Results 21 to 30 of about 636,071 (310)

Design of novel disturbing peptides against ACE2 SARS-CoV-2 spike-binding region by computational approaches

Frontiers in Pharmacology, 2022
The SARS-CoV-2, the virus which is responsible for COVID-19 disease, employs its spike protein to recognize its receptor, angiotensin-converting enzyme 2 (ACE2), and subsequently enters the host cell. In this process, the receptor-binding domain (RBD) of
Sara Zareei, Saeed Pourmand, Massoud Amanlou, Massoud Amanlou   +3 more
doaj   +1 more source

In silico peptide-directed ligand design complements experimental peptide-directed binding for protein–protein interaction modulator discovery [PDF]

, 2020
Using the protein–protein interaction of Mcl-1/Noxa, two methods for efficient modulator discovery are directly compared. In silico peptide-directed ligand design is evaluated against experimental peptide-directed binding, allowing for the discovery of ...
Beekman, Andrew Michael, Howell, LA, Lesley A., Howell, Andrew, Beekman, Howell, Lesley Ann, Beekman, AM   +5 more
core   +1 more source

Design and analysis of peptide based nanoparticles [PDF]

, 2008
Viruses are naturally formed bionanoparticles (BNPs), ranging in size from 22-150 nm. Remarkably, small viruses are composed of one single protein chain folding into a capsid structure with icosahedral symmetry.
Raman, Senthilkumar
core   +1 more source

Designing Collagen-Binding Peptide with Enhanced Properties Using Hydropathic Free Energy Predictions

Applied Sciences, 2023
Collagen is fundamental to a vast diversity of health functions and potential therapeutics. Short peptides targeting collagen are attractive for designing modular systems for site-specific delivery of bioactive agents. Characterization of peptide–protein
Kyle Boone, Aya Kirahm Cloyd, Emina Derakovic, Paulette Spencer, Candan Tamerler   +4 more
doaj   +1 more source

Design of amyloidogenic peptide traps

Nature Chemical Biology, 2023
Abstract Segments of proteins with β-strand propensity can self associate to form amyloid fibrils associated with many diseases. These regions often adopt alternative structures in their folded states, or are intrinsically disordered in solution, making it difficult to generate binders or inhibitors with existing ...
Danny D. Sahtoe, Ewa A. Andrzejewska, Hannah L. Han, Enrico Rennella, Matthias M. Schneider, Georg Meisl, Maggie Ahlrichs, Justin Decarreau, Hannah Nguyen, Alex Kang, Paul Levine, Mila Lamb, Xinting Li, Asim K. Bera, Lewis E. Kay, Tuomas P. J. Knowles, David Baker   +16 more
openaire   +4 more sources

What a Difference an Amino Acid Makes: An All-Atom Simulation Study of Nonameric Peptides in Inhibitory HLA-E/NKG2A/CD94 Immune Complexes

Frontiers in Pharmacology, 2022
MHC class I antigen E (HLA-E), a ligand for the inhibitory NKG2A/CD94 receptor of the immune system, is responsible for evading the immune surveillance in several settings, including senescent cell accumulation and tumor persistence.
Eva Prašnikar, Eva Prašnikar, Andrej Perdih, Andrej Perdih, Jure Borišek   +4 more
doaj   +1 more source

Targeting of interleukin-10 receptor by a potential human interleukin-10 peptide efficiently blocks interleukin-10 pathway-dependent cell proliferation

Tzu Chi Medical Journal, 2020
Objective: Human interleukin-10 (IL-10) is a dimeric and pleiotropic cytokine that plays a crucial role in cellular immunoregulatory responses. As IL-10 binds to its receptors, IL-10Ra and IL-10Rb, it will suppress or induce the downstream cellular ...
Chun-Chun Chang, Cheng-Der Liu, Sheng-Feng Pan, Wei-Han Huang, Chih-Wen Peng, Hao-Jen Hsu   +5 more
doaj   +1 more source

Antimicrobial Peptide Modifications against Clinically Isolated Antibiotic-Resistant Salmonella

Molecules, 2021
Antimicrobial peptides are promising molecules to address the global antibiotic resistance problem, however, optimization to achieve favorable potency and safety is required.
Suthee Mangmee, Onrapak Reamtong, Thareerat Kalambaheti, Sittiruk Roytrakul, Piengchan Sonthayanon   +4 more
doaj   +1 more source

Serodiagnosis of Echinococcus spp. infection: explorative selection of diagnostic antigens by peptide microarray [PDF]

, 2010
BACKGROUND: Production of native antigens for serodiagnosis of helminthic infections is laborious and hampered by batch-to-batch variation. For serodiagnosis of echinococcosis, especially cystic disease, most screening tests rely on crude or purified ...
Maag, Eva, List, C, List, C., Gottstein, Bruno, Gottstein Bruno, Felger Ingrid, Felger, Ingrid, Qi, W, Gottstein, B., Ingrid Felger, Maag Eva, Qi Weihong, Müller, N., Felger, I, Müller, Norbert, Norbert Müller, List, Claudia, Gottstein, B, Müller Norbert, Felger, I., Maag, E., Müller, N, Qi, W., Eva Maag, Bruno Gottstein, List Claudia, Claudia List, Maag, E, Qi, Weihong, Weihong Qi   +29 more
core   +1 more source

Tuning material properties via peptide design and photopolymerization of self-assembled peptide based hydrogels

, 2022
Schneider, Joel P.Self-assembly of de novo designed peptides is a promising approach towards fabrication of functional materials. Hydrogels are one such class of materials, which are highly hydrated and mechanically rigid, and show potential as scaffolds
Rughani, Ronak
core   +1 more source