Results 11 to 20 of about 4,370 (170)

Thymol and eugenol derivatives as potential antileishmanial agents. [PDF]

Bioorg Med Chem, 2014
In Northeastern Brazil visceral leishmaniasis is endemic with lethal cases among humans and dogs. Treatment is toxic and 5-10% of humans die despite treatment. The aim of this work was to survey natural active compounds to find new molecules with high activity and low toxicity against Leishmania infantum chagasi.
de Morais SM, Vila-Nova NS, Bevilaqua CM, Rondon FC, Lobo CH, de Alencar Araripe Noronha Moura A, Sales AD, Rodrigues AP, de Figuereido JR, Campello CC, Wilson ME, de Andrade HF.   +11 more
europepmc   +4 more sources

N-cinnamoylated aminoquinolines as promising antileishmanial agents. [PDF]

Antimicrob Agents Chemother, 2013
ABSTRACT A series of cinnamic acid conjugates of primaquine and chloroquine were evaluated for their in vitro antileishmanial activities. Although primaquine derivatives had modest activity, chloroquine conjugates exhibited potent activity against both promastigotes (50% inhibitory concentration [IC
Vale-Costa S, Costa-Gouveia J, Pérez B, Silva T, Teixeira C, Gomes P, Gomes MS.   +6 more
europepmc   +6 more sources

Sesamol Induces Apoptosis-Like Cell Death in Leishmania donovani

Frontiers in Cellular and Infection Microbiology, 2021
BackgroundVisceral leishmaniasis (VL), caused by the protozoan parasite Leishmania donovani (L. donovani), is the most severe form of leishmaniasis. It is largely responsible for significant morbidity and mortality in tropical and subtropical countries ...
Rahat Ali, Shams Tabrez, Sajjadul Kadir Akand, Fazlur Rahman, Atahar Husein, Mohd Arish, Ali S. Alqahtani, Mohammad Z. Ahmed, Mohammad Husain, Abdur Rub   +9 more
doaj   +1 more source

Synthesis, antimalarial, antileishmanial evaluation, and molecular docking study of some 3-aryl-2-styryl substituted-4(3H)-quinazolinone derivatives

BMC Chemistry, 2022
Quinazolinones are a diverse group of nitrogen-containing heterocyclic compounds with promising antimalarial and antileishmanial activities. Herein, some 3-aryl-2-styryl substituted-4(3H)-quinazolinones were synthesized via cyclization, condensation, and
Girma Worku Seifu, Yihenew Simegniew Birhan, Botros Youssef Beshay, Ariaya Hymete, Adnan Ahmed Bekhit   +4 more
doaj   +1 more source

Nanomaterials for diagnosis, treatment, and prevention of human cutaneous leishmaniasis: A review

OpenNano, 2023
Leishmania parasites are the organisms responsible for one of the most important tropical diseases, leishmaniasis. This neglected disease mainly affects populations in developing or underdeveloped countries, causing nearly one million new cases per year.
Daniela Maza Vega, Magalí Di Meglio, Silvia del Valle Alonso, Fernando Alvira, Jorge Montanari   +4 more
doaj   +1 more source

Rational repurposing, synthesis, in vitro and in silico studies of chromone-peptidyl hybrids as potential agents against Leishmania donovani

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
A chromone-peptidyl hybrids series was synthesised and rationally repurposed towards identification of potential antileishmanial hits against visceral leishmaniasis.
Ahmed H. E. Hassan, Waleed A. Bayoumi, Selwan M. El-Sayed, Trong-Nhat Phan, Yeon Ju Kim, Chae Hyeon Lee, Soo Bin Cho, Taegeun Oh, Gyeongpyo Ham, Kazem Mahmoud, Joo Hwan No, Yong Sup Lee   +11 more
doaj   +1 more source

In Vitro and In Silico Approaches for the Antileishmanial Activity Evaluations of Actinomycins Isolated from Novel Streptomyces smyrnaeus Strain UKAQ_23

Antibiotics, 2021
Leishmaniasis, a Neglected Tropical Parasitic Disease (NTPD), is induced by several Leishmania species and is disseminated through sandfly (Lutzomyia longipalpis) bites. The parasite has developed resistance to currently prescribed antileishmanial drugs,
Kamal A. Qureshi, Ibrahim Al Nasr, Waleed S. Koko, Tariq A. Khan, M. Qaiser Fatmi, Mahrukh Imtiaz, Riaz A. Khan, Hamdoon A. Mohammed, Mariusz Jaremko, Abdul-Hamid Emwas, Faizul Azam, Avinash D. Bholay, Gamal O. Elhassan, Dinesh K. Prajapati   +13 more
doaj   +1 more source

9-Anilinoacridines as potential antileishmanial agents [PDF]

Antimicrobial Agents and Chemotherapy, 1993
A number of 1'-substituted 9-anilinoacridines were evaluated for their activities against promastigote and amastigote forms of Leishmania major and for their toxicities to human Jurkat leukemia cells. Several compounds possessing 1'-NH-alkyl substituents produced more than 80% growth inhibition of macrophage-infected L.
Mauël J, Denny W, Gamage S, Ransijn A, Wojcik S, Figgitt D, Ralph R   +6 more
openaire   +3 more sources

Arylthiosemicarbazones as antileishmanial agents

European Journal of Medicinal Chemistry, 2016
Based on a screening process, we targeted substituted thiosemicarbazone as potential antileishmanial agents. Our objective was to identify the key structural elements contributing to the anti-parasite activity that might be used for development of effective drugs.
Manzano, José Ignacio, Cochet, Florent, Boucherle, Benjamin, Gómez-Pérez, Verónica, Boumendjel, Ahcène, Gamarro, Francisco, Peuchmaur, Marine   +6 more
openaire   +8 more sources

Efficacy and safety of pharmacotherapeutic interventions used in visceral leishmaniasis clinical trials: A systematic review and network meta-analysis

Asian Pacific Journal of Tropical Medicine, 2022
Objective: To compare the efficacy and safety outcomes of different antileishmanial agents used in visceral leishmaniasis clinical trials. Methods: A systematic literature search in PubMed/MEDLINE, EMBASE, Cochrane, and Google Scholar was done using ...
Aamir Bashir, Gautam Sahu, Ishfaq Rashid, Pramil Tiwari   +3 more
doaj   +1 more source