Results 41 to 50 of about 252,315 (298)

Limited effect of patient and disease characteristics on compliance with hospital antimicrobial guidelines [PDF]

, 2005
Objective: Physicians frequently deviate from guidelines that promote prudent use of antimicrobials. We explored to what extent patient and disease characteristics were associated with compliance with guideline recommendations for three common infections.
Gans, ROB; id_orcid, Mol, PGM; id_orcid, Wieringa, Jaap E., Denig, P., Laseur, M., Haaijer-Ruskamp, F.M., Mol, Peter G. M.; id_orcid, Mol, PGM, Degener, JE, NannanPanday, P.V., Laseur, M, Denig, P; id_orcid, Wieringa, J.E., Haaijer-Ruskamp, Flora M., Mol, Peter G. M., Denig, P, NannanPanday, PV, Gans, ROB, Degener, John E., Mol, P.G.M., Gans, Rijk O. B., Gans, Rijk O. B.; id_orcid, Gans, R.O.B., Haaijer-Ruskamp, FM, Degener, J.E.   +24 more
core   +1 more source

Can We Prevent Antimicrobial Resistance by Using Antimicrobials Better?

, 2013
Since their development over 60 years ago, antimicrobials have become an integral part of healthcare practice worldwide. Recently, this has been put in jeopardy by the emergence of widespread antimicrobial resistance, which is one of the major problems ...
Germander Soothill, Hu, Y, Yanmin Hu, Soothill, G, Anthony Coates, Coates, A   +5 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Fifty years of chicken-source Salmonella in China: Evolutionary shifts in epidemiology, antimicrobial resistance, and genomic lineages

Poultry Science
Salmonella, as a profound foodborne zoonotic pathogen, not only causes acute and chronic disorders in poultry but can also be transmitted to humans through the food chain, posing a serious threat to public health security.
Fangqin Liu, Lu Zhang, Qingchun Shen, Shouzhen Xu, Hejia Wang, Chunping Zhang   +5 more
doaj   +1 more source

A five-year retrospective study shows increasing rates of antimicrobial drug resistance in Cabo Verde for both Staphylococcus aureus and Escherichia coli

Journal of Global Antimicrobial Resistance, 2020
Objectives: Data on baseline drug resistance important in informing future antimicrobial stewardship programs. So far, no data on the antimicrobial drug resistance of clinical isolates available for the African archipelago of Cabo Verde.Methods: We ...
Tamar Monteiro, Magdalena Wysocka, Elena Tellez, Ofelia Monteiro, Luzia Spencer, Elisa Veiga, Sandra Monteiro, Carine de Pina, Deisy Gonçalves, Sandrine de Pina, Antonio Ludgero-Correia, Joao Moreno, Teresa Conceição, Marta Aires-de-Sousa, Herminia de Lencastre, Laura J Gray, Manish Pareek, David R. Jenkins, Sandra Beleza, Marco R. Oggioni, Isabel Inês Araujo   +20 more
doaj   +1 more source

Global network analysis of drug tolerance, mode of action and virulence in methicillin-resistant S. aureus [PDF]

, 2011
Background: Staphylococcus aureus is a major human pathogen and strains resistant to existing treatments continue to emerge. Development of novel treatments is therefore important.
Barton, Geoffrey J, Peter J Coote, Botting, Catherine H., Katherine A Gould, Geoffrey J Barton, Hinds, Jason, Overton, Ian M., Gould, Katherine A., Coote, Peter J, Gould, Katherine A, Shirran, Sally, Botting, CH, Catherine H Botting, Barton, GJ, Coote, Peter J., Gould, KA, Shirley Graham, Botting, Catherine H, Overton, IM, Ian M Overton, Overton, Ian M, Barton, Geoffrey J., Graham, Shirley, Shirran, S, Overton, Ian M; id_orcid, Hinds, J, Sally Shirran, Coote, PJ, Jason Hinds, Barton, Geoffrey J.; id_orcid, Graham, S   +30 more
core   +1 more source

Antimicrobial Multidrug Resistance: Clinical Implications for Infection Management in Critically Ill Patients.

, 2023
The increasing incidence of antimicrobial resistance (AMR) worldwide represents a serious threat in the management of sepsis. Due to resistance to the most common antimicrobials prescribed, multidrug-resistant (MDR) pathogens have been associated with ...
Gamze Kalın, Chouaikhi, Arthur, Claire Roger, Emine Alp, Roger, Claire, Kalın, GAMZE, Alp, Emine, Arthur Chouaikhi   +7 more
core   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

The burden of bacterial antimicrobial resistance in the WHO African region in 2019: a cross-country systematic analysis

, 2023
Background A critical and persistent challenge to global health and modern health care is the threat of antimicrobial resistance (AMR). Previous studies have reported a disproportionate burden of AMR in low-income and middle-income countries, but there ...
Antimicrobial Resistance Collaborators
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source