Results 21 to 30 of about 4,370 (170)

Antileishmanial Activity of the Antiulcer Agent Omeprazole [PDF]

Antimicrobial Agents and Chemotherapy, 2002
ABSTRACT The benzimidazole compound omeprazole, used widely for the treatment of peptic ulcer disease, inhibits the growth of Leishmania donovani , the causative agent of visceral leishmaniasis. Promastigotes cultured at acidic pH and amastigotes within infected macrophages are reduced 90% or more with 150
Suping, Jiang, Juliana, Meadows, Steven A, Anderson, Antony J, Mukkada   +3 more
openaire   +2 more sources

Biological Activity of Coumarin Derivatives as Anti-Leishmanial Agents. [PDF]

PLoS ONE, 2016
Cutaneous leishmaniasis affects nearly 0.7 to 1.3 million people annually. Treatment of this disease is difficult due to lack of appropriate medication and the growing problem of drug resistance. Natural compounds such as coumarins serve as complementary
Vineetha Mandlik, Sohan Patil, Ramanamurthy Bopanna, Sudipta Basu, Shailza Singh   +4 more
doaj   +1 more source

Design, Rational Repurposing, Synthesis, In Vitro Evaluation, Homology Modeling and In Silico Study of Sulfuretin Analogs as Potential Antileishmanial Hit Compounds

Pharmaceuticals, 2022
Direct growth inhibition of infectious organisms coupled with immunomodulation to counteract the immunosuppressive environment might be a beneficial therapeutic approach.
Ahmed H.E. Hassan, Trong-Nhat Phan, Yeonwoo Choi, Suyeon Moon, Joo Hwan No, Yong Sup Lee   +5 more
doaj   +1 more source

The Potential of 2-Substituted Quinolines as Antileishmanial Drug Candidates

Molecules, 2022
There is a need for new, cost-effective drugs to treat leishmaniasis. A strategy based on traditional medicine practiced in Bolivia led to the discovery of the 2-substituted quinoline series as a source of molecules with antileishmanial activity and low ...
Philippe M. Loiseau, Kaluvu Balaraman, Gillian Barratt, Sébastien Pomel, Rémy Durand, Frédéric Frézard, Bruno Figadère   +6 more
doaj   +1 more source

Synthesis and Evaluation of Novel 2,2-Dimethylthiochromanones as Anti-Leishmanial Agents

Molecules, 2021
Within this work, we describe the design and synthesis of a range of novel thiochromanones based on natural products reported to possess anti-leishmanial action, and their synthetic derivatives.
Seán Coll, Mohammad Alhazmi, Patrícia de Aguiar Amaral, Sandra Bourgeade-Delmas, Anne-Cécile Le Lamer, James W. Barlow   +5 more
doaj   +1 more source

Marine Algae as Source of Novel Antileishmanial Drugs: A Review

Marine Drugs, 2017
Leishmaniasis is a vector-borne neglected tropical disease caused by protozoan parasites of the Leishmania genus and transmitted by the female Phlebotomus and Lutzomyia sand flies. The currently prescribed therapies still rely on pentavalent antimonials,
Lauve Rachel Tchokouaha Yamthe, Regina Appiah-Opong, Patrick Valere Tsouh Fokou, Nole Tsabang, Fabrice Fekam Boyom, Alexander Kwadwo Nyarko, Michael David Wilson   +6 more
doaj   +1 more source

Pyrrolidine-based 3-deoxysphingosylphosphorylcholine analogs as possible candidates against neglected tropical diseases (NTDs): identification of hit compounds towards development of potential treatment of Leishmania donovani

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
A rational-based process was adopted for repurposing pyrrolidine-based 3-deoxysphingosylphosphorylcholine analogs bearing variable acyl chains, different stereochemical configuration and/or positional relationships.
Ahmed H. E. Hassan, Trong-Nhat Phan, Seolmin Yoon, Cheol Jung Lee, Hye Rim Jeon, Seung-Hwan Kim, Joo Hwan No, Yong Sup Lee   +7 more
doaj   +1 more source

Synthesis and Evaluation of Antileishmanial and Cytotoxic Activity of Benzothiopyrane Derivatives

Molecules, 2020
In continuation of our efforts to identify promising antileishmanial agents based on the chroman scaffold, we synthesized several substituted 2H-thiochroman derivatives, including thiochromenes, thichromanones and hydrazones substituted in C-2 or C-3 ...
Cristian Ortiz, Fernando Echeverri, Sara Robledo, Daniela Lanari, Massimo Curini, Wiston Quiñones, Esteban Vargas   +6 more
doaj   +1 more source

Tyrosol and hydroxytyrosol derivatives as antitrypanosomal and antileishmanial agents [PDF]

European Journal of Medicinal Chemistry, 2016
Trypanosomiasis and leishmaniasis keep being a real challenge for health and development of African countries. Existing treatments have considerable side effects and increase resistance of the parasites. We have measured antitrypanosomal and antileishmanial activity of natural phenols, tyrosol (TYR) and hydroxytyrosol (HT) and several of their esters ...
Belmonte Reche, Efres, MARTÍNEZ GARCÍA, MARTA, Peñalver, Pablo, Verónica, Gómez-Pérez, Ricardo, Lucas, Gamarro, Francisco, Pérez-Victoria, José María, Morales, Juan Carlos   +7 more
openaire   +6 more sources

In-Vitro Leishmanicidal Activity and Molecular Docking Simulations of a Flavonoid Isolated from Pistacia integerrima Stew ex Brandis

Journal of Food Quality, 2022
Pistacia integerrima Stew ex Brandis is a valued medicinal plant used for curing various diseases such as diarrhea, fever, liver disorder, pain, asthma, and inflammation. The aim of this study was the isolation of bioactive leishmanicidal agents from the
Hassan A. Hemeg, Abdur Rauf, Umer Rashid, Naveed Muhammad, Yahya S. Al-Awthan, Omar S. Bahattab, Mohammed A. Al-Duais, Syed Uzair Ali Shah, Rohit Sharma   +8 more
doaj   +1 more source