Results 201 to 210 of about 92,770 (362)

Ligandless Iron‐Catalyzed C(sp3)─H Bond Fluorination

ChemCatChem, Volume 18, Issue 1, 15 January 2026.
This study uses a simple transition metal complex, Fe(OTf)2 (OTf = CF3SO3−) as a catalyst for directing group‐free C(sp3)─H fluorination in the absence of any added ligand. This work includes condition optimization, substrate testing, and discusses a proposed catalytic cycle based on the results of control experiments.
A. Dina Dilinaer, Alexis Mateo, Marcus W. Drover   +2 more
wiley   +1 more source

Congenital Malaria in Non-Endemic Settings: A Literature Review and Update on Diagnosis and Management. [PDF]

J Travel Med
Patterson CA, Nabarro LE, Kumar S, Nolder D, Chiodini PL.   +4 more
europepmc   +1 more source

Catalytic Strategies For the Synthesis of Dehydrozingerone: Structural Features and Emerging Applications—A Critical Review

ChemCatChem, Volume 18, Issue 1, 15 January 2026.
This review emphasizes the main methods for synthesizing dehydrozingerone (DHZ), highlighting the aldol condensation reaction of vanillin with acetone using homogeneous and heterogeneous catalysts. Furthermore, the main pharmacological properties that characterize DHZ are presented, along with current challenges and perspectives in its production ...
Paula Ramirez, José J. Martinez, Gustavo Romanelli, Maria H. Brijaldo, Fabio B. Passos   +4 more
wiley   +1 more source

A Novel Antimalarial Agent that Inhibits Protein Synthesis in Plasmodium falciparum. [PDF]

Angew Chem Int Ed Engl
Bravo P, Diamanti E, Hamed MM, Bizzarri L, Wiedemar N, Passecker A, Brancucci NMB, Albisetti A, Gumpp C, Illarionov B, Fischer M, Witschel M, Schehl T, Hahne H, Mäser P, Rottmann M, Hirsch AKH.   +16 more
europepmc   +1 more source

Synthesis and In Vitro Activity of Hypofuran B and Analogs Against Plasmodium Falciparum and Trypanosoma Cruzi

ChemMedChem, Volume 21, Issue 1, January 2026.
Hypofuran B, drynaran, and a series of analogs are obtined by crossed aldol condensation from furfural dereivatives. Compunds are tested for in vitro activity agaisnt Trypanosoma cruzi and Plasmodium falciparum. Best results are obtained Against P. falciparum, with IC50 values ranging from 5,35 to 10,35 µg mL−1.
Cristiane Aparecida Franco, Jodieh Oliveira Santana Varejão, Isabela Penna Ceravolo, Victória Miranda Machado, Antoniana Ursine Krettli, Daniela de Melo Resende, Silvane Maria Fonseca Murta, Felipe Terra Martins, Eduardo Jorge Pilau, Vinícius Ribeiro Montes, Markus Kohlhoff, Eduardo V. V. Varejão   +11 more
wiley   +1 more source

Assessing the quality of antimalarial drugs in Equatorial Guinea: a follow-up study. [PDF]

BMJ Glob Health
Kaur H, Paris L, Mba Eyono JN, Nguema Avue RM, Phiri WP, Smith JM, Guerra CA, Riloha Rivas M, García GA.   +8 more
europepmc   +1 more source

A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue [PDF]

, 2017
Ebere Sonoiki, Caroline L. Ng, Lee M, Denghui Guo, Yong-Kang Zhang, Yasheen Zhou, M.R. Alley, Vida Ahyong, Laura M. Sanz, María José Lafuente-Monasterio, Chen Dong, Patrick G. Schupp, Jiří Gut, Jenny Legac, Roland A. Cooper, Francisco‐Javier Gamo, Joseph L. DeRisi, Yvonne R. Freund, David A. Fidock, Philip J. Rosenthal   +19 more
openalex   +1 more source

Exploration and Characterization of the Antimalarial Activity of Pyrimidine‐2,4‐Diamines for which Resistance is Mediated by the ABCI3 Transporter

ChemMedChem, Volume 21, Issue 1, January 2026.
Investigation of the structure‐activity relationship on W482 (1) with a pyrimidine‐2,4‐diamine scaffold culminated in analog 51 with enhanced anti‐plasmodial activity. Forward genetics and phenotypic examination revealed the ABCI3 transporter protein as a putative resistance mechanism.
Mahta Mansouri, Madeline G. Dans, Zijun Low, Katie Loi, Kate E. Jarman, Jocelyn S. Penington, Deyun Qiu, Adele M. Lehane, Benigno Crespo, Franciso‐Javier Gamo, Delphine Baud, Stephen Brand, Paul F. Jackson, Alan F. Cowman, Brad E. Sleebs   +14 more
wiley   +1 more source

Novel heterospirocyclic antimalarials with activity against artemisinin- and multidrug-resistant P. falciparum malaria. [PDF]

Int J Parasitol Drugs Drug Resist
Theodoridis L, Giannangelo C, El-Saafin F, Prabhath MR, Macraild CA, Sharma P, Merino D, Creek DJ, Carvalho TG.   +8 more
europepmc   +1 more source

Ex vivo Sensitivity Profile of Plasmodium falciparum Clinical Isolates to a Panel of Antimalarial Drugs in Ghana 13 Years After National Policy Change

, 2021
Michael F. Ofori, Emma Edinam Kploanyi, Benedicta Ayiedu Mensah, Emmanuel K. Dickson, Eric Kyei‐Baafour, Sampson Gyabaa, Mary Tetteh, Kwadwo Koram, Benjamin Abuaku, Anita Ghansah   +9 more
openalex   +2 more sources