Results 11 to 20 of about 2,982 (119)

Hepatotoxicity induced by horse ATG and reversed by rabbit ATG: a case report

Journal of Medical Case Reports, 2007
Background The use of antilymphocyte agents has improved patient and graft survival in hematopoietic stem cell and solid organ transplantation but has been associated with the development of short-term toxicities as well as long-term complications.
Al-Anazi Khalid A, Aljurf Mahmoud D, Al-Sharif Fahad Z, Al-Omar Hamad M, Alami Ahmed, Farooq Fayyaz   +5 more
doaj   +1 more source

Heart Allograft Tolerance Induced and Maintained by Vascularized Hind-Limb Transplant in Rats

Clinical and Developmental Immunology, 2013
Organ/tissue transplantation has become an effective therapy for end-stage diseases. However, immunosuppression after transplantation may cause severe side effects. Donor-specific transplant tolerance was proposed to solve this problem. In this study, we
Quan Liu, Yong Wang, Atsunori Nakao, Wensheng Zhang, Vijay Gorantla, Xin Xiao Zheng   +5 more
doaj   +1 more source

Successful Single Donor Islet Allotransplantation in the Streptozotocin Diabetes Rat Model

Cell Transplantation, 2002
The objective of this study was to define pretransplant islet culture conditions for optimum tissue engraftment in the rat islet allotransplantation model. Lewis rat islets were cultured in TCM 199/5% fetal calf serum for 1 day at 37°C, followed by 1 day
Henning Jahr, Birte Hußmann, Torsten Eckhardt, Reinhard G. Bretzel   +3 more
doaj   +1 more source

Paroxysmal Nocturnal Hemoglobinuria in Patients with Aplastic Anemia: Challenges, Characteristics, and Analysis of Clinical Experience

Клиническая онкогематология, 2019
Background & Aims. Paroxysmal nocturnal hemoglobinuria (PNH) is a disease caused by an acquired clonal disorder of hematopoietic stem cells with clone cell membrane hypersensitivity to the complement.
Elena Romanovna Shilova, T. V. Glazanova, Zh. V. Chubukina, O. E. Rozanova, M. N. Zenina, A. V. Seltser, V. I. Rugal, V. A. Balashova, V. A. Kobilyanskaya, I. I. Krobinets, V. Yu. Udal’eva, I. I. Zotova, L. V. Stelmashenko, N. A. Romanenko, T. B. Zamotina, I. V. Khorsheva, S. V. Voloshin   +16 more
doaj   +1 more source

Anti T-lymphocyte Globulin (Grafalon®) Use during Rabbit Anti-thymocyte Globulin (Thymoglobulin®) Shortage – A Single-center Experience

Indian Journal of Transplantation
Introduction: During a period of local nonavailability of rabbit anti-thymocyte globulin (rATG) in India, anti-T-lymphocyte globulin (ATLG) was utilized in high-risk renal transplantation.
Shailendra Tiwari, Namrata S Rao, Abhilash Chandra, Majibullah Ansari, Sanjeet Kumar Singh   +4 more
doaj   +1 more source

Regulatory T Cells Maintain Peripheral Tolerance to Islet Allografts Induced by Intrathymic Injection of MHC Class I Allopeptides

Cell Transplantation, 1999
Although transplantation remains the treatment of choice for diabetes mellitus, immunological rejection of allografts continues to be a major problem.
David V. Saborio, Nepal C. Chowdhury, Ming-Xing Jin, Anil Chandraker, Mohamed H. Sayegh, Soji F. Oluwole M.D.   +5 more
doaj   +1 more source

Indigenous antithymocyte globulin-equine to treat aplastic anaemia in adults: a case series from two centres in northeast India

Hematology, Transfusion and Cell Therapy
Background: Immunosuppressive therapy is the standard management of adults with aplastic anaemia. Antithymocyte globulin is used as first-line treatment of patients not eligible for bone marrow transplantation.
Asif Iqbal, Abhijit Phukan, Chandana Sharma   +2 more
doaj   +1 more source

Breast Cancer: Molecular Pathogenesis and Targeted Therapy

MedComm, Volume 6, Issue 10, October 2025.
Dysregulation signaling pathways in various breast cancer subtypes and their targeting using different inhibitors. ABSTRACT Breast cancer (BC) is the most prevalent cancer in women and remains the leading cause of cancer‐related mortality globally.
Md Abdus Samad, Iftikhar Ahmad, Mohammad Rashid Khan, Mohd Suhail, Torki A. Zughaibi, Fahad A. Al‐Abbasi, Khaled A. Alhosaini, Mohd Shahnawaz Khan, Ajoy Kumer, Shams Tabrez   +9 more
wiley   +1 more source

Reapplication of the Type IV Hypersensitivity Quantitative Risk Assessment to Assess Ingredients Used on Canines

Veterinary Medicine and Science, Volume 11, Issue 4, July 2025.
A contact allergen quantitative risk assessment framework has been successfully deployed for humans but not dogs despite the need. This review summarizes evidence that humans and dogs share the Type IV hypersensitivity adverse outcome pathway and concludes that hazard thresholds derived from historic human, mice or Guinea pig studies can be applied to ...
Austin McDermott, Gwendolen Lorch, J. Nash, Petra Kern   +3 more
wiley   +1 more source

Soluble ST2 as a Predictive Biomarker for Acute Graft‐Versus‐Host Disease Post ‐Allogeneic Stem Cell Transplantation

Clinical Transplantation, Volume 39, Issue 3, March 2025.
ABSTRACT Background Acute graft‐versus‐host disease (aGVHD) remains a major complication of allogeneic hematopoietic stem cell transplantation (allo‐HSCT). Identifying reliable biomarkers for early prediction of aGVHD could enable timely interventions and improve patient outcomes. Objective This study aims to assess whether levels of specific cytokines
Ken Huang, Mengxin Yang, Jinfang Huang, Yaxuan Cao, Yuhang Zhou, Guanxiu Pang, Jie Zhao, Jianming Luo   +7 more
wiley   +1 more source