Results 31 to 40 of about 10,359,574 (255)

Digital Tools for Collaborative Design Processes

, 2021
Diverse practices of collaboration in design, research, teaching, or academia increasingly rely on digital online tools to facilitate processes of working and creating together. But a lot of the available digital platforms are not necessarily designed
Ibach, Merle, Greiner-Petter, Moritz
core   +1 more source

Structure-Based Design of Peptides Targeting VEGF/VEGFRs

Pharmaceuticals, 2023
Vascular endothelial growth factor (VEGF) and its receptors (VEGFRs) play a main role in the regulation of angiogenesis and lymphangiogenesis. Furthermore, they are implicated in the onset of several diseases such as rheumatoid arthritis, degenerative ...
Rossella Di Stasi, Lucia De Rosa, Luca Domenico D’Andrea   +2 more
doaj   +1 more source

Computational Design of Inhibitors Targeting the Catalytic β Subunit of Escherichia coli F_OF₁-ATP Synthase

Antibiotics, 2022
With the uncontrolled growth of multidrug-resistant bacteria, there is an urgent need to search for new therapeutic targets, to develop drugs with novel modes of bactericidal action.
Luis Pablo Avila-Barrientos, Luis Fernando Cofas-Vargas, Guillermin Agüero-Chapin, Enrique Hernández-García, Sergio Ruiz-Carmona, Norma A. Valdez-Cruz, Mauricio Trujillo-Roldán, Joachim Weber, Yasser B. Ruiz-Blanco, Xavier Barril, Enrique García-Hernández   +10 more
doaj   +1 more source

In silico peptide-directed ligand design complements experimental peptide-directed binding for protein–protein interaction modulator discovery [PDF]

, 2020
Using the protein–protein interaction of Mcl-1/Noxa, two methods for efficient modulator discovery are directly compared. In silico peptide-directed ligand design is evaluated against experimental peptide-directed binding, allowing for the discovery of ...
Beekman, Andrew Michael, Howell, LA, Lesley A., Howell, Andrew, Beekman, Howell, Lesley Ann, Beekman, AM   +5 more
core   +3 more sources

Esculentin 1-21: a linear antimicrobial peptide from frog skin with inhibitory effect on bovine mastitis-causing bacteria

, 2009
Mastitis, or inflammation of the mammary gland, is the most common and expensive illness of dairy cows throughout the world. Although stress and physical injuries may give rise to inflammation of the udders, infections by bacteria or other microorganisms
Islas-Rodriguez, A.E., Islas-Rodrìguez, A, Orioni, B., Alfonso Enrique Islas Rodriguez, MARCELLINI HERCOLANI GADDI, LUDOVICA, Barra, D, Barbara Orioni, STELLA, LORENZO, Stella, L, Mangoni, M, Orioni, B, Marcellini, L., Mangoni, M.L., Mangoni, M., Islas Rodrìguez, A, Marcellini, L, MANGONI, Maria Luisa, Lorenzo Stella, BARRA, Donatella, Barra, D., Stella, L.   +20 more
core   +1 more source

CREMP: Conformer-rotamer ensembles of macrocyclic peptides for machine learning

Scientific Data
Computational and machine learning approaches to model the conformational landscape of macrocyclic peptides have the potential to enable rational design and optimization.
Colin A. Grambow, Hayley Weir, Christian N. Cunningham, Tommaso Biancalani, Kangway V. Chuang   +4 more
doaj   +1 more source

Progressive Design of a Ranatuerin-2 Peptide from Amolops wuyiensis: Enhancement of Bioactivity and In Vivo Efficacy

Antibiotics, 2023
Antimicrobial peptides (AMPs) that exert multiple functions are considered promising candidates to combat the bacterial drug resistance crisis. Nowadays, targeted peptide modification has been widely recognised to improve biological activity and make up ...
Aifang Yao, Tianxing Liu, Yuhai Cai, Siqi Zhou, Xiaoling Chen, Mei Zhou, Chengbang Ma, Tianbao Chen, Chris Shaw, Lei Wang   +9 more
doaj   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

Computational Evolution Protocol for Peptide Design [PDF]

, 2022
Computational peptide design is useful for therapeutics, diagnostics, and vaccine development. To select the most promising peptide candidates, the key is describing accurately the peptide-target interactions at the molecular level.
Pilar Cossio, Ochoa, R., Gladich, I., Rodrigo Ochoa, Battisti, A., Alessandro Laio, Minovski, N., Anna Battisti, Cossio, P. ; https://orcid.org/, Laio, A., Nikola Minovski, Fortuna, S., Cossio, P., Rodriguez, A., Soler, M., Miguel A. Soler, Soler, M. A., Sara Fortuna, Alejandro Rodriguez Garcia, Ivan Gladich   +19 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source