Results 21 to 30 of about 10,359,574 (255)

Targeting of interleukin-10 receptor by a potential human interleukin-10 peptide efficiently blocks interleukin-10 pathway-dependent cell proliferation

Tzu Chi Medical Journal, 2020
Objective: Human interleukin-10 (IL-10) is a dimeric and pleiotropic cytokine that plays a crucial role in cellular immunoregulatory responses. As IL-10 binds to its receptors, IL-10Ra and IL-10Rb, it will suppress or induce the downstream cellular ...
Chun-Chun Chang, Cheng-Der Liu, Sheng-Feng Pan, Wei-Han Huang, Chih-Wen Peng, Hao-Jen Hsu   +5 more
doaj   +1 more source

Antimicrobial Peptide Modifications against Clinically Isolated Antibiotic-Resistant Salmonella

Molecules, 2021
Antimicrobial peptides are promising molecules to address the global antibiotic resistance problem, however, optimization to achieve favorable potency and safety is required.
Suthee Mangmee, Onrapak Reamtong, Thareerat Kalambaheti, Sittiruk Roytrakul, Piengchan Sonthayanon   +4 more
doaj   +1 more source

A peptide filtering relation quantifies MHC class I peptide optimization [PDF]

, 2011
Major Histocompatibility Complex (MHC) class I molecules enable cytotoxic T lymphocytes to destroy virus-infected or cancerous cells, thereby preventing disease progression. MHC class I molecules provide a snapshot of the contents of a cell by binding to
Luca Cardelli, Goldstein, LD, Phillips, Andrew, Emmott, Stephen, Elliott, T, Mark Howarth, Werner, JM, Werner, Joern M., Leonard D. Goldstein, Andrew Phillips, Elliot, Tim, Dalchau, Neil, Goldstein, Leonard D., Cardelli, L, Cardelli, Luca, Tim Elliott, Dalchau, N, Emmott, S, Neil Dalchau, Howarth, M, Elliott, Tim, Leonard D Goldstein, Joern M. Werner, Phillips, A, Joern M Werner, Stephen Emmott, Howarth, Mark   +26 more
core   +1 more source

Design of Membrane Active Peptides Considering Multi-Objective Optimization for Biomedical Application

Membranes, 2022
A multitude of membrane active peptides exists that divides into subclasses, such as cell penetrating peptides (CPPs) capable to enter eukaryotic cells or antimicrobial peptides (AMPs) able to interact with prokaryotic cell envelops.
Niels Röckendorf, Christian Nehls, Thomas Gutsmann   +2 more
doaj   +1 more source

Introducing Experience Goals into Packaging Design [PDF]

, 2016
Consumer experiences are an increasingly important driving force for commerce, affecting also packaging design. Yet, experience design for packages is rarely studied.
Roto, Virpi, Virpi Roto, Markus Joutsela, Joutsela, Markus   +3 more
core   +1 more source

Improved Database Filtering Technology Enables More Efficient Ab Initio Design of Potent Peptides against Ebola Viruses

Pharmaceuticals, 2022
The rapid mutations of viruses such as SARS-CoV-2 require vaccine updates and the development of novel antiviral drugs. This article presents an improved database filtering technology for a more effective design of novel antiviral agents.
Thomas Ripperda, Yangsheng Yu, Atul Verma, Elizabeth Klug, Michellie Thurman, St Patrick Reid, Guangshun Wang   +6 more
doaj   +1 more source

Perspective: the gist of public tender for service design [PDF]

, 2018
Governments around the world are increasingly formalising design as an innovative approach to renew public services. In this development, the capabilities of external service design consultancies often play an important part, which calls for new insights
Person, Oscar, Seungho Park-Lee, Oscar Person, Park-Lee, Seungho   +3 more
core   +1 more source

Serodiagnosis of Echinococcus spp. infection: explorative selection of diagnostic antigens by peptide microarray [PDF]

, 2010
BACKGROUND: Production of native antigens for serodiagnosis of helminthic infections is laborious and hampered by batch-to-batch variation. For serodiagnosis of echinococcosis, especially cystic disease, most screening tests rely on crude or purified ...
Maag, Eva, List, C, List, C., Gottstein, Bruno, Gottstein Bruno, Felger Ingrid, Felger, Ingrid, Qi, W, Gottstein, B., Ingrid Felger, Maag Eva, Qi Weihong, Müller, N., Felger, I, Müller, Norbert, Norbert Müller, List, Claudia, Gottstein, B, Müller Norbert, Felger, I., Maag, E., Müller, N, Qi, W., Eva Maag, Bruno Gottstein, List Claudia, Claudia List, Maag, E, Qi, Weihong, Weihong Qi   +29 more
core   +2 more sources

Novel Antimicrobial Peptides Designed Using a Recurrent Neural Network Reduce Mortality in Experimental Sepsis

Antibiotics, 2022
The search and development of new antibiotics is relevant due to widespread antibiotic resistance. One of the promising strategies is the de novo design of novel antimicrobial peptides. The amino acid sequences of 198 novel peptides were obtained using a
Albert Bolatchiev, Vladimir Baturin, Evgeny Shchetinin, Elizaveta Bolatchieva   +3 more
doaj   +1 more source

Transcription of brain natriuretic peptide and atrial natriuretic peptide genes in human tissues [PDF]

, 1994
We have compared the expression of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) genes in various human tissues using a quantitative polymerase chain reaction technique.
Nguyen, T., Nemer, M., Gerbes, Alexander L., Dagnino, L.   +3 more
core   +2 more sources