Results 121 to 130 of about 53,767 (297)

Potent cationic antimicrobial peptides against Mycobacterium tuberculosis in vitro

Journal of Global Antimicrobial Resistance, 2019
Tuberculosis (TB) is known to be one of the 10 causes of global death by infectious agents. The increasing numbers of multiple antibiotic resistance (MDR-TB) and cases of extensive resistance to antibiotics (XDR-TB) have led to the development of new and effective TB therapy.
Sara, Silva, Anabela, Santos-Silva, José Manuel Correia, da Costa, Nuno, Vale   +3 more
openaire   +2 more sources

Loss of VMP1 Impairs Tight Junction Recycling and Aggravates Intestinal Barrier Dysfunction in Inflammatory Bowel Disease

Advanced Science, EarlyView.
This study identifies vacuole membrane protein 1 (VMP1) as a critical regulator of intestinal epithelial barrier homeostasis. VMP1 facilitates the recruitment of CORO1C to late endosomes, supporting Retromer‐mediated recycling of the tight junction protein Occludin.
Jiawei Zhao, Jianjun Zou, Chen Zhou, Yingui Wang, Yiman Liu, Yanqing Zhou, Yuxiang Wang, Xinyu Zhang, Huishu Yang, Hongjie Yin, Dongsheng Bai, Yue Zhao, Na Lu   +12 more
wiley   +1 more source

Isolation and characterisation of host defence peptides ostricacins from ostrich heterophils : a thesis presented in partial fulfilment of the requirements for the degree of Masterate of Technology in Biotechnology at Massey University, Palmerston North, New Zealand [PDF]

, 2006
Articles in Appendix 3 removed due to copyright. Articles available in print copy held in the library.Host defence peptides are ubiquitous components of innate immunity within all living organisms.
Sugiarto, Haryadi
core  

Detergent-like actions of linear amphipathic cationic antimicrobial peptides

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2006
Antimicrobial peptides have raised much interest as pathogens become resistant against conventional antibiotics. We review biophysical studies that have been performed to better understand the interactions of linear amphipathic cationic peptides such as magainins, cecropins, dermaseptin, delta-lysin or melittin.
Bechinger, Burkhard, Lohner, Karl
openaire   +2 more sources

Living Hydrogels: Harnessing Microorganism–Material Synergy for Next‐Generation Therapeutics

Advanced Science, EarlyView.
 . ABSTRACT Microorganism‐based therapies, particularly those utilizing probiotics, have emerged as a powerful biomedical strategy owing to their inherent living functionalities. These living systems can dynamically interact with host environments and self‐regulate their activity, offering superior adaptability, prolonged functionality, and ...
Shuifang Mao, Bingyao Bai, Xingqian Ye, Yiliang Lin   +3 more
wiley   +1 more source

Aggregation‐State Dynamics Drive Double Cooperativity Between Antimicrobial Peptides LL‐37 and HNP1

Angewandte Chemie, EarlyView.
The double cooperative effect between LL‐37 and HNP1 arises from dynamic changes in their aggregation state. These LL‐37/HNP1 assemblies reorganize in a target‐dependent manner, suppressing activity toward mammalian cells while enabling potent antibacterial action.
Yuge Hou, Jing Zhang, Koh Takeuchi, Hideo Higuchi, Motoshi Kaya, Rui Li, Jianlu Zheng, Jiali Chen, Go Watanabe, Kaori Sugihara   +9 more
wiley   +2 more sources

A Chirality‐Converted Bacteriolytic Dodecapeptide Regulates Vibrio‐Induced Polymicrobial Infection and Ameliorates Invasion‐Associated Gut Microbiota Disequilibrium

Advanced Science, EarlyView.
Multidrug‐resistant Vibrio infections are rising rapidly and threaten coastal populations worldwide. This study introduces D‐zp37, a chirality‐engineered antimicrobial peptide with exceptional potency against resistant Vibrio species. D‐zp37 kills planktonic cells, blocks mixed‐species biofilms, disrupts essential bacterial stress responses, and shows ...
Ping Zeng, Qipeng Cheng, Xiaoxu Zhang, Honglan Wang, Jinghan Zhang, Xinyi Ding, Pengfei Zhang, Lanhua Yi, Kwok‐Yin Wong, Kin‐Fai Chan, Sheng Chen, Sharon Shui Yee Leung   +11 more
wiley   +1 more source

Nanomedicine Meets Immunotherapy: Advancing Adoptive Cell Therapy with Nanoparticles in the Treatment of Cancer with Sustainability Perspectives

Advanced Science, EarlyView.
This review surveys nanoparticle‐based strategies to enhance adoptive cell therapy, particularly CAR‐T cell approaches, in solid tumor treatment. It describes how nanoparticles can improve tumor immunogenicity and T‐cell infiltration while reducing toxicity, and how they enable in vivo CAR‐T cell generation.
Erica Frostegård, Tatiana Bobrova, Amalie Leinebø, Thibault Leray, Shayamita Ghosh, Lorena García‐Hevia, Chiara Puccinelli, Lorenzo Riccio, Jacopo Sorani, Davide Bonifazi, Julien Caumartin, Emmanuel Donnadieu, Florence Gazeau, Roland Hischier, Else Marit Inderberg, Mónica L. Fanarraga, Maria Loustau, Bernd Nowack, Sébastien Wälchli, Cécilia Ménard‐Moyon   +19 more
wiley   +1 more source

Bottom‐Up Coacervate‐Based Artificial Cells: Integrating Cellular Hallmarks into Complex Life‐Like Systems

Angewandte Chemie, EarlyView.
Current interest in artificial cell research underscores its potential to deepen our understanding of life's fundamental processes. This review highlights advances in bottom‐up coacervate‐based artificial cell engineering via combined integration of cellular hallmarks.
Arjan Hazegh Nikroo, Angshuman Das, Madelief A. M. Verwiel, Jan C. M. van Hest   +3 more
wiley   +2 more sources

Evaluation of the synergistic potential and mechanisms of action for de novo designed cationic antimicrobial peptides

Heliyon
Antimicrobial peptides (AMPs) have emerged as promising candidates in combating antimicrobial resistance – a growing issue in healthcare. However, to develop AMPs into effective therapeutics, a thorough analysis and extensive investigations are essential.
Margarita Karapetian, Evgenia Alimbarashvili, Boris Vishnepolsky, Andrei Gabrielian, Alex Rosenthal, Darrell E. Hurt, Michael Tartakovsky, Mariam Mchedlishvili, Davit Arsenadze, Malak Pirtskhalava, Giorgi Zaalishvili   +10 more
doaj   +1 more source