Results 51 to 60 of about 252,315 (298)

PlyNJ3: a three-domain endolysin with broad-spectrum anti-streptococcal activity and synergistic efficacy against multidrug-resistant Streptococcus suis

BMC Veterinary Research
Background The global spread of multidrug-resistant (MDR) bacteria prompts the exploration of innovative antimicrobial strategies. Phage lysins—peptidoglycan hydrolases known for species-specific activity and low resistance potential—offer promising ...
Jiaqi Zhao, Jingju Wang, Peizhao Han, Cai Yin, Shushu Gu, Hui Ji, Xiaoming Wang, Liping Wang, Jinhu Huang   +8 more
doaj   +1 more source

Identification of dfrA14 in two distinct plasmids conferring trimethoprim resistance in Actinobacillus pleuropneumoniae. [PDF]

, 2015
OBJECTIVES: The objective of this study was to determine the distribution and genetic basis of trimethoprim resistance in Actinobacillus pleuropneumoniae isolates from pigs in England.
Holden, MTG, Atherton, Tom, Rogers, Jon, Maskell, Duncan J, Chaudhuri, RR, Tucker, AW, Rycroft, Andrew N, Rycroft, AN, Walker, S, Tucker, A W, Weinert, LA, Weinert, Lucy A, Wren, Brendan W, Atherton, T, Bossé, J T, BRaDP1T Consortium, Chaudhuri, R R, Bossé, Janine T, Tucker, Alexander W, Chaudhuri, Roy R, Oshota, Olusegun, Walker, Stephanie, Langford, PR, Crespo, R F, Rogers, J, Rycroft, A N, Oshota, O, Fernandez Crespo, R, Wren, BW, Fernandez Crespo, Roberto, Holden, M T G, Williamson, Susanna M, Williamson, S M, Maskell, D J, Wren, B W, Williamson, SM, Weinert, L A, Li, Yanwen, Langford, P R, Maskell, DJ, Langford, Paul R, Holden, Matthew, Li, Y, Holden, Matt TG, Bosse, J   +44 more
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Antimicrobial Resistance Predicts Death in Tanzanian Children with Bloodstream Infections: A Prospective Cohort Study. [PDF]

, 2007
Bloodstream infection is a common cause of hospitalization, morbidity and death in children. The impact of antimicrobial resistance and HIV infection on outcome is not firmly established.
Roland Jureen, Langeland, Nina, Maselle, Samwel Y, Karim P Manji, Samwel Y Maselle, Mwakagile, Davis S. M., Jureen, R., Msangi, V., Bjørn Blomberg, Viola Msangi, Tamim, Bushir S, Manji, Karim P, Holberg-Petersen, Mona, Maselle, Samwel Y., Davis SM Mwakagile, Langeland, N., Mona Holberg-Petersen, Marit G Tellevik, Nina Langeland, Msangi, Viola, Jureen Roland, Jureen, Roland, Harthug, Stig, Blomberg, B., Urassa, Willy K, Urassa, Willy K., Harthug, S., Bushir S Tamim, Tamim Bushir S, Maselle, S.Y, Urassa, W.K, Tamim, Bushir S., Msangi Viola, Harthug Stig, Langeland Nina, Mwakagile Davis SM, Tellevik, M.G, Mwakagile, D.S.M, Maselle Samwel Y, Tellevik, Marit G, Manji, Karim P., Tamim, B.S, Manji, K.P, Holberg-Petersen, M., Urassa Willy K, Willy K Urassa, Manji Karim P, Holberg-Petersen Mona, Blomberg, Bjørn, Mwakagile, Davis S M, Stig Harthug, Tellevik Marit G, Blomberg Bjørn, Tellevik, Marit Gjerde   +53 more
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Whole-genome sequencing for antimicrobial surveillance: species-specific quality thresholds and data evaluation from the network of the European Union Reference Laboratory for Antimicrobial Resistance genomic proficiency tests of 2021 and 2022

mSystems
As antimicrobial resistance (AMR) surveillance shifts to genomics, ensuring the quality of whole-genome sequencing (WGS) data produced across laboratories is critical.
Lauge Holm Sørensen, Susanne Karlsmose Pedersen, Jacob Dyring Jensen, Niamh Lacy-Roberts, Athina Andrea, Michael S. M. Brouwer, Kees T. Veldman, Yan Lou, Maria Hoffmann, Rene S. Hendriksen   +9 more
doaj   +1 more source

Targeting antimicrobial drug resistance with marine natural products

, 2020
The rise and spread of antimicrobial resistance represents one of the most pressing health issues of today. Antimicrobial resistance in micro-organisms can arise due to a multiplicity of factors, including perme- ability changes in the cell membrane ...
Sousa, E., Pinto, E., Barbosa, F., Pinto, M., Kijjoa, A.   +4 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

The Burden of antimicrobial Resistance in the Americas in 2019: a Cross-Country Systematic Analysis

, 2023
BACKGROUND: Antimicrobial resistance (AMR) is an urgent global health challenge and a critical threat to modern health care. Quantifying its burden in the WHO Region of the Americas has been elusive-despite the region\u27s long history of resistance ...
Antimicrobial Resistance Collaborators
core   +3 more sources

Global trends in antimicrobial resistance on organic and conventional farms

Scientific Reports, 2023
The important hypothesis that organic livestock management reduces the prevalence of antimicrobial resistance is either fiercely supported or bitterly contested.
Eldon O. Ager, Tamilie Carvalho, Erin M. Silva, Steven C. Ricke, Jessica L. Hite   +4 more
doaj   +1 more source