Results 181 to 190 of about 216,614 (305)

A NeuroD1 AAV‐Based Gene Therapy for Functional Brain Repair in Alzheimer's Disease‐Like Non‐Human Primate Model

Advanced Science, EarlyView.
This study tests NeuroD1 AAV‐based gene therapy in a non‐human primate Alzheimer's disease model. The therapy prevents neuronal damage, inhibits hippocampal atrophy, and reduces neuroinflammation. It also repairs vascular and blood‐brain barrier damage, restores cerebrospinal fluid biomarkers, enhances hippocampal glucose metabolism, and improves ...
Zhouquan Jiang, Yongpeng Qin, Bin Luo, Fan Bai, Jiangyue Liu, Long Ma, Shu He, Rongjie Chen, Yuchen Wang, Shanggong Liu, Ying Sun, Yi Chen, Shuo Zhang, Jiaqi Liang, Feng Liao, Huiyi Wei, Junjie Wei, Lu Wang, Hao Xu, Zheng Wu, Gong Chen, Wenliang Lei   +21 more
wiley   +1 more source

Collecting Multi-country Retrospective Antimicrobial Consumption and Use Data: Challenges and Experience. [PDF]

Clin Infect Dis, 2023
Prifti K, Chi KK, Eraly E, Joh HS, Sujan MJ, Poudyal N, Marks F, Holm M.   +7 more
europepmc   +1 more source

Farm-economic analysis of reducing antimicrobial use whilst adopting good management strategies on farrow-to-finish pig farms [PDF]

, 2015
Dewulf, Jeroen, Hogeveen, Henk, Lauwers, Ludwig, Postma, Merel, Rojo Gimeno, Cristina, Wauters, Erwin   +5 more
core   +1 more source

Macrophage Extracellular Traps in Immunity and Cancer

Advanced Science, EarlyView.
As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li, Eugenie Nepovimova, Adam Grundel, Lukas Peter, Qinghua Wu, Kamil Kuca   +5 more
wiley   +1 more source

Antimicrobial Consumption and Utilisation in Zambia: Results from the Analysis of National Data for the Human and Animal Health Sectors. [PDF]

Antibiotics (Basel)
Mudenda S, Chizimu JY, Daka V, Kasanga M, Mufwambi W, Mwangilwa K, Hangoma J, Gardner P, Chileshe C, Mudenda NB, Sinyawa T, Siame A, Hadunka M, Simwinji FM, Kaunda K, Chibi M, Muhimba Z, Jere E, Siyanga M, Lisulo P, Masaninga F, Mukale S, Bambala A, Shawa M, Chileshe C, Chibwe B, Mukuma M, Phiri BSJ, Mainda G, Suzuki Y, Goma F, Muma JB, Chilengi R.   +32 more
europepmc   +1 more source

An Implantable Scaffold Sequentially Releasing STING Agonist and B7‐H3 Antibody for Bone Metastasis Immunotherapy

Advanced Science, EarlyView.
We developed an implantable dual‐drug depot using GelMA for bone metastasis treatment, co‐delivering MSA‐2 and αB7‐H3‐loaded CaCO3 microparticles. Sustained release from GelMA scaffold enables MSA‐2 to activate STING signaling and enhance T‐cell infiltration and activation, while sequentially released αB7‐H3 blocks MSA‐2‐induced B7‐H3 upregulation ...
Qijun Lin, Hong Xiao, Shuai Fan, Kaimin Cai, Yanteng Xu, Xinwen Wang, Guanhong Chen, Chuandong Lang, Xinsheng Peng, Mingqiang Li, Yuhu Dai   +10 more
wiley   +1 more source

Impact of clinical pharmacist-led antimicrobial stewardship on antibiotic appropriateness, clinical outcomes, and antimicrobial consumption in hospital-acquired and ventilator-associated pneumonia: a randomized controlled trial. [PDF]

Front Public Health
Alsubaie N, Ilyas M, Shah ZA, Habib I, Binsaleh AY, Alrossies AS.   +5 more
europepmc   +1 more source

Leveraging Macrophage Metabolic Reprogramming for Enhanced Anti‐Tumor Immunity

Advanced Science, EarlyView.
Tumor‐associated macrophages (TAMs) are key regulators of the tumor microenvironment (TME), with their metabolic states playing a critical role in tumor progression or regression. This review summarizes current understanding of TAM metabolic plasticity alongside cutting‐edge bioengineering innovations, outlining a roadmap for transforming the ...
Zhiyun Liu, Lingyao Zeng, Xulin Gan, Yilin Zhou, Han Shen, Dan Wu, Xin Shou, Minmin Jiang, Liyun Shi   +8 more
wiley   +1 more source

Relation between Injectable Antimicrobial Consumption and Antimicrobial Susceptibility of Pseudomonas aeruginosa

Japanese Journal of Environmental Infections, 2012
Hajime NAKAI, Kazunari NAKAMURA, Katsuhiro SEKINO, Koji ITO, Takuji WATANABE, Yasunori TERUNUMA, Kasumi KUDO   +6 more
openaire   +2 more sources

Plant Genetic Engineering: Technological Pathways, Application Scenarios, and Future Directions

Advanced Science, EarlyView.
This review maps the fast‐evolving landscape of plant genetic engineering, linking enabling platforms with trait‐focused applications in architecture optimization, stress resilience, yield improvement, and quality enhancement. It highlights how genome editing, transgenic strategies, and emerging multi‐gene approaches reshape breeding pipelines, while ...
Peilin Wang, Wenzhi Wang, Dongjiao Wang, Qibin Wu, Youxiong Que   +4 more
wiley   +1 more source