Results 81 to 90 of about 4,370 (170)

Discovery of Potential Antileishmanial Compounds Through Phenotypic Screening of an Alkaloid Library

Molecules
Visceral leishmaniasis caused by Leishmania donovani is one of the major neglected tropical diseases attributable to parasitic protozoa. In the absence of an effective vaccine, chemotherapy remains the only available therapeutic option.
Cathy Soh-Kamdjo, María-Cristina González-Montero, Carlos García-Estrada, Estela Melcón-Fernández, Celia Fernández-Rubio, Yolanda Pérez-Pertejo, Rosa M. Reguera, Rafael Balaña-Fouce   +7 more
doaj   +1 more source

Isolation of potent antileishmanial agents from Artemisia kermanensis Podlech using bioguided fractionation. [PDF]

J Parasit Dis, 2023
Soleimanifard S, Saeedi S, Yazdiniapour Z.   +2 more
europepmc   +1 more source

Evolution of Acridines and Xanthenes as a Core Structure for the Development of Antileishmanial Agents. [PDF]

Pharmaceuticals (Basel), 2022
Silva CFM, Pinto DCGA, Fernandes PA, Silva AMS.   +3 more
europepmc   +1 more source

Pyrimido[5,4-d]pyrimidine-Based Compounds as a Novel Class of Antitrypanosomal and Antileishmanial Agents. [PDF]

ACS Med Chem Lett, 2022
Lopes A, Santarém N, Cordeiro-da-Silva A, Carvalho MA.   +3 more
europepmc   +1 more source

Phenotypic investigation of 4-nitrophenylacetyl- and 4-nitro-1H-imidazoyl-based compounds as antileishmanial agents. [PDF]

Parasitology, 2022
Santos CC, Zhang H, Batista MM, de Oliveira GM, Demarque KC, da Silva NL, Moreira OC, Ogungbe IV, Soeiro MNC.   +8 more
europepmc   +1 more source

Approved drugs successfully repurposed against Leishmania based on machine learning predictions

Frontiers in Cellular and Infection Microbiology
Drug repurposing is a promising approach towards the discovery of novel treatments against Neglected Tropical Diseases, such as Leishmaniases, presenting the advantage of reducing both costs and duration of the drug discovery process.
Rafeh Oualha, Yosser Zina Abdelkrim, Ikram Guizani, Emna Harigua-Souiai   +3 more
doaj   +1 more source

Amino-Substituted 3-Aryl- and 3-Heteroarylquinolines as Potential Antileishmanial Agents. [PDF]

J Med Chem, 2021
Hammill JT, Sviripa VM, Kril LM, Ortiz D, Fargo CM, Kim HS, Chen Y, Rector J, Rice AL, Domagalska MA, Begley KL, Liu C, Rangnekar VM, Dujardin JC, Watt DS, Landfear SM, Guy RK.   +16 more
europepmc   +1 more source

Identification of 2-arylquinazolines with alkyl-polyamine motifs as potent antileishmanial agents: synthesis and biological evaluation studies. [PDF]

RSC Med Chem, 2022
Kumari A, Jaiswal T, Kumar V, Hura N, Kumar G, Babu NK, Acharya A, Roy PK, Guchhait SK, Singh S.   +9 more
europepmc   +1 more source

Contribution of epidermal growth factor (EGF) in the treatment of cutaneous leishmaniasis caused by Leishmania major in BALB/c mice.

PLoS Neglected Tropical Diseases
Cutaneous leishmaniasis (CL) is a tropical disease that can cause chronic lesions and leave life-long scars, leading to social stigmatization and psychological disorders.
Mohammad Saberi, Alireza Latifi, Majid Golkar, Pezhman Fard-Esfahani, Sina Mohtasebi, Aref Teimouri, Mohammad Javad Abbaszadeh Afshar, Elham Kazemirad, Mehdi Mohebali   +8 more
doaj   +1 more source

Bioassay-guided isolation of leishmanicidal cucurbitacins from Momordica charantia

Frontiers in Pharmacology
IntroductionLeishmaniasis, a neglected tropical parasitic disease, is regarded as a major public health problem worldwide. The first-line drugs for leishmaniasis suffer from limitations related to toxicity and the development of resistance in certain ...
Maria Carolina Silva Marques, Nídia Cristiane Yoshida, Eduardo Caio Torres-Santos, Fernanda Rodrigues Garcez, Walmir Silva Garcez   +4 more
doaj   +1 more source