Results 21 to 30 of about 15,196 (172)

Cancer Metabolism and Drug Resistance

Metabolites, 2015
Metabolic alterations, driven by genetic and epigenetic factors, have long been known to be associated with the etiology of cancer. Furthermore, accumulating evidence suggest that cancer metabolism is intimately linked to drug resistance, which is ...
Mahbuba Rahman, Mohammad Rubayet Hasan
doaj   +1 more source

Variation of Cost among Anti-cancer Drugs Available in Indian Market [PDF]

Journal of Clinical and Diagnostic Research, 2016
Introduction: Although cancer remains a major health problem all over the world, its treatment is limited by affordability of patients in a developing country like India.
Bhanu Prakash Kolasani, Divyashanthi Chellathambi Malathi, Raghunatha Rao Ponnaluri   +2 more
doaj   +1 more source

New Steroidal Selenides as Proapoptotic Factors

Molecules, 2023
Cytostatic and pro-apoptotic effects of selenium steroid derivatives against HeLa cells were determined. The highest cytostatic activity was shown by derivative 4 (GI50 25.0 µM, almost complete growth inhibition after three days of culture, and over 97 ...
Izabella Jastrzebska, Natalia Wawrusiewicz-Kurylonek, Paweł A. Grześ, Artur Ratkiewicz, Ewa Grabowska, Magdalena Czerniecka, Urszula Czyżewska, Adam Tylicki   +7 more
doaj   +1 more source

Xeloda as first-line therapy of metastatic colorectal cancer-our experience [PDF]

Archive of Oncology, 2002
BACKGROUND: Results of phase III clinical studies comparing efficacy of Xeloda vs. standard 5-FU/FA protocols as first line therapy of metastatic colorectal carcinoma (MCRC), have shown better efficacy of Xeloda, with less toxic adverse effects, apart ...
Kovčin Vladimir, Ješić Rada, Krivokapić Zoran V., Andrić Zoran, Pavlović Aleksandra   +4 more
doaj   +1 more source

Antimicrobial Peptide Induced-Stress Renders Staphylococcus aureus Susceptible to Toxic Nucleoside Analogs

Frontiers in Immunology, 2020
Cationic antimicrobial peptides (AMPs) are active immune effectors of multicellular organisms and are also considered as new antimicrobial drug candidates.
Alexandro Rodríguez-Rojas, Arpita Nath, Baydaa El Shazely, Baydaa El Shazely, Greta Santi, Joshua Jay Kim, Christoph Weise, Benno Kuropka, Jens Rolff   +8 more
doaj   +1 more source

Vascular Acrosyndromes Associated With Prolonged Tumor Response in Advanced Lung Cancer Patients During Treatment With Antimetabolites: A Report of Two Cases

Frontiers in Oncology, 2021
BackgroundPemetrexed and gemcitabine are both antimetabolites drugs approved in advanced non-small cell lung cancer (NSCLC). Their toxicity profile is well known. However, rare vascular side effects can occur such as vascular acrosyndromes and especially
Margaux Geier, Hélène Babey, Lucie Monceau-Baroux, Gilles Quéré, Renaud Descourt, Divi Cornec, Gilles Robinet   +6 more
doaj   +1 more source

Large Scale Screening of Rhizospheric Allelopathic Bacteria and Their Potential for the Biocontrol of Wheat-Associated Weeds

Agronomy, 2020
Conventional weed control practices have generated serious issues related to the environment and human health. Therefore, there is a demand for the development of alternative techniques for sustainable agriculture.
Tasawar Abbas, Zahir Ahmad Zahir, Muhammad Naveed, Sana Abbas, Mona S. Alwahibi, Mohamed Soliman Elshikh, Adnan Mustafa   +6 more
doaj   +1 more source

MODERN METHODS OF CONTROLLING WOUND HEALING AFTER FISTULIZING GLAUCOMA SURGERY. ANTI-INFLAMMATORY DRUGS AND NEW TRENDS

Oftalʹmologiâ, 2017
The  article  describes  modern approaches  for  controlling  wound  healing  after  fistulizing  glaucoma   surgery.  The  review  recounts international experience of steroidal and nonsteroidal anti-inflammatory drug and their efficacy research study ...
S. Yu. Petrov
doaj   +1 more source

Steroidal Antimetabolites Protect Mice against Trypanosoma brucei

Molecules, 2022
Trypanosoma brucei, the causative agent for human African trypanosomiasis, is an emerging ergosterol-dependent parasite that produces chokepoint enzymes, sterol methyltransferases (SMT), not synthesized in their animal hosts that can regulate cell ...
Minu Chaudhuri, Ujjal K. Singha, Boden H. Vanderloop, Anuj Tripathi, W. David Nes   +4 more
doaj   +1 more source

Ultrasound‐Recharged Sub‐Nanometer Palladium Catalysts for on‐Demand and Self‐Terminating Bioorthogonal Prodrug Activation in Cancer Therapy

Advanced Science, EarlyView.
Safe and precise bioorthogonal therapy of tumors was achieved by an ultrasound‐responsive heterostructured nanoreactor with on‐demand catalytic activity. Under piezoelectric catalysis, the system undergoes reversible Pd2+/Pd0 redox cycling, concurrently enabling spatiotemporally controlled prodrug activation and self‐terminating catalytic dose ...
Daqing Xia, Lei Liu, Shuang Jin, Guangxu Fang, Chang Yu, Yunyun Wu, Lunli Xiang, Hongrui Zhu, Zhenqiang Wang, Jixi Zhang   +9 more
wiley   +1 more source