Results 71 to 80 of about 4,370 (170)

Monodentate Phosphine Modulation in Cyclometallated Platinum(II) Complexes for Antileishmanial, Antiviral, and Antitumor Applications

ChemMedChem, Volume 21, Issue 4, 25 February 2026.
Schematic representation depicting the influence of phosphine ligand identity on the biological and physicochemical characteristics of Pt(II) complexes: PTA promotes antileishmanial activity, PPh2(Php–COOH) strengthens antiviral activity, and TCEP enhances fluorescence.
Antonio A. de Oliveira‐Neto, Gustavo Clauss, Jennyfer Castro, Marcus S. A. Garcia, Natasha M. Cassani, Bruna C. Sandim, Ana Laura C. Oliveira, Stephanie P. B. Reyes, Nádija N. P. da Silva, Fillipe V. Rocha, Ana C. G. Jardim, Danilo C. Miguel, Camilla Abbehausen   +12 more
wiley   +1 more source

Progress in antileishmanial drugs: Mechanisms, challenges, and prospects.

PLoS Neglected Tropical Diseases
Leishmaniasis, a neglected tropical disease caused by Leishmania parasites, continues to pose global health challenges. Current treatments face issues like resistance, safety, efficacy, and cost.
Haoran Zhang, Ruixi Yan, Yahui Liu, Mengtao Yu, Ziyi He, Junfeng Xiao, Kaijie Li, Gang Liu, Qin Ning, Yan Li   +9 more
doaj   +1 more source

Divulging the Antimicrobial and Antidiabetic Potential of Bombax ceiba L.

Journal of Bioresource Management, 2017
Current study is intended to investigate the antimicrobial and antidiabetic potential of Bombax ceiba L. Antileishmanial potential was assessed via MTT colorimetric method while antifungal activities were found out through disc diffusion method.
Hafiz Tahsin Ullah Jan, Syeda Saniya Zahra , Bakht Nasir , Muhammad Waleed Baig , Madiha Ahmed   +4 more
doaj   +1 more source

Could the Biological Potency of Porcelia macrocarpa R.E. Fries (Annonaceae) be Linked to Its Diverse Metabolite Profile?

Chemistry &Biodiversity, Volume 23, Issue 1, January 2026.
ABSTRACT Porcelia macrocarpa is a Brazilian plant species belonging to the Annonaceae family. To date, more than 190 compounds have been identified and/or isolated from this species, with terpenoids comprising the majority (62%). Alkaloids represent the second most abundant class (11%), followed by steroids (4%), acetogenins (4%), fatty acids (4 ...
Fernanda Thevenard, Ivanildo A. Brito, Emerson A. Oliveira, Mariana H. Chaves, João Henrique G. Lago   +4 more
wiley   +1 more source

Silk Fibroin‐Stabilized Lapachol Microemulsion Enhances Antiglioma Activity In Vitro

Chemistry &Biodiversity, Volume 23, Issue 1, January 2026.
Silk fibroin‐stablized lapachol microformulation antiglioma activity. ABSTRACT Gliomas are the most prevalent of the brain tumors, and are associated with high mortality and limited therapeutic options. This study introduces, for the first time, a silk fibroin (SF)‐based microemulsion as a nanocarrier for lapachol (LP).
Jardel P. Queiroz, Fábio R. Oliveira, Eline Gomes Santos, Fabrício Holanda, Victor Marinho, Edilene Oliveira da Silva, José Carlos T. Carvalho, Caio P. Fernandes, Barbarella M. Macchi, Irlon M. Ferreira, José Luiz M. Nascimento   +10 more
wiley   +1 more source

Quantification of Nitric Oxide and Reactive Oxygen Species in Leishmania-infected J774A.1 Macrophages as a Response to the in vitro Treatment with a Natural Product Compound

Bio-Protocol, 2019
Leishmaniasis is a parasitic disease caused by the obligatory intracellular protozoa Leishmania spp. Current therapeutic options are limited and thus, drug discovery against leishmaniasis is very important.
Kalliopi Karampetsou, Olga Koutsoni, Eleni Dotsika   +2 more
doaj   +1 more source

Quinolines: the role of substitution site in antileishmanial activity

Frontiers in Chemistry
Leishmaniasis is one of the most widespread parasitic diseases in the world, primarily affecting the poorest and most vulnerable populations. The development of new therapeutic agents that are more efficient, safe, and selective remains a challenge.
Orlando G. Elso, Guadalupe García Liñares   +1 more
doaj   +1 more source

In-Vitro Activity of Silybin and Related Flavonolignans against Leishmania infantum and L. donovani

Molecules, 2018
Flavonolignans from the seeds of the milk thistle (Silybum marianum) have been extensively used in folk medicine for centuries. Confirmation of their properties as hepatoprotective, antioxidant and anticancer has been obtained using standardized extracts
Ana Isabel Olías-Molero, María Dolores Jiménez-Antón, David Biedermann, María J. Corral, José María Alunda   +4 more
doaj   +1 more source

Evolution of the Quinoline Scaffold for the Treatment of Leishmaniasis: A Structural Perspective

Pharmaceuticals
Since the beginning of the XXI century, Leishmaniasis has been integrated into the World Health Organization’s list of the 20 neglected tropical diseases, being considered a public health issue in more than 88 countries, especially in the tropics ...
Carlos F. M. Silva, Diana C. G. A. Pinto, Pedro A. Fernandes, Artur M. S. Silva   +3 more
doaj   +1 more source

Anti-leishmanial activity and dereplication using GC-MS assisted by molecular networking of the essential oil from the leaves and inflorescence of Melaleuca viminalis (myrtaceae)

Frontiers in Natural Products
IntroductionThe urgent need for new antileishmanial agents is driven by the toxicity and emerging resistance associated with current therapies. Essential oils from Melaleuca viminalis (Myrtaceae) are rich in bioactive monoterpenes; however, integrated ...
Ana Clara L. N. Silva, Marisi G. Soares, Eduard Choi Jr., Gabriela V. Araujo Flores, Gabriela V. Araujo Flores, Luiz Felipe D. Passero, Luiz Felipe D. Passero, Márcia D. Laurenti, Patrícia Sartorelli   +8 more
doaj   +1 more source