Results 51 to 60 of about 6,832,367 (297)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Anticancer and antimicrobial activity of methoxy amino chalcone derivatives [PDF]

, 2015
A series of methoxy amino chalcone derivatives have been synthesized and evaluated for their anticancer activity against breast cancer cells line T47D and their antimicrobial activity against Escherichia coli ATCC 25923, Staphylococcus aureus ATCC 25922,
Mustofa, .-, Ni’matuzahroh, .-, Jumina, .-, Ni Nyoman Tri Puspaningsih, .-, Hery Suwito, .-   +4 more
core   +2 more sources

Antimicrobial resistance and antimicrobial activity of plant-based antimicrobial peptides against bacteria

Letters in Animal Biology
Antimicrobial peptides (AMPs) are a class of short, usually positively charged, polypeptides which are widely used to overcome the threat of the antimicrobial resistance. The potential of the AMPs is increasing as a new class of antibiotics.
Asif Ali, Silla Ambrose, Dilawar Hussain, Faisal Hafeez, Tayyaba Asghar, Syed Noraiz Arif Shah, Momina Ahsan, Muhammad Shakir, Arsam Ali, Arslan Muhammad Ali Khan, Muhammad Usama Javed   +10 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Eucalyptus oleosa Essential Oils: Chemical Composition and Antimicrobial and Antioxidant Activities of the Oils from Different Plant Parts (Stems, Leaves, Flowers and Fruits) [PDF]

, 2011
Essential oils obtained by hydrodistillation from the different parts (stems, adult leaves, immature flowers and fruits) of Eucalyptus oleosa were screened for their antioxidant and antimicrobial properties and their chemical composition. According to GC-
Abderrabba, Manef, Mathieu, Florence, Ben Marzoug, Hajer Naceur, Bouajila, Jalloul, Manef Abderraba, Mehrez Romdhane, Lebrihi, Ahmed, Hajer Naceur Ben Marzoug, Jalloul Bouajila, Florence Mathieu, Mohamed Larbi Khouja, Romdhane, Mehrez, Khouja, Mohamed Larbi, François Couderc, Couderc, François, Ahmed Lebrihi   +15 more
core   +1 more source

Synthesis, structure, and antimicrobial activity of aminated 5-chloro-6-nitrobenzofurazan with substituted anilines

Учёные записки Казанского университета: Серия Естественные науки, 2017
A simple and efficient procedure for synthesis of nucleophilc aromatic substitution products in benzofurazan cycle on the basis of reactions of substituted anilines with 5-chloro-6-nitrobenzofurazan has been elaborated. The obtained products have a broad
I.V. Galkina, G.L. Takhautdinova, Kh.R. Khayarov, L.M. Yusupova, O.I Gnezdilov, A.V. Ilyasov, V.I. Galkin   +6 more
doaj  

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

High content analysis to determine cytotoxicity of the antimicrobial peptide, melittin and selected structural analogs [PDF]

, 2011
Antimicrobial peptides (AMPs) are naturally occurring entities with potential as pharmaceutical candidates and/or food additives. They are present in many organisms including bacteria, insects, fish and mammals.
O\u27Brien, Peter J., David J. Brayden, Baird, Alan W., Peter J. O’Brien, Marc Devocelle, Devocelle, Marc, Sam Maher, Alan W. Baird, Maher, Sam, Edwin G. Walsh, Walsh, Edwin G., O'Brien, Peter J., Brayden, David James   +12 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source