Results 21 to 30 of about 15,341,682 (292)

Recent Progress on Nanocarriers for Topical-Mediated RNAi Strategies for Crop Protection—A Review

Molecules, 2023
To fulfil the growing needs of the global population, sustainability in food production must be ensured. Insect pests and pathogens are primarily responsible for one-third of food losses and harmful synthetic pesticides have been applied to protect crops
Nurzatil Sharleeza Mat Jalaluddin, Maimunah Asem, Jennifer Ann Harikrishna, Abdullah Al Hadi Ahmad Fuaad   +3 more
doaj   +1 more source

Hit-to-Lead Short Peptides against Dengue Type 2 Envelope Protein: Computational and Experimental Investigations

Molecules, 2022
Data from the World Health Organisation show that the global incidence of dengue infection has risen drastically, with an estimated 400 million cases of dengue infection occurring annually.
Norburhanuddin Johari Zaidi, Adib Afandi Abdullah, Choon Han Heh, Chun-Hung Lin, Rozana Othman, Abdullah Al Hadi Ahmad Fuaad   +5 more
doaj   +1 more source

Comprehensive evaluation of the safety and immunogenicity of a gene-deleted variant pseudorabies virus attenuated vaccine

Veterinary Research, 2022
Pseudorabies virus (PRV) variant infections have caused a substantial economic impact on swine production in the absence of new powerful candidate vaccines.
Ling Li, Yongfeng Du, Yanbin Zhang, Pengyu Li, Xinyue Liu, Xin Zhang, Jing Li, Tong Zhang, Xin Li, Dong Xiao, Peng Liu, Peng Qi, Jin Xiao   +12 more
doaj   +1 more source

Designer Natriuretic Peptides [PDF]

Journal of Investigative Medicine, 2009
Designer natriuretic peptides (NPs) are novel hybrid peptides that are engineered from the native NPs through addition, deletion, or substitution of amino acid(s) with a goal toward optimization of pharmacological actions while minimizing undesirable effects.
Candace Y W, Lee, Hsiao, Lieu, John C, Burnett   +2 more
openaire   +2 more sources

Design of novel disturbing peptides against ACE2 SARS-CoV-2 spike-binding region by computational approaches

Frontiers in Pharmacology, 2022
The SARS-CoV-2, the virus which is responsible for COVID-19 disease, employs its spike protein to recognize its receptor, angiotensin-converting enzyme 2 (ACE2), and subsequently enters the host cell. In this process, the receptor-binding domain (RBD) of
Sara Zareei, Saeed Pourmand, Massoud Amanlou, Massoud Amanlou   +3 more
doaj   +1 more source

Designing Collagen-Binding Peptide with Enhanced Properties Using Hydropathic Free Energy Predictions

Applied Sciences, 2023
Collagen is fundamental to a vast diversity of health functions and potential therapeutics. Short peptides targeting collagen are attractive for designing modular systems for site-specific delivery of bioactive agents. Characterization of peptide–protein
Kyle Boone, Aya Kirahm Cloyd, Emina Derakovic, Paulette Spencer, Candan Tamerler   +4 more
doaj   +1 more source

Designing antioxidant peptides [PDF]

Redox Report, 2014
Ionizing radiation causes the generation of damaging reactive oxygen species that lead to cellular damage and death. Organisms such as Deinococcus radiodurans have evolved mechanisms for extreme resistance to ionizing radiation, and resistance has been shown to be a consequence of protection of critical proteins from oxidative inactivation.D ...
Barbara S, Berlett, Rodney L, Levine
openaire   +2 more sources

What a Difference an Amino Acid Makes: An All-Atom Simulation Study of Nonameric Peptides in Inhibitory HLA-E/NKG2A/CD94 Immune Complexes

Frontiers in Pharmacology, 2022
MHC class I antigen E (HLA-E), a ligand for the inhibitory NKG2A/CD94 receptor of the immune system, is responsible for evading the immune surveillance in several settings, including senescent cell accumulation and tumor persistence.
Eva Prašnikar, Eva Prašnikar, Andrej Perdih, Andrej Perdih, Jure Borišek   +4 more
doaj   +1 more source

Unlocking novel therapies: cyclic peptide design for amyloidogenic targets through synergies of experiments, simulations, and machine learning.

Chemical Communications, 2023
Existing therapies for neurodegenerative diseases like Parkinson's and Alzheimer's address only their symptoms and do not prevent disease onset. Common therapeutic agents, such as small molecules and antibodies struggle with insufficient selectivity ...
Daria De Raffele, I. Ilie
semanticscholar   +1 more source

Targeting of interleukin-10 receptor by a potential human interleukin-10 peptide efficiently blocks interleukin-10 pathway-dependent cell proliferation

Tzu Chi Medical Journal, 2020
Objective: Human interleukin-10 (IL-10) is a dimeric and pleiotropic cytokine that plays a crucial role in cellular immunoregulatory responses. As IL-10 binds to its receptors, IL-10Ra and IL-10Rb, it will suppress or induce the downstream cellular ...
Chun-Chun Chang, Cheng-Der Liu, Sheng-Feng Pan, Wei-Han Huang, Chih-Wen Peng, Hao-Jen Hsu   +5 more
doaj   +1 more source