Results 51 to 60 of about 4,493,796 (297)

PlyNJ3: a three-domain endolysin with broad-spectrum anti-streptococcal activity and synergistic efficacy against multidrug-resistant Streptococcus suis

BMC Veterinary Research
Background The global spread of multidrug-resistant (MDR) bacteria prompts the exploration of innovative antimicrobial strategies. Phage lysins—peptidoglycan hydrolases known for species-specific activity and low resistance potential—offer promising ...
Jiaqi Zhao, Jingju Wang, Peizhao Han, Cai Yin, Shushu Gu, Hui Ji, Xiaoming Wang, Liping Wang, Jinhu Huang   +8 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Antimicrobial Multidrug Resistance: Clinical Implications for Infection Management in Critically Ill Patients.

, 2023
The increasing incidence of antimicrobial resistance (AMR) worldwide represents a serious threat in the management of sepsis. Due to resistance to the most common antimicrobials prescribed, multidrug-resistant (MDR) pathogens have been associated with ...
Gamze Kalın, Chouaikhi, Arthur, Claire Roger, Emine Alp, Roger, Claire, Kalın, GAMZE, Alp, Emine, Arthur Chouaikhi   +7 more
core   +1 more source

A five-year retrospective study shows increasing rates of antimicrobial drug resistance in Cabo Verde for both Staphylococcus aureus and Escherichia coli

Journal of Global Antimicrobial Resistance, 2020
Objectives: Data on baseline drug resistance important in informing future antimicrobial stewardship programs. So far, no data on the antimicrobial drug resistance of clinical isolates available for the African archipelago of Cabo Verde.Methods: We ...
Tamar Monteiro, Magdalena Wysocka, Elena Tellez, Ofelia Monteiro, Luzia Spencer, Elisa Veiga, Sandra Monteiro, Carine de Pina, Deisy Gonçalves, Sandrine de Pina, Antonio Ludgero-Correia, Joao Moreno, Teresa Conceição, Marta Aires-de-Sousa, Herminia de Lencastre, Laura J Gray, Manish Pareek, David R. Jenkins, Sandra Beleza, Marco R. Oggioni, Isabel Inês Araujo   +20 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Combating antimicrobial resistance: Antimicrobial stewardship program in Taiwan

, 2014
Multi-drug-resistant organisms are increasingly recognized as a global public health issue. Healthcare-associated infection and antimicrobial resistance are also current challenges to the treatment of infectious diseases in Taiwan.
張上淳, Tseng, Shu-Hui;Lee, Chun-Ming;Lin, Tzou-Yien;Chang, Shan-Chwen;Chuang, Yin-Ching;Yen, Muh-Yong;Hwang, Kao-Pin;Leu, Hsieh-Shong;Yen, Che-Chieh;Chang, Feng-Yee   +1 more
core   +1 more source

Implementation of antimicrobial stewardship to reduce antimicrobial drug resistance [PDF]

Expert Review of Anti-infective Therapy, 2020
Antimicrobial drug resistance, partly due to inappropriate use of antimicrobials, is a global health problem that causes high morbidity and mortality and inflicts enormous economic burden worldwide...
openaire   +2 more sources

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Antimicrobial resistance and virulence determinants in European Salmonella genomic island 1-positive Salmonella enterica isolates from different origins. [PDF]

, 2011
Salmonella genomic island 1 (SGI1) contains a multidrug resistance region conferring the ampicillin-chloramphenicol-streptomycin-sulfamethoxazole-tetracycline resistance phenotype encoded by bla(PSE-1), floR, aadA2, sul1, and tet(G).
Hauser, E., Dep Infectieziekten Immunologie, Advances in Veterinary Medicine, Beutlich, Janine, Rodicio, M. R., Schroeter, A., Threlfall, J., Med-Vet-Net WP21 Project Group, Janine Beutlich, Bernd Appel, Malorny, B., Trelfall, J., Andreas Schroeter, Malorny, Burkhard, Thelfall, J., Helmuth, R., Jahn, S., Burkhard Malorny, Elisabeth Hauser, Reiner Helmuth, Stephan Hühn, Dik Mevius, Beatriz Guerra, Mevius, D.J., Rodicio, M.R., Maria Rosario Rodicio, Jahn, Silke, John Threlfall, Appel, B., Rodicio Rodicio, María del Rosario, Silke Jahn, Hühn, S., Mevius, D., Beutlich, J., Rosario Rodicio, M., Guerra, B.   +35 more
core   +1 more source

Whole-genome sequencing for antimicrobial surveillance: species-specific quality thresholds and data evaluation from the network of the European Union Reference Laboratory for Antimicrobial Resistance genomic proficiency tests of 2021 and 2022

mSystems
As antimicrobial resistance (AMR) surveillance shifts to genomics, ensuring the quality of whole-genome sequencing (WGS) data produced across laboratories is critical.
Lauge Holm Sørensen, Susanne Karlsmose Pedersen, Jacob Dyring Jensen, Niamh Lacy-Roberts, Athina Andrea, Michael S. M. Brouwer, Kees T. Veldman, Yan Lou, Maria Hoffmann, Rene S. Hendriksen   +9 more
doaj   +1 more source