Results 61 to 70 of about 4,493,796 (297)

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

FEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo, Kátia Cristiane Hall, Matheus dos Santos Fernandez, Geovanna Peter Corrêa, Rafael Guerra Lund   +4 more
wiley   +1 more source

Targeting antimicrobial drug resistance with marine natural products

, 2020
The rise and spread of antimicrobial resistance represents one of the most pressing health issues of today. Antimicrobial resistance in micro-organisms can arise due to a multiplicity of factors, including perme- ability changes in the cell membrane ...
Sousa, E., Pinto, E., Barbosa, F., Pinto, M., Kijjoa, A.   +4 more
core   +1 more source

Selective elimination of quiescent cancer cells by dequalinium chloride via ROS‐mediated ferroptosis

FEBS Open Bio, EarlyView.
Dequalinium chloride (DQ) selectively eliminates quiescent cancer cells (QCCs) by amplifying mitochondrial ROS. QCCs exhibit elevated basal ROS and limited redox‐buffering capacity, making them vulnerable to further ROS increases. DQ‐induced ROS exceeds the tolerance threshold, triggering lipid peroxidation and ferroptosis, whereas proliferating cells ...
Kotaro Miyamoto, Shiori Sakai, Minori Endo, Terigele, Mizuho Niibori, Taiki Morita, Yu Goto, Arisa Yoshida, Tomohiro Tanaka, Ning Lin, Takahiro Kuchimaru, Hiroyuki Nakamura, Masahiro Inoue, Shinae Kizaka‐Kondoh, Tetsuya Kadonosono   +14 more
wiley   +1 more source

RNase-mediated defence and its association with SCCmec in Staphylococcus aureus

Nature Communications
The rise of antibiotic resistance in Staphylococcus aureus is a major threat to global health. Resistance often emerges when bacteria acquire foreign DNA elements, such as the SCCmec cassette that makes strains resistant to nearly all β-lactam ...
Kohei Kondo, Aa Haeruman Azam, Junzo Hisatsune, Shinjiro Ojima, Kotaro Chihara, Tomohiro Nakamura, Azumi Tamura, Wakana Yamashita, Satoshi Nakano, Shoko Kutsuno, Yo Sugawara, Jumpei Uchiyama, Masayuki Amagai, Tetsuo Yamaguchi, Yoshikazu Ishii, Koichi Watashi, Yoshimasa Takahashi, Kotaro Kiga, Motoyuki Sugai   +18 more
doaj   +1 more source

BroadAMP-GPT: AI-Driven generation of broad-spectrum antimicrobial peptides for combating multidrug-resistant ESKAPE pathogens

Gut Microbes
Antimicrobial peptides (AMPs) are promising candidates to address the global antimicrobial resistance crisis, yet their traditional design remains labor-intensive and inefficient.
Yanru Li, Xianghan Xu, Xiaohui Zhang, Zhihui Xu, Jiaqi Zhao, Ruiyu Zhu, Ziyu Wang, Wei Ran, Wenqian Zhao, Ningyang Yan, Yifan Leng, Zexu Miao, Xiaomin Wang, Liping Wang, Jinxin Liu, Cong Pian, Jinhu Huang   +16 more
doaj   +1 more source

Fluorination: A strategy to tune the interactions of molecules and nanoscale systems with biological matter

FEBS Open Bio, EarlyView.
This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli, Beatrice Lucia Bona, Francesca Baldelli Bombelli   +2 more
wiley   +1 more source

Evasion of antiviral bacterial immunity by phage tRNAs

Nature Communications
Retrons are bacterial genetic elements that encode a reverse transcriptase and, in combination with toxic effector proteins, can serve as antiphage defense systems. However, the mechanisms of action of most retron effectors, and how phages evade retrons,
Aa Haeruman Azam, Kohei Kondo, Kotaro Chihara, Tomohiro Nakamura, Shinjiro Ojima, Wenhan Nie, Azumi Tamura, Wakana Yamashita, Yo Sugawara, Motoyuki Sugai, Longzhu Cui, Yoshimasa Takahashi, Koichi Watashi, Kotaro Kiga   +13 more
doaj   +1 more source

Detection of antimicrobial resistance in Glaesserella parasuis in South China using whole-genome sequencing

Frontiers in Microbiology
IntroductionGlaesserella parasuis causes Glässer’s disease in pigs, a leading cause of death in swine herds and a major contributor to economic losses in the global swine industry. Although several studies have investigated antimicrobial resistance in G.
Qianwen Ge, Qianwen Ge, Liangxing Fang, Liangxing Fang, Liangxing Fang, Yang Yu, Yang Yu, Yang Yu, Ruanyang Sun, Ruanyang Sun, Xiaoping Liao, Xiaoping Liao, Xiaoping Liao, Peng Zhang, Peng Zhang, Peng Zhang   +15 more
doaj   +1 more source

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

Towards pharmacokinetic boosting of phenoxymethylpenicillin (penicillin-V) using probenecid for the treatment of bacterial infections

Scientific Reports
In the face of increasing antimicrobial tolerance and resistance there is a global obligation to optimise oral antimicrobial dosing strategies including narrow spectrum penicillins, such as penicillin-V.
Richard C. Wilson, Alaa Riezk, Paul Arkell, Damien Ming, Ryan Armiger, Victoria Latham, Mark J. Gilchrist, Anne-Grete Märtson, William W. Hope, Alison H. Holmes, Timothy M. Rawson   +10 more
doaj   +1 more source