Results 191 to 200 of about 32,473 (237)
Real-world applications of postneoadjuvant stage I of the staging system for oesophageal squamous cell cancer: what is beyond a pathological complete response? [PDF]
Eur J Cardiothorac SurgHuang Y +10 more
europepmc +1 more source
The NUDIX hydrolase NUDT5 influences purine nucleotide metabolism and thiopurine pharmacology. [PDF]
J Clin InvestKager L, Boztug K.
europepmc +1 more source
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Journal of Pharmaceutical and Biomedical Analysis, 2022
In this study, the values of ionization/protonation constants (pKa) of pemetrexed and raltitrexed, which are folic acid antimetabolites, were determined by reversed-phase liquid chromatography (RPLC) and UV-visible spectrophotometric methods at 25 °C ...
Y. D. Daldal, Ebru Çubuk Demi̇ralay
semanticscholar +1 more source
In this study, the values of ionization/protonation constants (pKa) of pemetrexed and raltitrexed, which are folic acid antimetabolites, were determined by reversed-phase liquid chromatography (RPLC) and UV-visible spectrophotometric methods at 25 °C ...
Y. D. Daldal, Ebru Çubuk Demi̇ralay
semanticscholar +1 more source
The efficacy and toxicity of antineoplastic antimetabolites: role of gut microbiota.
Toxicology, 2021The incidence and mortality of cancer are rapidly growing all over the word. Nowadays, antineoplastic antimetabolites still play a key role in the chemotherapy of cancer.
Xinyi Huang +8 more
semanticscholar +1 more source
Current Opinion in Oncology, 1992
Research efforts over the past year further elucidate the determinants of sensitivity and mechanisms of resistance to the antimetabolites fluorouracil, methotrexate, and cytarabine. Progress has been made in clarifying the complex regulation of target enzyme expression for these antimetabolites.
A P, Chen, J L, Grem
openaire +4 more sources
Research efforts over the past year further elucidate the determinants of sensitivity and mechanisms of resistance to the antimetabolites fluorouracil, methotrexate, and cytarabine. Progress has been made in clarifying the complex regulation of target enzyme expression for these antimetabolites.
A P, Chen, J L, Grem
openaire +4 more sources
Antimetabolite Radiosensitizers
Journal of Clinical Oncology, 2007Radiosensitization with antimetabolites has improved clinical outcome for patients with solid malignancies, especially cancers of the GI tract, cervix, and head and neck. Fluorouracil (FU) and hydroxyurea have been widely used clinically during the last four decades, and promising results have been observed more recently with gemcitabine. Although the
Donna S, Shewach, Theodore S, Lawrence
openaire +2 more sources
Cancer chemotherapy and biological response modifiers, 1990
The mechanisms of action of MTX and 5-FU have been further elucidated. Such studies will be important for the design of drug combinations and for the development of novel antifolate and fluoropyrimidine analogs. A greater understanding of MTX and ara-C transport and drug levels required to optimize transport may also aid in these endeavors ...
C J, Allegra +5 more
+7 more sources
The mechanisms of action of MTX and 5-FU have been further elucidated. Such studies will be important for the design of drug combinations and for the development of novel antifolate and fluoropyrimidine analogs. A greater understanding of MTX and ara-C transport and drug levels required to optimize transport may also aid in these endeavors ...
C J, Allegra +5 more
+7 more sources
Bulletin du cancer, 2012
Antimetabolites are cytotoxic agents, which have been developed for more than 50 years. Which cancer patient did not receive or will not receive 5-fluorouracil or methotrexate during the evolution his or her disease? Antimetabolites are defined as interfering with the synthesis of the DNA constituents; they are structural analogues, either of purine ...
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Antimetabolites are cytotoxic agents, which have been developed for more than 50 years. Which cancer patient did not receive or will not receive 5-fluorouracil or methotrexate during the evolution his or her disease? Antimetabolites are defined as interfering with the synthesis of the DNA constituents; they are structural analogues, either of purine ...
openaire +3 more sources
Baillière's Clinical Haematology, 1991
R L, Capizzi, J C, White, D J, Fernandes
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R L, Capizzi, J C, White, D J, Fernandes
openaire +4 more sources