Results 191 to 200 of about 108,703 (323)

Outcomes of Implementing a Multidimensional Antimicrobial Stewardship Program in a Medical Ward in a Third-Level University Hospital in Northern Italy

Background/Objectives: Antimicrobial stewardship programs (ASPs) optimize antimicrobial use, improving outcomes and reducing resistance. This study assessed the impact of a ward-specific ASP.
Ignazio Castagliuolo, Paola Stano, Michele Tessarin, Paolo Simioni, Elisabetta Mariavittoria Giunco, Sara Lo Menzo, Gianmaria Barbato, Fabio Dalla Valle, Vincenzo Scaglione, Tiziano Martello, Francesca Venturini, Annamaria Cattelan, Maria Mazzitelli, Cristina Contessa, Daniele Donà, Margherita Boschetto, Daniele Mengato, Giacomo Berti   +17 more
core   +1 more source

NET‐DNA Activates the ANXA2/TMEM215/BiP Axis to Promote Mitophagy‐Mediated Anoikis Resistance in Endometriosis

Advanced Science, EarlyView.
NET‐DNA is enriched during early endometriotic lesion establishment and drives anoikis resistance by promoting an ANXA2–TMEM215–BiP axis. This pathway strengthens ER–mitochondria contacts, enhances PINK1/Parkin‐associated mitophagy, preserves mitochondrial homeostasis, and supports ectopic stromal cell survival, thereby facilitating lesion persistence ...
Honglin Wang, Yanling Gou, Huiyan Zhang, Hongli Wang, Beidi Wang, Jinming Liu, Yingying Cao, Ruru Bai, Yuxin Zhao, Xu Han, Chao Feng, Xin Huang, Zongfeng Zhang   +12 more
wiley   +1 more source

Evaluating the effects of antimicrobial stewardship program on antimicrobial consumption and resistance patterns: a quasi-experimental study. [PDF]

BMC Infect Dis
Morsi N, Mosaad E, Ahmed O.
europepmc   +1 more source

Five-Year Evaluation of the PROA-NEN Pediatric Antimicrobial Stewardship Program in a Spanish Tertiary Hospital

Introduction: Actions to reduce and optimize antimicrobial use are crucial in the management of infectious diseases to counteract the emergence of short- and long-term resistance.
Nieves Larrosa Escartin, Aurora Fernández-Polo, Marie Antoinette Frick, Susana Melendo-Perez, Natalia Mendoza-Palomar, on behalf of the PROA-NEN Working Group on behalf of the PROA-NEN Working Group, Pere Soler-Palacin   +6 more
core   +1 more source

Biomimetic Bone Marrow Monocyte Membrane‐Fused Extracellular Vesicles for Targeted Therapy of Myocardial Infarction

Advanced Science, EarlyView.
This study develops a biomimetic delivery system (M‐hEV) by fusing monocyte membranes with extracellular vesicles for targeted therapy of damaged cardiac tissue. The system homes to injured myocardium through specific molecular pathways. In a myocardial infarction model, M‐hEV effectively accumulates in the heart, reduces infarct size, alleviates ...
Jiaxin Song, Hao Yang, Qiqi Zhang, Wenqin Zhou, Rui Wang, Yuxing Xie, Emeli Chatterjee, Guoping Li, Jizong Jiang, Qiulian Zhou, Cuimei Zhao   +10 more
wiley   +1 more source

Temporal trends in antimicrobial consumption and an investigation of hospital antimicrobial stewardship activities through structured interviews. [PDF]

Antimicrob Steward Healthc Epidemiol
Honda H, Murakami S, Kosugi T, Ito A, Hata T, Sasaki Y, Hamamoto Y, Wakugawa T, Shiroma M, Nakamura K, Shiohira H, Karasawa K, Tokuda Y.   +12 more
europepmc   +1 more source

Aptamer‐Directed Porous DNA Nanocomposite Hydrogel for Active Pulp Preservation: Immunomodulation, Stem Cell Recruitment and Reparative Dentinogenesis

Advanced Science, EarlyView.
This study presents an injectable DNA‐based porous hydrogel integrating catechol motifs and targeting aptamers for pulpitis management. Upon in situ crosslinking, the scaffold actively recruits endogenous dental pulp stem cells, restores redox homeostasis, and modulates immune responses.
Luhui Cai, Huan Yu, Zihan Ni, Kan Chen, I‐Chen Tsai, Zeyu Bao, Shuo Sun, Weichang Li, Yunhua Chen, Qiong Xu   +9 more
wiley   +1 more source

Antimicrobial Use and Resistance: An Overview in Human and Veterinary Medicine in Colombia

reservedAntimicrobial resistance is an increasing global health issue, particularly in low- and middle-income countries where healthcare infrastructure and regulations may be limited.
EL KADRI FARAJ, SALLY
core  

Eco‐Geography Reverses Dominant AMR Reservoirs in Klebsiella pneumoniae: Integron‐Rich Mobilomes and Cross‐Niche Connectivity

Advanced Science, EarlyView.
Dominant antimicrobial resistance reservoirs in Klebsiella pneumoniae vary across eco‐geographic settings rather than following a universal pattern. Integrated One Health and global genomic analyses show that lineage structure, integron load, and cross‐niche connectivity shape whether AMR burden accumulates primarily in human or nonhuman compartments ...
Hui Lin, Biao Tang, Hao Xu, Jiajie Qian, Feifan Shi, Junhui Zhao, Xiaorui Mao, Xiaohe Hu, Ruishan Liu, Wenhong Liu, Xiawei Jiang, Beiwen Zheng, Guoping Zhao   +12 more
wiley   +1 more source

Antimicrobial Consumption and Resistance Dynamics Across Healthcare Level: Global Evidence and Stewardship Implications. [PDF]

Pathogens
Raut N, Chaudhary AA, Patil H, Shidhaye S, Khobragade R, Umekar M, Ali MAM, Trivedi R.   +7 more
europepmc   +1 more source