Results 41 to 50 of about 4,370 (170)

In vitro and in vivo antileishmanial activity of β-acetyl-digitoxin, a cardenolide of Digitalis lanata potentially useful to treat visceral leishmaniasis

Parasite, 2021
Current treatments of visceral leishmaniasis face limitations due to drug side effects and/or high cost, along with the emergence of parasite resistance. Novel and low-cost antileishmanial agents are therefore required.
Freitas Camila S., Lage Daniela P., Oliveira-da-Silva João A., Costa Rafaella R., Mendonça Débora V.C., Martins Vívian T., Reis Thiago A.R., Antinarelli Luciana M.R., Machado Amanda S., Tavares Grasiele S.V., Ramos Fernanda F., Brito Rory C.F., Ludolf Fernanda, Chávez-Fumagalli Miguel A., Roatt Bruno M., Ramos Gabriela S., Munkert Jennifer, Ottoni Flaviano M., Campana Priscilla R.V., Duarte Mariana C., Gonçalves Denise U., Coimbra Elaine S., Braga Fernão C., Pádua Rodrigo M., Coelho Eduardo A.F.   +24 more
doaj   +1 more source

Structural basis of ligand selectivity in FAD/NAD(P)H‐dependent dehydrogenases: insights from trypanothione reductase and type II NADH dehydrogenase

Protein Science, Volume 35, Issue 7, July 2026.
Abstract FAD/NAD(P)H‐dependent dehydrogenases form a structurally conserved family of redox enzymes that participate in essential metabolic processes across parasites and higher organisms. Among them, trypanothione reductase (TR) is a key component of the redox metabolism of Leishmania species and represents an attractive target for antileishmanial ...
Giulia Chiara Maria Perrone, Serena Spadone, Anna Lucia Francavilla, Sara Morselli, Sabino Todisco, Margherita Ortalli, Jairo Alfonso Mendoza‐Roldan, Valeria Scaglione, Maria Noemi Sgobba, Lorenzo Guerra, Federica Belluti, Stefania Varani, Domenico Otranto, Anna De Grassi, Mariateresa Volpicella, Ciro Leonardo Pierri   +15 more
wiley   +1 more source

Phytochemical Profiling, Antiplatelet Potential, and Cytotoxic Assessment of Thymelaea tartonraira Aerial Part Essential Oil: In Vitro and In Silico Studies

Chemistry &Biodiversity, Volume 23, Issue 6, June 2026.
Essential oil from Thymelaea tartonraira was characterized by GC–MS and evaluated using in vitro and in silico approaches. The oil exhibited notable antiplatelet activity with low cytotoxicity. Molecular docking revealed strong interactions of major compounds with GPVI, COX‐1, and P2Y12, supporting its potential as a natural antiplatelet agent ...
Siwar Soltani, Asma Haffouz, Imed Koubaa, Ali Gargouri, Amira Jerbi, Ikram Ben Amor, Jalel Gargouri, Basma HadjKacem, Noureddine Allouche   +8 more
wiley   +1 more source

Chitosan-Based Nanomaterials as Valuable Sources of Anti-Leishmanial Agents: A Systematic Review

Nanomaterials, 2021
Background: The current chemotherapy agents against various forms of leishmaniasis have some problems and side effects, including high toxicity, high cost, and the emergence of resistant strains. Here, we aimed to review the preclinical studies (in vitro
Hamdan I. AlMohammed, Amal Khudair Khalaf, Aishah E. Albalawi, Abdullah D. Alanazi, Parastoo Baharvand, Ali Moghaddam, Hossein Mahmoudvand   +6 more
doaj   +1 more source

Mo‐Catalyzed Synthesis of N‐Polyheterocycles From Functionalized Nitroarenes and Aldehydes

Asian Journal of Organic Chemistry, Volume 15, Issue 5, May 2026.
Mo(VI)‐catalyzed one‐pot conversion of readily available functionalized nitroarenes and aldehydes yielded fused N‐polyheterocycles by sequential nitro reduction, imine formation, and cyclization. Using pinacol as a benign reductant, this sustainable tandem strategy suppresses side reactions and grants rapid access to diverse pharmacologically relevant ...
Raúl Martínez‐González, Rubén Rubio‐Presa, María R. Pedrosa, Samuel Suárez‐Pantiga, Roberto Sanz   +4 more
wiley   +1 more source

Synthesis, antileishmanial, antimalarial evaluation and molecular docking study of some hydrazine-coupled pyrazole derivatives

BMC Chemistry
Pyrazole-bearing compounds are known for their diverse pharmacological effects including potent antileishmanial and antimalarial activities. Herein, some hydrazine-coupled pyrazoles were successfully synthesized and their structures were verified by ...
Halefom Gebreselasse Berhe, Yihenew Simegniew Birhan, Botros Youssef Beshay, Huda Jawad Habib, Ariaya Hymete, Adnan Ahmed Bekhit   +5 more
doaj   +1 more source

Chemical Profiling and Biological Activity of Copaiba Oil‐Resin Samples and Development of HPLC‐DAD Method for the Analysis of β‐Caryophyllene

Biomedical Chromatography, Volume 40, Issue 5, May 2026.
ABSTRACT The Copaifera species are traditionally used for their anti‐inflammatory, antiseptic and healing properties. The objective of this study was to compare the chromatographic profiles of seven samples of copaiba oil‐resin with respect to chromatographic and physicochemical properties and to evaluate their biological activities.
Gabriel de A. P. Graça, Cláudia G. Silva, Denise de O. Scoaris, Juliana Rodrigues de Vasconcelos, André Santos Alkimim, Vanessa C. F. Mosqueira, Luciana S. Salomon, Pietra Piotto Marcellini, Isabelle Renata Martins da Silva, Janete S. C. Santos, Andreia Fonseca Silva, Carolina P. S. Moreira, Júlio C. D. Lopes, Vera L. de Almeida   +13 more
wiley   +1 more source

4040 Investigation of a Series of 1,4-diaryl-pyrazolo-pyridinones as Anti-Leishmanial Agents

Journal of Clinical and Translational Science, 2020
OBJECTIVES/GOALS: This study was conducted in order to identify novel chemical compounds that exhibit anti-leishmanial activity and to further characterize their efficacy and toxicity in in vitro and in vivo systems in the hopes of future ...
Hannah Noel Corman, Douglas A. Shoue, Bruce J. Melancon, Mary Ann McDowell   +3 more
doaj   +1 more source

Manganese Porphyrin‐Catalyzed One‐Pot Oxidation of Lupeol: Efficient Conversion of Its Terminal Alkene Into Carboxylic Acids

Chemistry &Biodiversity, Volume 23, Issue 5, May 2026.
Manganese porphyrin catalyst enables green PhI(OAc)2 oxidation of lupeol in ethyl acetate, achieving 94% conversion and the formation of eight products, including selective C20 olefin transformations and one‐pot conversion of the isopropenyl group to carboxylic acids, all without the need of C3‐OH protection step.
Leila Renan Oliveira, Pedro Fonseca‐Pinheiro, Lucienir Pains Duarte, Diogo Montes Vidal, Grasiely Faria de Sousa, Dayse Carvalho da Silva Martins   +5 more
wiley   +1 more source

Current application of arylazoles and annulated azoles in the design of new antileishmanial agents

Journal of Mazandaran University of Medical Sciences, 2017
Leishmaniasis is a group of tropical diseases with high worldwide prevalence and difficulty in management. At present, the development of resistance and the increase of co-infected leishmaniasis with AIDS have become a serious public health problem. Thus,
Masoud Keighobadi, Hassan Mirzaei, Mahdi Fakhar, Saeed Emami   +3 more
doaj