Results 221 to 230 of about 28,103 (254)
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Converting Teixobactin into a Cationic Antimicrobial Peptide (AMP)
Journal of Medicinal Chemistry, 2017Teixobactin is a head to side chain cyclodepsipeptide that contains two positive charges. One is found in the cycle, as a result of the presence of the guanidino-unusual amino acid L-allo-End, while the other is at the N-terminal. Here we introduce 26 new Teixobactin analogues with an increasing number of positive charges.
Shimaa A. H. Abdel Monaim +4 more
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Phage-Encoded Cationic Antimicrobial Peptide Required for Lysis
Journal of Bacteriology, 2022We provide evidence that phiKT produces an antimicrobial peptide for outer membrane disruption during lysis. This protein, designated a disruptin, is a new paradigm for phage lysis and has no similarities to other known lysis genes.
Ashley Holt +11 more
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Cationic Antimicrobial Peptides—The Defensins
2006The term defensin relates different families of host defense peptides (HDPs) in vertebrates, invertebrates, plants, and molds that display structural similarities based on a cystine stabilized antiparallel b-sheet core, with an N-terminal a-helical stretch in many members.
ANTCHEVA, Nikolinka +2 more
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Antiendotoxin activity of cationic peptide antimicrobial agents
Infection and Immunity, 1996The endotoxin from gram-negative bacteria consists of a molecule lipopolysaccharide (LPS) which can be shed by bacteria during antimicrobial therapy. A resulting syndrome, endotoxic shock, is a leading cause of death in the developed world. Thus, there is great interest in the development of antimicrobial agents which can reverse rather than promote ...
M, Gough, R E, Hancock, N M, Kelly
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Novel Therapies Based on Cationic Antimicrobial Peptides
Current Pharmaceutical Biotechnology, 2006Cationic antimicrobial peptides serve as critical defense molecules protecting the host from invading bacteria, viruses and fungi. These antimicrobial peptides are widely distributed in nature and in vertebrates they have been localized to numerous tissues and cells.
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Russian Journal of Bioorganic Chemistry, 2018
Comparative antimicrobial properties of three artificial cationic synthetic antimicrobial peptides (SAMP): (RAhaR)4AhaβA (where R is Arg, Aha is 6-aminohexanoic acid, βA is beta-alanine), (KFF)3K and R9F2 with various amphiphilic properties have been studied relative to pathogenic strains of microorganisms: Gram-negative bacteria Pseudomonas aeruginosa,
N. V. Amirkhanov +2 more
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Comparative antimicrobial properties of three artificial cationic synthetic antimicrobial peptides (SAMP): (RAhaR)4AhaβA (where R is Arg, Aha is 6-aminohexanoic acid, βA is beta-alanine), (KFF)3K and R9F2 with various amphiphilic properties have been studied relative to pathogenic strains of microorganisms: Gram-negative bacteria Pseudomonas aeruginosa,
N. V. Amirkhanov +2 more
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Characterization and performance of short cationic antimicrobial peptide isomers
Peptide Science, 2013ABSTRACTCationic antimicrobial peptides (CAMPs) represent an ancient defense mechanism against invading bacteria, with peptides such as the cathelicidins being essential elements of vertebrate innate immunity. CAMPs are typically associated with broad‐spectrum antimicrobial potency and limited bacterial resistance.
Melanie, Juba +4 more
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Cationic peptides: effectors in innate immunity and novel antimicrobials
The Lancet Infectious Diseases, 2001Cationic antimicrobial peptides are produced by all organisms, from plants and insects to human beings, as a major part of their immediately effective, non-specific defences against infections. With the increasing development of antibiotic resistance among key bacterial pathogens, there is an urgent need to discover novel classes of antibiotics ...
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Cationic Amphiphilic Peptides: Synthetic Antimicrobial Agents Inspired by Nature
ChemMedChem, 2020Rajen Kundu
exaly