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Synthesis of novel SRPK1-targeting hybrid compounds incorporating antimetabolites for cancer therapy. [PDF]
RSC Med ChemLeonidis G +6 more
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Active glomerular inflammation versus chronicity and fibrosis: the role of targeted therapies in IgA nephropathy. [PDF]
Nephrol Dial TransplantRadhakrishnan J, Lafayette RA.
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Current Opinion in Oncology, 1992
Research efforts over the past year further elucidate the determinants of sensitivity and mechanisms of resistance to the antimetabolites fluorouracil, methotrexate, and cytarabine. Progress has been made in clarifying the complex regulation of target enzyme expression for these antimetabolites.
A P, Chen, J L, Grem
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Research efforts over the past year further elucidate the determinants of sensitivity and mechanisms of resistance to the antimetabolites fluorouracil, methotrexate, and cytarabine. Progress has been made in clarifying the complex regulation of target enzyme expression for these antimetabolites.
A P, Chen, J L, Grem
openaire +4 more sources
Antimetabolite Radiosensitizers
Journal of Clinical Oncology, 2007Radiosensitization with antimetabolites has improved clinical outcome for patients with solid malignancies, especially cancers of the GI tract, cervix, and head and neck. Fluorouracil (FU) and hydroxyurea have been widely used clinically during the last four decades, and promising results have been observed more recently with gemcitabine. Although the
Donna S, Shewach, Theodore S, Lawrence
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Cancer chemotherapy and biological response modifiers, 1990
The mechanisms of action of MTX and 5-FU have been further elucidated. Such studies will be important for the design of drug combinations and for the development of novel antifolate and fluoropyrimidine analogs. A greater understanding of MTX and ara-C transport and drug levels required to optimize transport may also aid in these endeavors ...
C J, Allegra +5 more
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The mechanisms of action of MTX and 5-FU have been further elucidated. Such studies will be important for the design of drug combinations and for the development of novel antifolate and fluoropyrimidine analogs. A greater understanding of MTX and ara-C transport and drug levels required to optimize transport may also aid in these endeavors ...
C J, Allegra +5 more
openaire +3 more sources
Baillière's Clinical Haematology, 1991
R L, Capizzi, J C, White, D J, Fernandes
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R L, Capizzi, J C, White, D J, Fernandes
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