Results 51 to 60 of about 4,370 (170)

A New Macrolactone, Racemolide Along With Seven Known Compounds With Biological Activities From Mangrove Plant,

Natural Product Communications, 2019
One new macrolide, racemolide ( 1 ), was isolated from an MeOH extract of the leaves of Lumnitzera racemosa with 7 known compounds ( 2-8 ) by various chromatographic techniques via silica gel, octadecylsilyl column chromatography and high-performance ...
Ahmed Gomaa Gomaa Darwish, Mamdouh Nabil Samy, Sachiko Sugimoto, Hideaki Otsuka, Katsuyoshi Matsunami   +4 more
doaj   +1 more source

In Vitro Evaluation of Antileishmanial Activity of Commiphora myrrha Essential Oil Nanoliposome

Veterinary Medicine and Science, Volume 12, Issue 3, May 2026.
This study investigates the efficacy of nanoliposomal formulations containing myrrh essential oil in combating Leishmania protozoa in laboratory settings. Myrrh essential oil and nanoliposomes were prepared in RPMI‐1640 medium at concentrations of 1, 2, 5 and 10 µg/dL.
Zahra Akbari, Mohammad Reza Youssefi, Mohaddeseh Abouhosseini Tabari   +2 more
wiley   +1 more source

Determination of essential oil composition of Laurencia obtusa and Ceramium spp. in Black Sea and antileishmanial activity

International Journal of Secondary Metabolite
In this study, the chemical compositions of volatile oils obtained via Clevenger distillation from red algae species Laurencia obtusa and Ceramium spp., collected from the coastal areas of Sinop (Black Sea), were analyzed by GC/MS.
Tayyibe Beyza Yücel, Seda Fandaklı, Ulku Karaman, Şahin Direkel   +3 more
doaj   +1 more source

Late‐Stage Diversification of Pyrazoles as Antileishmanial Agents

ChemMedChem
AbstractN‐Pyrazolylcarboxamides and N‐pyrazolylureas represent promising lead compounds for the development of novel antileishmanial drugs. Herein, we report the late‐stage diversification of 3‐bromopyrazoles 10 A/B and 14 A by Pd‐catalyzed Sonogashira and Suzuki‐Miyaura cross coupling reactions.
Tobias Winge, Ben Perry, An Matheeussen, Guy Caljon, Bernhard Wünsch   +4 more
openaire   +3 more sources

In Vitro Antitrypanosomal and Antibacterial Activity of Aqueous, Hydroethanolic and Ethanolic Extracts of Rumex obtusifolius L. Leaf and Root

Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 5, May 2026.
ABSTRACT Plant extracts are an important raw material for the development of new drugs. Rumex obtusifolius L., popularly known as ‘bitter dock’, has significant pharmacological properties. This study evaluated the in vitro antitrypanosomal activity of aqueous, hydroethanolic and ethanolic extracts from the leaf and roots of R. obtusifolius L.
Gabriela K. Borges, Gabriella B. Das Neves, Letícia Reichardt, Ubirajara Maciel da Costa, Luiz C. Miletti, Amanda L. Bastos‐Pereira   +5 more
wiley   +1 more source

Peptides as a Therapeutic Alternative Against Leishmaniasis: A Scoping Review

Chemical Biology &Drug Design, Volume 107, Issue 5, May 2026.
This scoping review of 79 studies identified 231 antimicrobial peptides with anti‐Leishmania activity, including natural‐derived and synthetic peptides (inspired by natural sources or developed through rational design). Most were evaluated in vitro against promastigote and/or amastigote forms, with synthetic peptides showing a more promising effect ...
Maria Eduarda da Veiga Oliveira, Ellen Dyminski Parente Ribeiro, Otávio Henrique Pradi Guenther, Fernanda Tomiotto‐Pellissier   +3 more
wiley   +1 more source

New Thieno[3,2-d]pyrimidin-4(3H)-one Schiff Bases as Selective Antileishmanial Agents

Life
The present study aimed to design, synthesize, and evaluate a new series of thieno[3,2-d]pyrimidin-4(3H)-one-based Schiff bases as potential antileishmanial agents against Leishmania major (L. major).
Neriman Mor, Barış Yıldız, Baycan Mor, Feyzi Sinan Tokalı   +3 more
doaj   +1 more source

Multimodal Cross‐Attentive Graph‐Based Framework for Predicting In Vivo Endocrine Disruptors

Advanced Science, Volume 13, Issue 21, 13 April 2026.
A multimodal cross‐attentive graph neural network integrates molecular graphs with androgen and estrogen adverse outcome pathway (AOP)–anchored in vitro assay signals to predict in vivo endocrine disruption. By fusing information on Tier‐1 AOP logits with chemical structures, the framework achieves high accuracy and provides assay‐traceable ...
Eder Soares de Almeida Santos, Gustavo Felizardo Santos Sandes, Artur Christian Garcia da Silva, Holli‐Joi Martin, Eugene N. Muratov, Rodolpho de Campos Braga, Bruno Junior Neves   +6 more
wiley   +1 more source

Antileishmanial in vitro activity of essential oil from Myrciaria plinioides, a native species from Southern Brazil

Brazilian Journal of Pharmaceutical Sciences, 2019
In South American folk medicine members of the genus Myrciaria are used for the treatment of malaria, diarrhoea, asthma, inflammation and post-partum uterine cleansing.
Carla Kauffmann, Ana Caroline Giacomin, Kelen Arossi, Leandra Andressa Pacheco, Lucélia Hoehne, Elisete Maria de Freitas, Gérzia Maria de Carvalho Machado, Marilene Marcuzzo do Canto Cavalheiro, Simone Cristina Baggio Gnoatto, Eduardo Miranda Ethur   +9 more
doaj   +1 more source

Alternative Approaches and Plant‐Based Remedies for Livestock Health Management Among the Batswana of Southern Africa: A Review

Chemistry &Biodiversity, Volume 23, Issue 4, April 2026.
ABSTRACT Due to limited access to, and the high cost of conventional veterinary services, Batswana communities often rely on ethnoveterinary practices for livestock health management. This review provides an in‐depth analysis on the ethnoveterinary uses, biological properties and safety assessment of plants utilised in livestock husbandry. A systematic
Tswelelopele G. Mpolokeng, Ndzalama Shikwambana, Mompati V. Chakale, John A. Asong, Lyndy J. McGaw, Stephen O. Amoo, Nqobile A. Masondo, Adeyemi O. Aremu   +7 more
wiley   +1 more source