Results 191 to 200 of about 411,170 (267)

Single‐Mitochondrion ATP Profiling Directs Discovery of Targetable OXPHOS Dependency in Cancers

Advanced Science, EarlyView.
MitoATP‐nFCM integrates nano‐flow cytometry with fluorogenic probes (ATP/membrane potential) and antibodies to quantify mitochondrial metabolites and protein expression at single‐organelle resolution, exposing oxidative phosphorylation (OXPHOS)‐driven metabolic rewiring in cancers.
Xu Xiao, Cheng Lu, Hao Chen, Jing Zhou, Yunyun Hu, Haonan Di, Guoqiang Su, Xiaomei Yan   +7 more
wiley   +1 more source

Chitosan from shrimp shell waste as a carrier for frankincense nanoparticles with enhanced antimicrobial activity. [PDF]

Sci Rep
Ahmed HA, Salama ZA, El-Wahab AEA, Aboul-Enein AM, Nassrallah A.   +4 more
europepmc   +1 more source

MicroRNA‐375‐3p Targets Fatty Acid Synthase and Relish to Regulate Energy Allocation During Pupal Metamorphosis and Starvation

Advanced Science, EarlyView.
During pupal metamorphosis and starvation, elevated 20‐hydroxyecdysone (20E) and suppressed insulin trigger Forkhead box O (FOXO) nuclear translocation, enhancing miR‐375‐3p expression. This downregulates fatty acid synthase (FASN) and Relish, promoting lipid breakdown for energy while prioritizing antioxidant responses over immune functions to support
Peng Chen, Meiqi Cheng, Jianhui Wang, Jing Tang, Xiaoqiao Huang, Yusi Li, Huiling Zhou, Ling Zhang, Yi Dong, Chengjun Li, Bin Li   +10 more
wiley   +1 more source

Investigating the Antimicrobial Activity of Anuran Toxins. [PDF]

Microorganisms
Pucca MB, Marques AGAC, Pereira AFM, Melo-Dos-Santos G, Cerni FA, Jacob BCS, Ferreira IG, Piccolo RL, Sartim MA, Monteiro WM, Oliveira IS.   +10 more
europepmc   +1 more source

Mass Spectrometry Imaging‐Assisted Discovery of Gallotannin Biosynthetic Genes in the Root of Paeonia suffruticosa

Advanced Science, EarlyView.
An integrated approach combining mass spectrometry imaging, transcriptomics, and phylogenetic analysis facilitated the efficient identification of genes involved in gallotannin biosynthesis in Paeonia suffruticosa. As a result, a key UGT and several SCPL acyltransferases responsible for biosynthesizing pentagalloylglucose were successfully identified ...
Yushi Liu, Wenna Duan, Weiwei Tang, Yucheng Zhao, Bin Li   +4 more
wiley   +1 more source

Antimicrobial Activity of Acidifying Hyaluronic Acid-Starch Microfiber Dressings Against Clinical Isolates from Chronic Wounds. [PDF]

J Funct Biomater
Stará I, Moťková P, Vydržalová M, Pejchalová M, Burgert L, Hrdina R, Bouška M, Adam M, Královec K, Brožková I.   +9 more
europepmc   +1 more source

Discovery of H2 Receptor Antagonists as Colistin Enhancers by Targeting Acid Stress Response

Advanced Science, EarlyView.
This study identifies YqgB as a key target for restoring colistin susceptibility in mcr‐positive pathogens under acidic conditions by remodeling phospholipid composition and reducing LPS modification. Deep learning‐based screening reveals H2 receptor antagonists as novel colistin adjuvants. Further investigations indicate that ranitidine and famotidine
Jinju Cai, Mengping He, Jianya Luo, Shuang Zhou, Tengyue Zhang, Jianing Li, Zhiqiang Wang, Yuan Liu   +7 more
wiley   +1 more source

Magnetoplasmonic Nanostructures from Magnetite with Noble Metal Surface Modification and Their Antimicrobial Activity. [PDF]

Int J Mol Sci
Ardeleanu H, Ardeleanu MC, Dunca S, Grigoras M, Ababei G, Pricop D, Ursu L, Bulai G, Timpu D, Lupu N, Ciobica A, Racuciu M, Creanga D.   +12 more
europepmc   +1 more source