Results 51 to 60 of about 6,474,405 (299)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Antimicrobial resistance and antimicrobial activity of plant-based antimicrobial peptides against bacteria

Letters in Animal Biology
Antimicrobial peptides (AMPs) are a class of short, usually positively charged, polypeptides which are widely used to overcome the threat of the antimicrobial resistance. The potential of the AMPs is increasing as a new class of antibiotics.
Asif Ali, Silla Ambrose, Dilawar Hussain, Faisal Hafeez, Tayyaba Asghar, Syed Noraiz Arif Shah, Momina Ahsan, Muhammad Shakir, Arsam Ali, Arslan Muhammad Ali Khan, Muhammad Usama Javed   +10 more
doaj   +1 more source

Antimicrobial activity of flavonoids

International Journal of Antimicrobial Agents, 2005
Flavonoids are ubiquitous in photosynthesising cells and are commonly found in fruit, vegetables, nuts, seeds, stems, flowers, tea, wine, propolis and honey. For centuries, preparations containing these compounds as the principal physiologically active constituents have been used to treat human diseases.
Cushnie, T.P.T., Lamb, A.J.
openaire   +2 more sources

Antimicrobial drug use and resistance in Europe [PDF]

, 2008
Our study confronts the use of antimicrobial agents in ambulatory care with the resistance trends of 2 major pathogens, Streptococcus pneumoniae and Escherichia coli, in 21 European countries in 2000–2005 and explores whether the notion that ...
Grundmann, Hajo, Goossens, Herman, Ferech, Matus, Zarb, Peter, Sande-Bruinsma, Nienke van de, Verloo, Didier, Tiemersma, Edine, Monen, Jos, European Antimicrobial Resistance Surveillance System and European Surveillance of Antimicrobial Consumption Project Groups   +8 more
core   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Synthesis, structure, and antimicrobial activity of aminated 5-chloro-6-nitrobenzofurazan with substituted anilines

Учёные записки Казанского университета: Серия Естественные науки, 2017
A simple and efficient procedure for synthesis of nucleophilc aromatic substitution products in benzofurazan cycle on the basis of reactions of substituted anilines with 5-chloro-6-nitrobenzofurazan has been elaborated. The obtained products have a broad
I.V. Galkina, G.L. Takhautdinova, Kh.R. Khayarov, L.M. Yusupova, O.I Gnezdilov, A.V. Ilyasov, V.I. Galkin   +6 more
doaj  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Nanoscale silver: Thin-film structure and antimicrobial functionality [PDF]

, 2012
Since antiquity, silver has been used as a material to reduce spoilage. Over the past decades, there has been an increasing scientific and commercial interest in developing silver surfaces due to the increasing number of drug resistant microorganisms. In
DEAN, ANDREW,KRISTOFFER
core  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Antimicrobial and Efflux Pump Inhibitory Activity of Caffeoylquinic Acids from Artemisia absinthium against Gram-Positive Pathogenic Bacteria [PDF]

, 2010
Background: Traditional antibiotics are increasingly suffering from the emergence of multidrug resistance amongst pathogenic bacteria leading to a range of novel approaches to control microbial infections being investigated as potential alternative ...
Han Haley, Jacques Vervoort, Alexandre M. J. J. Bonvin, George P Tegos, Lewis Kim, Panagiotis L. Kastritis, Vervoort, J., NMR Spectroscopy, Michael R. Hamblin, Kastritis, P., Vervoort Jacques, Exarchou, Vassiliki, Vervoort, Jacques, Bonvin, A.M., Kastritis Panagiotis L., Hamblin, Michael, Tegos, George, Tegos, George P., Lewis, K., Kim Lewis, George P. Tegos, Bonvin, Alexandre M. J. J., Panagiotis L Kastritis, Bonvin Alexandre M. J. J., Sub NMR Spectroscopy, Han, H., Tegos, G.P., Alexandre M J J Bonvin, Fiamegos Yiannis C., Fiamegos, Y.C., Yiannis C Fiamegos, Kastritis, P.L., Hamblin, Michael R., Exarchou Vassiliki, Lewis, Kim, Exarchou, V., Han, Haley, Hamblin Michael R., Tegos George P., Michael R Hamblin, Fiamegos, Yiannis C., Haley Han, Yiannis C. Fiamegos, Kastritis, Panagiotis L., Vassiliki Exarchou, Bonvin, A.M.J.J., Hamblin, M.R., Vervoort, J.J.M.   +47 more
core   +3 more sources