Results 41 to 50 of about 4,493,796 (297)

Global network analysis of drug tolerance, mode of action and virulence in methicillin-resistant S. aureus [PDF]

, 2011
Background: Staphylococcus aureus is a major human pathogen and strains resistant to existing treatments continue to emerge. Development of novel treatments is therefore important.
Barton, Geoffrey J, Peter J Coote, Botting, Catherine H., Katherine A Gould, Geoffrey J Barton, Hinds, Jason, Overton, Ian M., Gould, Katherine A., Coote, Peter J, Gould, Katherine A, Shirran, Sally, Botting, CH, Catherine H Botting, Barton, GJ, Coote, Peter J., Gould, KA, Shirley Graham, Botting, Catherine H, Overton, IM, Ian M Overton, Overton, Ian M, Barton, Geoffrey J., Graham, Shirley, Shirran, S, Overton, Ian M; id_orcid, Hinds, J, Sally Shirran, Coote, PJ, Jason Hinds, Barton, Geoffrey J.; id_orcid, Graham, S, Coote, Peter J.; id_orcid, Shirran, Sally; id_orcid   +32 more
core   +1 more source

The alert for emergence of pig-associated MRSA ST 398 in multi-regions China

One Health
Livestock-associated Methicillin-resistant Staphylococcus aureus (LA-MRSA) lineage ST398 presents a notable public health risk through its transmission from pigs to humans.
Mingquan Cui, Hejia Wang, Ningning Han, Wenli Tang, Xiangbin Song   +4 more
doaj   +1 more source

Pharmacokinetics and Pharmacodynamics of Colistin Combined With Isopropoxy Benzene Guanidine Against mcr-1-Positive Salmonella in an Intestinal Infection Model

Frontiers in Microbiology, 2022
Plasmid-borne colistin resistance mediated by mcr-1 is a growing problem, which poses a serious challenge to the clinical application of colistin for Gram-negative bacterial infections.
Lingli Kong, Lingli Kong, Yixing Lu, Yixing Lu, Liuye Yang, Liuye Yang, Wanying Zhang, Wanying Zhang, Beini Zuo, Beini Zuo, Xianfeng Peng, Zonghua Qin, Miao Li, Zhenling Zeng, Zhenling Zeng, Dongping Zeng, Dongping Zeng   +16 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Fifty years of chicken-source Salmonella in China: Evolutionary shifts in epidemiology, antimicrobial resistance, and genomic lineages

Poultry Science
Salmonella, as a profound foodborne zoonotic pathogen, not only causes acute and chronic disorders in poultry but can also be transmitted to humans through the food chain, posing a serious threat to public health security.
Fangqin Liu, Lu Zhang, Qingchun Shen, Shouzhen Xu, Hejia Wang, Chunping Zhang   +5 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Resistance to antimicrobial agents in bifidobacteria [PDF]

, 2005
Includes bibliographical references (leaves 95-106).For bifidobacteria to survive and achieve colonisation, they have to interact with inhibitory host-produced substances such as bile salts.
Price, Claire Emile
core   +1 more source

Common themes in antimicrobial and anticancer drug resistance

Frontiers in Microbiology, 2022
Antimicrobial and anticancer drug resistance represent two of the main global challenges for the public health, requiring immediate practical solutions.
Mariana Carmen Chifiriuc, Mariana Carmen Chifiriuc, Mariana Carmen Chifiriuc, Mariana Carmen Chifiriuc, Roxana Filip, Roxana Filip, Marian Constantin, Gratiela Gradisteanu Pircalabioru, Gratiela Gradisteanu Pircalabioru, Coralia Bleotu, Coralia Bleotu, Liliana Burlibasa, Elena Ionica, Nicolae Corcionivoschi, Nicolae Corcionivoschi, Grigore Mihaescu   +15 more
doaj   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source