Results 1 to 10 of about 10,359,574 (255)

Dynamic Visualization of Computer-Aided Peptide Design for Cancer Therapeutics [PDF]

Drug Design, Development and Therapy
Dan Hou,1– 3,* Haobin Zhou,1,2,* Yuting Tang,1,2 Ziyuan Liu,1,2 Lin Su,1,2 Junkai Guo,1,2 Janak Lal Pathak,1,2 Lihong Wu1,2 1Department of Basic Oral Medicine, School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral ...
Hou D, Zhou H, Tang Y, Liu Z, Su L, Guo J, Pathak JL, Wu L   +7 more
doaj   +4 more sources

Solubility-Aware Protein Binding Peptide Design Using AlphaFold [PDF]

Biomedicines, 2022
New protein–protein interactions (PPIs) are identified, but PPIs have different physicochemical properties compared with conventional targets, making it difficult to use small molecules.
Takatsugu Kosugi, Masahito Ohue
doaj   +2 more sources

Discovery and characterization of prolactin neutralizing monoclonal antibodies for the treatment of female-prevalent pain disorders

mAbs, 2023
Prolactin (PRL) has recently been demonstrated to elicit female-selective nociceptor sensitization and increase pain-like behaviors in female animals.
Stephanie Maciuba, Gregory D. Bowden, Harrison J. Stratton, Kazimierz Wisniewski, Claudio D. Schteingart, Juan C. Almagro, Philippe Valadon, Joshua Lowitz, Scott M. Glaser, Grace Lee, Mahdi Dolatyari, Edita Navratilova, Frank Porreca, Pierre J.M. Rivière   +13 more
doaj   +1 more source

Recent Progress on Nanocarriers for Topical-Mediated RNAi Strategies for Crop Protection—A Review

Molecules, 2023
To fulfil the growing needs of the global population, sustainability in food production must be ensured. Insect pests and pathogens are primarily responsible for one-third of food losses and harmful synthetic pesticides have been applied to protect crops
Nurzatil Sharleeza Mat Jalaluddin, Maimunah Asem, Jennifer Ann Harikrishna, Abdullah Al Hadi Ahmad Fuaad   +3 more
doaj   +1 more source

Hit-to-Lead Short Peptides against Dengue Type 2 Envelope Protein: Computational and Experimental Investigations

Molecules, 2022
Data from the World Health Organisation show that the global incidence of dengue infection has risen drastically, with an estimated 400 million cases of dengue infection occurring annually.
Norburhanuddin Johari Zaidi, Adib Afandi Abdullah, Choon Han Heh, Chun-Hung Lin, Rozana Othman, Abdullah Al Hadi Ahmad Fuaad   +5 more
doaj   +1 more source

Comprehensive evaluation of the safety and immunogenicity of a gene-deleted variant pseudorabies virus attenuated vaccine

Veterinary Research, 2022
Pseudorabies virus (PRV) variant infections have caused a substantial economic impact on swine production in the absence of new powerful candidate vaccines.
Ling Li, Yongfeng Du, Yanbin Zhang, Pengyu Li, Xinyue Liu, Xin Zhang, Jing Li, Tong Zhang, Xin Li, Dong Xiao, Peng Liu, Peng Qi, Jin Xiao   +12 more
doaj   +1 more source

Computational Ways to Enhance Protein Inhibitor Design

Frontiers in Molecular Biosciences, 2021
Two new computational approaches are described to aid in the design of new peptide-based drugs by evaluating ensembles of protein structures from their dynamics and through the assessing of structures using empirical contact potential.
Robert L. Jernigan, Kannan Sankar, Kejue Jia, Eshel Faraggi, Eshel Faraggi, Andrzej Kloczkowski, Andrzej Kloczkowski   +6 more
doaj   +1 more source

Multiple-Allele MHC Class II Epitope Engineering by a Molecular Dynamics-Based Evolution Protocol

Frontiers in Immunology, 2022
Epitopes that bind simultaneously to all human alleles of Major Histocompatibility Complex class II (MHC II) are considered one of the key factors for the development of improved vaccines and cancer immunotherapies.
Rodrigo Ochoa, Victoria Alves Santos Lunardelli, Daniela Santoro Rosa, Daniela Santoro Rosa, Alessandro Laio, Alessandro Laio, Pilar Cossio, Pilar Cossio, Pilar Cossio, Pilar Cossio   +9 more
doaj   +1 more source

Natural and Man-Made Cyclic Peptide-Based Antibiotics

Antibiotics, 2022
In recent years, an increasing number of drug-resistant bacterial strains have been identified due to the abuse of antibiotics, which seriously threatens human and animal health. Antimicrobial peptides (AMPs) have become one of the most effective weapons
Shian Lai, Quan Zhang, Lin Jin
doaj   +1 more source

Prospection of Peptide Inhibitors of Thrombin from Diverse Origins Using a Machine Learning Pipeline

Bioengineering, 2023
Thrombin is a key enzyme involved in the development and progression of many cardiovascular diseases. Direct thrombin inhibitors (DTIs), with their minimum off-target effects and immediacy of action, have greatly improved the treatment of these diseases.
Nivedha Balakrishnan, Rahul Katkar, Peter V. Pham, Taylor Downey, Prarthna Kashyap, David C. Anastasiu, Anand K. Ramasubramanian   +6 more
doaj   +1 more source