Results 11 to 20 of about 10,359,574 (255)

Design and synthesis of modified peptide antibiotics of the vancomycin family [PDF]

, 2008
The ability of bacteria to constantly evolve new methods of resistance to antibacterial therapies represents a constant challenge in medicine. Emergence of strains of enterococci and S. Aureus that show resistance to vancomycin is an alarming phenomenon,
Bone, Philip Andrew
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Exploring the design applications of key emerging materials from natural sciences through a design ideation workshop [PDF]

, 2023
10th Congress of the International Association of Societies of Design Research (IASDR 2023) 9-13 October 2023, Milan, Italy202405 bcchVersion of ...
Wang, X, Tufail, M, Leung, Sai Yin, Park, Hyunyim, Tian, A, Uzma, S, Kim, KM, Kim, KwanMyung, Wang, Xinyi, Tufail, Muhammad, Li, X, Tian, Aichu, Leung, SY, Park, H, Li, Xinye, Uzma, Sahr   +15 more
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Computational Design of Macrocyclic Binders of S100B(ββ): Novel Peptide Theranostics

Molecules, 2021
S100B(ββ) proteins are a family of multifunctional proteins that are present in several tissues and regulate a wide variety of cellular processes.
Srinivasaraghavan Kannan, Pietro G. A. Aronica, Thanh Binh Nguyen, Jianguo Li, Chandra S. Verma   +4 more
doaj   +1 more source

Peptide–Protein Interactions: From Drug Design to Supramolecular Biomaterials

Molecules, 2021
The self-recognition and self-assembly of biomolecules are spontaneous processes that occur in Nature and allow the formation of ordered structures, at the nanoscale or even at the macroscale, under thermodynamic and kinetic equilibrium as a consequence ...
Andrea Caporale, Simone Adorinni, Doriano Lamba, Michele Saviano   +3 more
doaj   +1 more source

Design of Disruptors of the Hsp90–Cdc37 Interface

Molecules, 2020
The molecular chaperone Hsp90 is a ubiquitous ATPase-directed protein responsible for the activation and structural stabilization of a large clientele of proteins.
Ilda D’Annessa, Naama Hurwitz, Valentina Pirota, Giovanni Luca Beretta, Stella Tinelli, Mark Woodford, Mauro Freccero, Mehdi Mollapour, Nadia Zaffaroni, Haim Wolfson, Giorgio Colombo   +10 more
doaj   +1 more source

Design of novel disturbing peptides against ACE2 SARS-CoV-2 spike-binding region by computational approaches

Frontiers in Pharmacology, 2022
The SARS-CoV-2, the virus which is responsible for COVID-19 disease, employs its spike protein to recognize its receptor, angiotensin-converting enzyme 2 (ACE2), and subsequently enters the host cell. In this process, the receptor-binding domain (RBD) of
Sara Zareei, Saeed Pourmand, Massoud Amanlou, Massoud Amanlou   +3 more
doaj   +1 more source

Design and analysis of peptide based nanoparticles [PDF]

, 2008
Viruses are naturally formed bionanoparticles (BNPs), ranging in size from 22-150 nm. Remarkably, small viruses are composed of one single protein chain folding into a capsid structure with icosahedral symmetry.
Raman, Senthilkumar
core   +1 more source

Designing Collagen-Binding Peptide with Enhanced Properties Using Hydropathic Free Energy Predictions

Applied Sciences, 2023
Collagen is fundamental to a vast diversity of health functions and potential therapeutics. Short peptides targeting collagen are attractive for designing modular systems for site-specific delivery of bioactive agents. Characterization of peptide–protein
Kyle Boone, Aya Kirahm Cloyd, Emina Derakovic, Paulette Spencer, Candan Tamerler   +4 more
doaj   +1 more source

What a Difference an Amino Acid Makes: An All-Atom Simulation Study of Nonameric Peptides in Inhibitory HLA-E/NKG2A/CD94 Immune Complexes

Frontiers in Pharmacology, 2022
MHC class I antigen E (HLA-E), a ligand for the inhibitory NKG2A/CD94 receptor of the immune system, is responsible for evading the immune surveillance in several settings, including senescent cell accumulation and tumor persistence.
Eva Prašnikar, Eva Prašnikar, Andrej Perdih, Andrej Perdih, Jure Borišek   +4 more
doaj   +1 more source

Natriuretic peptide receptor-C regulates coronary blood flow and prevents myocardial ischemia/reperfusion injury: novel cardioprotective role for endothelium-derived C-type natriuretic peptide [PDF]

, 2004
Background: Ischemia/reperfusion (I/R) injury complicates myocardial infarction and stroke by exacerbating tissue damage and increasing risk of mortality.
Ramona Scotl, Hobbs, Adrian, Ahluwalia, Amrita, Foster, Paul, Hobbs, A., Phd Amrita Ahluwalia, Foster, P., Adrian Hobbs, Phd Paul Foster, Scotland, R., Prescott, Craig, Scotland, Ramona, Ahluwalia, A., Phd Craig Prescott, Natriuretic Peptide, Prescott, C.   +15 more
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