Results 31 to 40 of about 4,370 (170)

Synthesis and biological evaluation of 9-aryl-1,8-dioxo-octahydroxanthene derivatives as antileishmanial agents

Results in Chemistry, 2023
In the current research, we designed and synthesized various derivatives of 9-aryl-1,8-dioxo-octahydroxanthene using flow chemistry technique and explored in vitro study for antileishmanial activity against the promastigote as well as amastigote form of ...
Kamlesh Lodha, Deepak Wavhal, Namdeo Bhujbal, Priyanka Mazire, Sneha Bhujbal, Ashlesha Korde, Kamini Bagul, Amit Roy, Rohan Meshram, Vaishali Shinde   +9 more
doaj   +1 more source

Antiparasitic and cytotoxicity effects of 7-hydroxy-4′- methoxy isoflavone against Leishmania major [PDF]

Journal of HerbMed Pharmacology, 2023
Introduction: Leishmaniasis caused by Leishmania spp. is observed in most parts of the world. Although, glucantime, a pentavalent antimony compound, and other synthetic drugs are broadly applied for leishmaniasis therapy; however, the use of these ...
Mahdi Aghaei, Farhood Alizadegan, Yosra Raziani, Githa Kishore, Massumeh Saadatmand, Suja Ajoy Kumar   +5 more
doaj   +1 more source

Discovery of new organoselenium compounds as antileishmanial agents [PDF]

Bioorganic Chemistry, 2019
We report new organoselenium compounds bearing the sulfonamide moiety as effective inhibitors of the β-isoform of Carbonic Anhydrase from the unicellular parasitic protozoan L. donovani chagasi. All derivatives were evaluated in vitro for their leishmanicidal activities against Leishmania infantum amastigotes along with their cytotoxicities in human ...
Al-Tamimi A. -M. S., Etxebeste-Mitxeltorena M., Sanmartin C., Jimenez-Ruiz A., Syrjanen L., Parkkila S., Selleri S., Carta F., Angeli A., Supuran C. T.   +9 more
openaire   +4 more sources

Leishmaniasis: Plants as a source of antileishmanial agents

Journal of Experimental Biology and Agricultural Sciences, 2022
Leishmania infection causes a group of tropical diseases and has remained neglected for decades. It spreads by sandfly vector and is one of the most fatal protozoan diseases after malaria. Leishmaniases are a group of diseases caused by the infection of different Leishmania species and display clinically different forms like “Visceral leishmaniasis ...
Manoj Kumar Singh, Arpita Das, Rudra P Saha, Joydeep Paul, Debkumar Nandi   +4 more
openaire   +1 more source

52500 Characterization of a Series of 1,4-diaryl-pyrazolo-pyridinones as Anti-Leishmanial Agents

Journal of Clinical and Translational Science, 2021
IMPACT: The first-line chemotherapies used to treat leishmaniasis are highly toxic intravenous antimonials yet drug resistance has begun to develop, causing the use of oral treatment options with high price tags; there is a strong need for new, safe, and
Hannah N. Corman, Douglas A. Shoue, Bruce J. Melancon, Mary Ann McDowell   +3 more
doaj   +1 more source

Anti-leishmanial and Anti-inflammatory Agents from Endophytes: A Review

Natural Products and Bioprospecting, 2019
Leishmaniases and chronic inflammatory diseases are the cause of millions of deaths in the world each year. The treatment of leishmaniasis is facing serious drawbacks particularly due to the limited number of effective medicines, the resistance, and the ...
Rufin Marie Kouipou Toghueo
doaj   +1 more source

Antileishmanial potential of medicinal plants: A global systematic and meta-analytic review of in vitro studies [PDF]

Journal of HerbMed Pharmacology
Introduction: Leishmaniasis is a major global health challenge with limited treatment options and rising drug resistance. Medicinal plants, traditionally used in many regions, offer a promising source of new antileishmanial agents.
Mohammed-Yassine Takzima, Mohamed Echchakery, Mounia Amane, Mohamed Hafidi, Loubna El fels   +4 more
doaj   +1 more source

Inhibiting Leishmania donovani Sterol Methyltransferase to Identify Lead Compounds Using Molecular Modelling

Pharmaceuticals, 2023
The recent outlook of leishmaniasis as a global public health concern coupled with the reportage of resistance and lack of efficacy of most antileishmanial drugs calls for a concerted effort to find new leads.
Patrick O. Sakyi, Samuel K. Kwofie, Julius K. Tuekpe, Theresa M. Gwira, Emmanuel Broni, Whelton A. Miller, Michael D. Wilson, Richard K. Amewu   +7 more
doaj   +1 more source

Synthesis, Electrochemistry, In Vitro Antiprotozoal Efficacy and Mechanistic Study of Novel ‘Ferrantoin’ and Related Derivatives

Applied Organometallic Chemistry, Volume 40, Issue 7, July 2026.
1,2‐Disubstituted ferrocene analogues bearing hydantoin or rhodanine synthons were synthesised and assessed for antitrypanosomatid activity. An antileishmanial early lead, analogue 23, acting through ROS generation and hence oxidative stress, was uncovered.
Maryna Saayman, Janine Aucamp, Helena D. Janse van Rensburg, Christina Kannigadu, Rotondwa Mphephu, Andrew J. Swarts, Keisuke Suganuma, David D. N'Da   +7 more
wiley   +1 more source

Recent advances in antileishmanial drugs: New leishmaniasis medicine through repurposing approach

Tungs’ Medical Journal
Leishmania is a parasitic protozoan belonging to the family Trypanosomatidae. Leishmaniasis, caused by infection with Leishmania parasites, can manifest in three primary forms: cutaneous, mucocutaneous, and visceral.
Lon-Fye Lye, Chin-Fu Lin, Yen-Chuan Ou, Chih-Ming Chen   +3 more
doaj   +1 more source