Results 31 to 40 of about 921,945 (165)

Breast Cancer: Molecular Pathogenesis and Targeted Therapy

MedComm, Volume 6, Issue 10, October 2025.
Dysregulation signaling pathways in various breast cancer subtypes and their targeting using different inhibitors. ABSTRACT Breast cancer (BC) is the most prevalent cancer in women and remains the leading cause of cancer‐related mortality globally.
Md Abdus Samad, Iftikhar Ahmad, Mohammad Rashid Khan, Mohd Suhail, Torki A. Zughaibi, Fahad A. Al‐Abbasi, Khaled A. Alhosaini, Mohd Shahnawaz Khan, Ajoy Kumer, Shams Tabrez   +9 more
wiley   +1 more source

Cardiac troponin I but not cardiac troponin T adheres to polysulfone dialyser membranes in an in vitro haemodialysis model: explanation for lower serum cTnI concentrations following dialysis. [PDF]

, 2014
BACKGROUND: Elevated serum cardiac troponin T (cTnT) and I (cTnI) can occur in patients with chronic kidney disease. Differences in cTn concentrations between cTnT and cTnI have been reported but the mechanism of such discrepancy has not been ...
Collinson, PO, Gaze, D.C., David C Gaze, Collinson, P., Gaze, DC, Paul O Collinson   +5 more
core   +1 more source

Reapplication of the Type IV Hypersensitivity Quantitative Risk Assessment to Assess Ingredients Used on Canines

Veterinary Medicine and Science, Volume 11, Issue 4, July 2025.
A contact allergen quantitative risk assessment framework has been successfully deployed for humans but not dogs despite the need. This review summarizes evidence that humans and dogs share the Type IV hypersensitivity adverse outcome pathway and concludes that hazard thresholds derived from historic human, mice or Guinea pig studies can be applied to ...
Austin McDermott, Gwendolen Lorch, J. Nash, Petra Kern   +3 more
wiley   +1 more source

Studies on the Preparation, Purification and In Vitro Activity of Horse Anti-human lymphocyte Serum. [PDF]

, 1971
The present paper contains the method of preparation, purification, and in vitro activity of antilymphocyte serum for the production of standardized, nontoxic material for clinical use. Two horses were immunized with human thymus cells for 5 months and 9
数井, 暉久
core   +1 more source

Soluble ST2 as a Predictive Biomarker for Acute Graft‐Versus‐Host Disease Post ‐Allogeneic Stem Cell Transplantation

Clinical Transplantation, Volume 39, Issue 3, March 2025.
ABSTRACT Background Acute graft‐versus‐host disease (aGVHD) remains a major complication of allogeneic hematopoietic stem cell transplantation (allo‐HSCT). Identifying reliable biomarkers for early prediction of aGVHD could enable timely interventions and improve patient outcomes. Objective This study aims to assess whether levels of specific cytokines
Ken Huang, Mengxin Yang, Jinfang Huang, Yaxuan Cao, Yuhang Zhou, Guanxiu Pang, Jie Zhao, Jianming Luo   +7 more
wiley   +1 more source

Effectiveness and Safety of Reduced Thymoglobulin Dosing in Low‐Risk Kidney Transplant Recipients

Journal of Transplantation, Volume 2025, Issue 1, 2025.
Introduction Thymoglobulin, a lymphocyte‐depleting agent, is widely used for induction immunosuppression in kidney transplantation. Despite guideline support, there is no standardized dosing recommendation, resulting in variability across centers. In April 2022, our institution reduced its institutional practice thymoglobulin dose from 4.5 to 3 mg/kg ...
Eiman Wazwaz, Nina Joiner, Abhay Dhand
wiley   +1 more source

Genetic Determinants of Serum Testosterone Concentrations in Men [PDF]

, 2011
Testosterone concentrations in men are associated with cardiovascular morbidity, osteoporosis, and mortality and are affected by age, smoking, and obesity.
Frank H de Jong, Lyytikäinen LP, Vasan, Ramachandran S, Uitterlinden AG, Wichmann HE, Zhuang WV, Wu, TS, Liu, YM, Rivadeneira Ramirez, F. (Fernando), Lorentzon, M, Murray, A, Harris, Tamara B, Murray Anna, Tajar, A., Kähönen M, Lehtimäki Terho, Stolk, Lisette, Völzke Henry, Mellström, D, Wichmann, H.-E., Reincke, M, Kiel, D.P. (Douglas), Stolk Lisette, Robin Haring, Uitterlinden, Andre G., Bidlingmaier, M, David Karasik, Miljkovic, I, Ziv, E. (Elad), Penninx B, Coviello, A.D., Murabito Joanne M., Pye, SR, EMAS Study Group (), Ljunggren, Osten, Liu, Y, Murabito JM, Uitterlinden, André G, Perry, J.R., Karlsson, Magnus, Wallaschofski, H, Brenda Penninx, Murray, Anna, Ziv E, Lyytikäinen, Leo Pekka, Wallaschofski, H., Marcello Maggio, Perry, John R. B., Lunetta, Kathryn L., Vandenput Liesbeth, Frank H. de Jong, Wichmann, H.E. (Heinz Erich), Wu, Tsung-Sheng, John-Olov Jansson, Uitterlinden, AG, Haring, R., Hofman, A., Tamara B Harris, Koster A, Koster, A, Harris, T.B. (Tamara), Rivadeneira F, Karlsson, Magnus,, Voelker, Uwe, Lunetta, KL, Harris, Tamara, Tamara B. Harris, Murray, A. (Anna), Lehtimäki, Terho (Tay), Heier, Margit, Eriksson, A., Melzer, D, Wu Tsung-Sheng, Miljkovic I, Ohlsson Claes, Rivadeneira, F, Bhasin, S, Murabito, J. (Joanne), Murray A, Petersen, A.K., Nauck, M., Pye, Stephen R., Vandenput, Liesbeth, Petersen AK, Ferrucci, L. (Luigi), Lunetta Kathryn L., Eriksson, A, Huhtaniemi Ilpo T., Eriksson, J, Lehtimaki, T., Penninx, B.W.J.H., Eriksson A, Ulloor Jagadish, Annemarie Koster, Kiel Douglas P., Hofman Albert, Abdelouahid Tajar, Reincke Martin, Eriksson J, Coviello, A.D, Nauck, Matthias, Koster, Annemarie, Kähönen Mika, Völker, U. (Uwe), Kiel, Douglas P., Tajar, A. (Abdelouahid), Ulloor, J, Kähönen, M, Wu, T.-S., Liu Y, Ohlsson, C, Melzer, David, Völzke, H. (Henry), Miljkovic, Iva, Mellström D, Nauck M, Perry JR, Frederick C. W. Wu, Iva Miljkovic, Reincke, M., De Jong, Frank H., Ulloor, J. (Jagadish), Wichmann, H. E., Dan Mellström, Nilsson Maria, Penninx Brenda, Fernando Rivadeneira, Lyytikäinen, L-P, Frederick C W Wu, Eriksson, Anna-Lena,, Miljkovic, I. (Iva), Eriksson Anna, John R B Perry, Hammond, G.L., Jansson JO, Holliday, Kate L., Jansson, JO, Martin Reincke, Ohlsson, C. (Claes), Hammond GL, Pye, Stephen R, MAGGIO, Marcello Giuseppe, Ferrucci, L, Mellstrom, Dan, Murabito, Joanne M., Stolk, L., Nilsson, Maria, Maggio, Marcello, Ramachandran S Vasan, Harris TB, Wu Frederick C. W., Wu, Frederick C. W., Uitterlinden, A.G. (André), Heier, M, Lund University., Kate L. Holliday, Luigi Ferrucci, Douglas P Kiel, de Jong, Frank H, Coviello, AD, Nilsson, M. (Maria), Völzke, H, Haring R., Mika Kähönen, Uitterlinden, A. G., Hofman A, Tajar, Abdelouahid, Wallaschofski, Henri, Raitakari, O, Wu, F.C., Ferrucci Luigi, Vandenput L, Ljunggren, Östen,, Haring, R. (Robin), Emas, SG, EMAS Study Group, Wu, FCW, Teumer, A., Joel Eriksson, Haring Robin, Zhuang, Wei Vivian, Hammond, Geoffrey L., Kiel, Douglas P, Volker, U., Nilsson, Maria,, Stephen R. Pye, Teumer, A, Perry, J.R.B. (John), Vasan, Ramachandran S., Matthias Nauck, Lyytikäinen, Leo-Pekka (Tay), Joanne M Murabito, Koster, A., Wu, F.C.W., Tajar, A, Jansson, John Olov, Petersen, Ann Kristin, Heier M, Heier, M. (Margit), Meitinger T, Mattias Lorentzon, Harris, TB, Tsung-Sheng Wu, Lorentzon, Mattias,, Kiel, D.P., Coviello AD, Bhasin, S., Lunetta, K.L. (Kathryn), Raitakari, Olli, Mellström, Dan,, Bidlingmaier, M. (Martin), Murabito, J.M., Claes Ohlsson, Perry, J.R.B., Wu, T.S., Vandenput, L, Petersen, AK, Huhtaniemi, I.T. (Ilpo), Nilsson M, Pye, S.R., Petersen Ann-Kristin, Hofman, Albert, Jansson, John-Olov,, Yongmei Liu, Teumer Alexander, André G. Uitterlinden, Vandenput, L. (Liesbeth), Meitinger, Thomas, Douglas P. Kiel, Jong, Frank, Volzke, H., Karlsson, M.K. (Magnus), Kathryn L. Lunetta, Voelzke, Henry, Völker Uwe, Wei Vivian Zhuang, Wu FC, Lyytikäinen, L.-P. (Leo-Pekka), Vasan, R.S., Ann-Kristin Petersen, Lehtimäki, T. (Terho), Thomas Meitinger, Kate L Holliday, Karasik, D, Lyytikainen, Leo-Pekka, Holliday KL, Miljkovic Iva, Eriksson, Joel, Lorentzon Mattias, Wallaschofski Henri, Ilpo T. Huhtaniemi, Koster Annemarie, Lorentzon, M., Bidlingmaier, Martin, Stolk, L. (Lisette), Huhtaniemi, Ilpo T, Coviello Andrea D., Osten Ljunggren, Lunetta KL, Huhtaniemi IT, Bidlingmaier, M., Ferrucci, L., Wu, Tsung Sheng, Maggio, M, David Melzer, Vandenput, L., Tajar A, Henry Völzke, Wu TS, Stolk L, Lehtimaki, Terho, Ilpo T Huhtaniemi, Lehtimäki, T, Lorentzon M, H Erich Wichmann, Mellstrom, D., null null, Ziv, E., Vandenput, Liesbeth,, Heier, M., Tajar Abdelouahid, Eriksson, Joel,, Reincke, Martin, Wichmann, H Erich, Penninx, B, Holliday, K.L., Karasik D, Stephen R Pye, Holliday, KL, Teumer, A. (Alexander), Hofman, Bert, Andrea D. Coviello, Völker U, Liu, Y. (YongMei), Lyytikäinen, L.-P., Karlsson, M.K., Mellström Dan, Wallaschofski, H. (Henri), Ferrucci, Luigi, Meitinger, T., Nilsson, M., Penninx, BW, Coviello, Andrea D, Jorma Viikari, Ljunggren Östen, Hammond Geoffrey L., Heier Margit, Ziv Elad, Rivadeneira Fernando, Haring, R, Lunetta, Kathryn L, Ohlsson, C., Meitinger Thomas, Uitterlinden, André, Viikari J, Holliday Kate L., Lorentzon, Mattias, Lorentzon, M. (Mattias), Wu, T-S, Margit Heier, Miljkovic, I., Bhasin S, Petersen, A-K, O'Neill, Terence, Eriksson, J., Rivadeneira, Fernando, Lyytikäinen, LP, Völker, Uwe, Hammond, Geoffrey L, Bidlingmaier Martin, de Jong Frank H., Haring, Robin, Karlsson MK, Murray, A., Raitakari, O., Harris, T.B., Penninx, Brenda, Kähönen, M. (Mika), Nilsson, M, Karasik, D. (David), Olli Raitakari, Kahonen, M., Ohlsson, Claes,, Völzke, Henry, Liu, Y.M., Perry, JR, Wichmann, HE, H. Erich Wichmann, Coviello, Andrea D., Völker, U, Lunetta, K.L., Viikari, J., Jansson, J-O, Viikari, J. (Jorma), Lyytikäinen Leo-Pekka, Vasan Ramachandran S., Perry, John R.B., Kiel, DP, Martin Bidlingmaier, Ziv, Elad, Murabito, JM, Petersen, A.-K., Raitakari Olli, Teumer, Alexander, Harris, Tamara B., Leo-Pekka Lyytikäinen, Elad Ziv, Pye SR, Lyytikainen, L.P., Ramachandran S. Vasan, Emas Study Group,, Nauck Matthias, Nauck, M, Vasan, RS, Karlsson, Magnus K, Henri Wallaschofski, Melzer D, Uitterlinden, André; id_orcid, Kahonen, Mika, Rivadeneira, F., Liu, Yongmei, Holliday, K.L. (Kate), Holliday, Kate L, Viikari, J, Völzke H, Ulloor, J., Raitakari O, Jagadish Ulloor, Maggio, M., Perry, JRB, Jansson, J.O., Joanne M. Murabito, Pye Stephen R., Hofman, A. (Albert), Lehtimäki T, Bhasin, Shalender, Melzer David, Viikari Jorma, de Jong, F.H., Coviello, A.D. (Andrea), Albert Hofman, Perry John R. B., Geoffrey L Hammond, Ulloor J, Huhtaniemi, Ilpo T., Harris Tamara B., Meitinger, T, Uitterlinden André G., André G Uitterlinden, Maggio, M. (Marcello), Melzer, D. (David), Melzer, D., Maria Nilsson, Reincke, M. (Martin), Ljunggren, Ö., Zhuang, WV, Karasik, D., Viikari, Jorma, Karlsson, MK, Zhuang, W.V., Huhtaniemi, IT, Wu, Frederick CW, Liesbeth Vandenput, Anna Eriksson, Huhtaniemi, I.T., Ziv, E, Uitterlinden, A.G., Karasik, David, Liu Yongmei, Teumer A, Eriksson Joel, Wichmann, Heinz-Erich, Alexander Teumer, Geoffrey L. Hammond, Nauck, M. (Matthias), Magnus K Karlsson, Kiel DP, Vasan, R.S. (Ramachandran Srini), Ohlsson C, Anna Murray, Karlsson, Magnus K., Ulloor, Jagadish, Ferrucci L, Hammond, G.L. (Geoffrey), John R. B. Perry, Koster, A. (Annemarie), Ljunggren, O, Karlsson Magnus K., Ljunggren O, Vasan RS, Shalender Bhasin, Kähönen, Mika (Tay), Bhasin Shalender, Jong, F.H. (Frank) de, de Jong FH, Wichmann, H. Erich, Penninx, B., Wallaschofski H, Raitakari, O. (Olli), Hofman, A, Reincke M, Perry, John R B, Perry, John RB, Pye, S.R. (Stephen), Penninx, B.W.J.H. (Brenda), Wu, Frederick C W, Stolk, L, Andrea D Coviello, Magnus K. Karlsson, Bidlingmaier M, Jansson, John-Olov, Wu, FC, Petersen, Ann-Kristin, Zhuang Wei Vivian, Hammond, GL, Bhasin, S. (Shalender), Eriksson, J. (Joel), Meitinger, T. (Thomas), Mellström, D. (Dan), Uwe Völker, Liu, Y., Murabito, Joanne M, Kathryn L Lunetta, de Jong, FH, Wichmann H. Erich, Eriksson, Anna, Ohlsson, Claes, Lisette Stolk, Terho Lehtimäki, Jansson John-Olov, Maggio Marcello, Karasik David   +491 more
core   +4 more sources

Stress Effect of Antilymphocyte Serum [PDF]

BMJ, 1969
Antilymphocyte serum prepared in the rabbit against guinea-pig lymph node cells produces a sustained weight loss when injected into normal guinea-pigs over 14 days, compared with a very transient loss produced by normal rabbit serum. Antilymphocyte serum also produces a much greater increase in plasma cortisol level than normal rabbit serum.
E J, Field, D B, Cook
openaire   +2 more sources

Treatment of newly diagnosed severe aplastic anemia in children: Evidence‐based recommendations

Pediatric Blood &Cancer, Volume 71, Issue 8, August 2024.
Abstract Severe aplastic anemia (SAA) is a rare potentially fatal hematologic disorder. Although overall outcomes with treatment are excellent, there are variations in management approach, including differences in treatment between adult and pediatric patients. Certain aspects of treatment are under active investigation in clinical trials.
Kristin A. Shimano, Jennifer A. Rothman, Steven W. Allen, Paul Castillo, Jill L. O. de Jong, Yigal Dror, Amy E. Geddis, Bonnie W. Lau, Catherine McGuinn, Anupama Narla, Kathleen Overholt, Maria A. Pereda, Anjali Sharathkumar, Ghadir Sasa, Taizo A. Nakano, Kasiani Myers, Nicholas J. Gloude, Larisa Broglie, Jessica Boklan   +18 more
wiley   +1 more source

Serum cholesterol levels in neutropenic patients with fever [PDF]

, 2002
Hypocholesterolemia, which often accompanies infectious diseases has been suggested to serve as a prognostic marker in hospitalized patients. Even though patients with chemotherapyinduced leukopenia are at high risk of infection and mortality, only ...
Walli, Autar K., Holler, Ernst, Hahn, Joachim, Seidel, Dietrich, Fraunberger, Peter   +4 more
core   +1 more source