grendelmeier, Erkka Valovirta, Ruby Pawankar, Ulrich Wahn   +18 more
doaj   +1 more source

Navigating adverse immunostimulation: A practical guide for clinical researchers

British Journal of Clinical Pharmacology, EarlyView.
Problem Setting As drug development moves towards more complex products, early clinical development programmes are increasingly hampered by unwanted and/or unexpected activation of the immune system (adverse immune stimulation, AIS). Solution At the Centre for Human Drug Research, we have introduced standardized procedures to make AIS manageable, while
Juliette A. van den Noort, Anouk C. Meijs, Naomi B. Klarenbeek, Matthijs Moerland   +3 more
wiley   +1 more source

Infusion rate adjustment in enzyme replacement therapy with pabinafusp alfa for mucopolysaccharidosis II

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Enzyme replacement therapy (ERT) for mucopolysaccharidosis II (MPS II) requires long‐term, weekly intravenous infusions often lasting over 3 h each time, which can burden paediatric patients and caregivers and negatively affect their quality of life and treatment compliance.
Kimitoshi Nakamura, Norio Sakai, Hideaki Hirai, Naoko Takasao, Ryo Ibaraki, Tatsuyoshi Yamamoto, Yuji Sato   +6 more
wiley   +1 more source

Use of second-generation antihistamines in combination treatment of ENT diseases

Медицинский совет, 2015
Currently, allergic diseases are very widespread, and their incidence is increasing at an alarming pace worldwide. [1] According to different authors, from 20 to 50% of the population in European countries suffer from allergic diseases.
A. I. Kryukov, N. L. Kunelskaya, G.Y. T Tsarapkin, G. N. Izotova, S. G. Arzamazov, A. S. Tovmasyan   +5 more
doaj   +1 more source

Primary Non-Adherence to Antihistamines—Conclusions From E-Prescription Pilot Data in Poland

Frontiers in Pharmacology, 2020
BackgroundIn allergic conditions such as allergic rhinitis and urticaria, orally administered H1-antihistamines belong to first-line therapy and therefore, are widely prescribed.
Grzegorz Kardas, Michał Panek, Piotr Kuna, Janusz Cieszyński, Przemysław Kardas   +4 more
doaj   +1 more source