Results 141 to 150 of about 108,703 (323)

Predicting antimicrobial drug consumption using web search data [PDF]

, 2018
Consumption of antimicrobial drugs, such as antibiotics, is linked with antimicrobial resistance. Surveillance of antimicrobial drug consumption is therefore an important element in dealing with antimicrobial resistance.
Mølbak, K, Hansen, Niels Dalum, Kåre Mølbak, Lioma, C, Mølbak, Kåre, Niels Dalum Hansen, Cox, IJ, Lioma, Christina, Ingemar J. Cox, Hansen, ND, Cox, Ingemar Johansson, Christina Lioma   +11 more
core   +1 more source

Multi‐Enzyme Mimetic Molybdenum Nitride Nanozymes Reshape Subgingival Microenvironment for Synergistic Periodontitis Therapy via ROS Regulation and Microbiome Remodeling

Advanced Science, EarlyView.
ABSTRACT Periodontitis, a chronic inflammatory disease initiated and sustained by plaque microorganisms and host immune response, remains an intractable oral disease and a leading cause of tooth loss worldwide. Traditional mechanical debridement and adjunctive antibiotic or antiseptic therapy often shows limited efficacy due to the complex anatomical ...
Weiyu Zhang, Zhongwei Yang, Yunfan Zhang, Longwei Wang, Xiaoyu Zhang, Jiahui Mao, Yizhi Dai, Yifan Yuan, Mingge Wang, Xin Yang, Xin Yu, Jing Liu, Chunying Chen   +12 more
wiley   +1 more source

Diversity of Pharmaceuticals Enhances Antibiotic Resistance in the Invertebrate Gut via Biofilm‐Mediated Mechanisms

Advanced Science, EarlyView.
Pharmaceutical diversity acts as an independent driver of antibiotic resistance in soil invertebrates. While bulk soil remains unaffected, the collembolan gut microbiome exhibits significant resistance gene enrichment under complex chemical exposure and diurnal warming.
Yi‐Fei Wang, Ya‐Ning Wang, Da Lin, Jia‐Yang Xu, Feng‐Yuan Qi, Hui‐Ling Cui, Hui‐Jie Lu, Min Qiao, Edward Topp, Dong Zhu, Matthias C. Rillig, Yong‐Guan Zhu   +11 more
wiley   +1 more source

Decline in the Incidence of Healthcare-Associated Methicillin-Resistant Staphylococcus Aureus (Ha-Mrsa) Correlates with Deceased Antimicrobial Consumption at a Tertiary Care Hospital in Taiwan, 2001-2009

, 2011
The present study investigated the long-term impact of antibiotic use policy on the rates of consumption (expressed as daily-defined doses/1000 patient-days) of various parenteral antibiotics and on the prevalence of methicillin- resistant Staphylococcus
李原地;曹世明;李孟智;薛博仁, LEE, YUAN-TI;TSAUR, SHYH-MING;LEE, MENG-CHIH;HSUEH, PO-REN   +1 more
core  

Icariin Enhances the Enzymatic Activity of N‐acetylgalactosaminidase to Augment Akkermansia Abundance in Gut Microbiota for Improved PD‐1 Blockade Efficacy in Tumor Suppression

Advanced Science, EarlyView.
Icariin promoted the growth of Akk by enhancing the activity of N‐acetylgalactosaminidase (Amuc_0920), which enhanced mucin utilization and provided a favorable nutrient environment for bacterial growth. This icariin‐mediated enrichment of Akk further reshaped the tumor microenvironment and promoted CD8+ T cell infiltration, ultimately synergizing with
Shuangying Qiao, Liu Yang, Haibang Hao, Qiuxia Ding, Feng Ding, Zheng Chen, Jinfang Zhang, Yun He, Meng Li, Jun Xu, Chao Wang, Aiping Lu, Fangfei Li   +12 more
wiley   +1 more source

β‐Elemene Rescues Radiation‐Induced Enteritis by Orchestrating a Host‐Microbiome Circuit That Fuels Epigenetic DNA Repair

Advanced Science, EarlyView.
This study elucidates that β‐elemene promotes cellular uptake of L. gasseri‐derived lactate by enhancing the membrane translocation of MCT1 in a CD147‐dependent manner. Intracellular lactate, through the lactylation of RBBP4 at the K26 site, recruits EP300 to the promoter regions of downstream genes (POLD1/POLD3), catalyzing H3K27ac modification.
Jiancheng He, Jiapeng Bao, Shukang Deng, Weijie Zang, Haoming Yan, Zihao Zhao, Guangze Zhang, Ruiqing Liu, Junjie Chen, Yilin Hu, Wanjiang Xue   +10 more
wiley   +1 more source

Stress History Establishes a Transient Tolerant State That Shapes Antibiotic Survival Upon Resuscitation

Advanced Science, EarlyView.
High‐throughput single‐cell analysis of resuscitating bacteria reveals a starvation‐history‐dependent transiently tolerant subpopulation that survives β$\beta$‐lactam exposure by temporarily reducing growth. Distinct from classical persisters, these actively growing yet dynamically modulated cells dominate survival across clinically relevant antibiotic
Kieran Abbott, Georgeos Hardo, Ruizhe Li, Jack Bradley, Ashraf Zarkan, Somenath Bakshi   +5 more
wiley   +1 more source

The impact of vaccination on the consumption of antimicrobials in pigs

, 2015
Antimicrobial agents are being used in modern swine production worldwide, generating concern with regards to the development of antimicrobial resistance. Identifying efficient alternatives has therefore become a subject of interest. The aim of this study was to explore the impact of vaccination as an alternative to antimicrobial consumption in pig ...
openaire   +2 more sources

Relationships between Antimicrobial Use and Antimicrobial Resistance in Gram-Negative Bacteria Causing Nosocomial Infections from 1991–2003 at a University Hospital in Taiwan

, 2009
國內婦女接受子宮切除的人數愈來愈多，而子宮切除後婦女的性生活適應，會影響到其自我認同與人際關係，是需要被重視的議題。本研究目的即在於了解子宮切除婦女性生活的一般經驗，並找出影響術後性生活適應的因素，並進一步以女性主義觀點檢視之。84位良性診斷子宮切除的婦女，在術後3-9個月後接受訪視，其中65位已婚且手術前仍有性生活。結果發現術後有九成的婦女已恢復性生活，其中7.8% 的人有點不滿意。比較手術前後對性生活滿意度的改變情形，有3.9% 變好，13.7%變差，82.4%不變。19.7 ...
薛博仁;陳文慧;陸坤泰, HSUEH, PO-REN;CHEN, WEN-HWEI;LUH, KWEN- TAY   +1 more
core  

A Chirality‐Converted Bacteriolytic Dodecapeptide Regulates Vibrio‐Induced Polymicrobial Infection and Ameliorates Invasion‐Associated Gut Microbiota Disequilibrium

Advanced Science, EarlyView.
Multidrug‐resistant Vibrio infections are rising rapidly and threaten coastal populations worldwide. This study introduces D‐zp37, a chirality‐engineered antimicrobial peptide with exceptional potency against resistant Vibrio species. D‐zp37 kills planktonic cells, blocks mixed‐species biofilms, disrupts essential bacterial stress responses, and shows ...
Ping Zeng, Qipeng Cheng, Xiaoxu Zhang, Honglan Wang, Jinghan Zhang, Xinyi Ding, Pengfei Zhang, Lanhua Yi, Kwok‐Yin Wong, Kin‐Fai Chan, Sheng Chen, Sharon Shui Yee Leung   +11 more
wiley   +1 more source