Results 191 to 200 of about 146,073 (265)

Enhanced strategies for cuproptosis‐like death in bacterial infection treatment

BMEMat, EarlyView.
This review summarizes and examines the molecular mechanisms underlying cuproptosis‐like death. Furthermore, multi‐strategy efficacy enhancement and potential enhancement approaches are analyzed. Abstract Copper, a classical antibacterial metal, has long been of interest and widely used in medical and public health applications.
Wenqi Wang, Bolong Xu, Ruiyuan Zhu, Hengshuo Gui, Tian Xia, Shaokai Liu, Huiyu Liu, Xianwen Wang   +7 more
wiley   +1 more source

Synergistic effect and resistance prevention activity of antimicrobial peptide MPX with Tulathromycin against <i>Actinobacillus pleuropneumoniae</i>. [PDF]

Front Microbiol
Wang H, Wang L, Zhang W, Chen B, Guo R, Zhang L, Hua Y.   +6 more
europepmc   +1 more source

Harnessing blood clot as a native scaffold for orchestrating tissue repairs and regeneration

BMEMat, EarlyView.
The blood clot, owing to its dynamic composition and unique microenvironment, holds significant yet underappreciated potential for tissue engineering. This review systematically summarizes the pathophysiology of clot formation, the key regulatory factors shaping its microenvironment, and its applications in both pre‐clinical and clinical settings ...
Gao‐peng Dang, Yu‐zhu Wang, Yi‐fei Wang, Que Bai, Jia‐xin Hao, Zhi‐ting Li, Xiao‐qing Cao, Yu Wei, Yue Feng, Ji‐hua Chen, Franklin R. Tay, Rui‐bing Wang, Jun‐ting Gu, Li‐na Niu   +13 more
wiley   +1 more source

A generative explainable model for antimicrobial peptide prediction using bidirectional temporal convolutional neural network. [PDF]

Sci Rep
Ali F, Khalid M, Alsini R, Yafoz A, Alkhalifah T, Du MZ.   +5 more
europepmc   +1 more source

Living Microbial Drugs

Chemistry – A European Journal, EarlyView.
The introduction outlines the review scope. Microbial cell factories as living drugs cover host–gut microbiota, bacteria, yeast, and other microbial systems, with comparative host advantages. Engineering strategies include synthetic circuits, quorum sensing, and memory.
Cemile Elif Özçelik, Nazlıcan Tunç, Senem Şen, Urartu Özgür Şafak Şeker   +3 more
wiley   +1 more source

High-copy plasmid engineering enhances recombinant protein and antimicrobial peptide production in Corynebacterium glutamicum. [PDF]

Microb Cell Fact
Christmann J, Sommer A, Cao P, Kohlstedt M, Goldbeck O, Riedel CU, Becker J, Wittmann C.   +7 more
europepmc   +1 more source

C‐Terminal Nucleobase Modification Amplifies Peptide‐Mediated Liposome Fusion

Chemistry – A European Journal, EarlyView.
Let's come together right now. Cationic peptides are known to promote aggregation of negatively charged liposomes through electrostatic interaction. The process is reversible: once neutrality is achieved, liposomes disaggregate. Here, we demonstrate that end‐capping peptides with nucleobases turns the process into irreversible fusion.
Laura Morbiato, Giacomo Bettin, Chiara Dalla Torre, Lorenzo Stella, Marta De Zotti   +4 more
wiley   +1 more source

Antibacterial efficacy and mechanism of the novel antimicrobial peptide lachnospirin-1 against <i>Acinetobacter baumannii</i>. [PDF]

Virulence
She P, Li M, Liu Y, Huang G, Guo S, Xiao D, Hong Y, Lu L, Wu Y.   +8 more
europepmc   +1 more source

Bioresponsive pseudoGlucosinolates (psGSLs) Release Isothiocyanates (ITCs) in the Presence of Nitroreductases

Chemistry – A European Journal, EarlyView.
This work introduces the concept of pseudoglucosinolates (psGSLs) and reports the synthesis and evaluation of nitroreductase‐responsive psGSLs. These compounds represent a complementary prodrug strategy to natural glucosinolates (GSLs) for the controlled release of isothiocyanates (ITCs), enabling bio‐responsive protein labeling, as demonstrated in ...
Claire C. Jimidar, Charity S. G. Ganskow, Mervic D. Kagho, Aishi Chakrabarti, Lorenz Wiese, Michael Zollo, Ulrike Beutling, Leona C. Cesar, Julia Morud, Kamila Bugaj, Mark Brönstrup, Stephan A. Sieber, Stephan M. Hacker, Philipp Klahn   +13 more
wiley   +1 more source

PepGraphormer: an ESM-GAT hybrid deep learning framework for antimicrobial peptide prediction. [PDF]

J Cheminform
Lin C, Xiong S, Li J, Cui F, Zhang Z, Shi H, Wei L.   +6 more
europepmc   +1 more source