Results 11 to 20 of about 15,341,682 (292)
HELM-GPT: de novo macrocyclic peptide design using generative pre-trained transformer [PDF]
BioinformaticsMotivation Macrocyclic peptides hold great promise as therapeutics targeting intracellular proteins. This stems from their remarkable ability to bind flat protein surfaces with high affinity and specificity while potentially traversing the cell membrane.
Xiaopeng Xu +9 more
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Innovative Strategies and Methodologies in Antimicrobial Peptide Design [PDF]
J Funct BiomaterMultiple lines of research have led to the hypothesis that antimicrobial peptides (AMPs) are an important component of the innate immune response, playing a vital role in the defense against a wide range of infectious diseases. In this review, we explore
D. Verma, A. Tripathi, A. Thakur
semanticscholar +2 more sources
Peptide–Protein Interactions: From Drug Design to Supramolecular Biomaterials
Molecules, 2021 The self-recognition and self-assembly of biomolecules are spontaneous processes that occur in Nature and allow the formation of ordered structures, at the nanoscale or even at the macroscale, under thermodynamic and kinetic equilibrium as a consequence ...
Andrea Caporale +3 more
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Investigating Active Learning and Meta-Learning for Iterative Peptide Design [PDF]
J Chem Inf Model, 2020 Often the development of novel functional peptides is not amenable to high throughput or purely computational screening methods. Peptides must be synthesized one at a time in a process that does not generate large amounts of data. One way this method can
Rainier Barrett, A. D. White
semanticscholar +2 more sources
Dynamic Visualization of Computer-Aided Peptide Design for Cancer Therapeutics [PDF]
Drug Design, Development and TherapyDan Hou,1– 3,* Haobin Zhou,1,2,* Yuting Tang,1,2 Ziyuan Liu,1,2 Lin Su,1,2 Junkai Guo,1,2 Janak Lal Pathak,1,2 Lihong Wu1,2 1Department of Basic Oral Medicine, School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral ...
Hou D +7 more
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Inhibition of Viral Membrane Fusion by Peptides and Approaches to Peptide Design [PDF]
Pathogens, 2021 Fusion of lipid-enveloped viruses with the cellular plasma membrane or the endosome membrane is mediated by viral envelope proteins that undergo large conformational changes following binding to receptors.
Nejat Düzgüneş +2 more
doaj +2 more sources
Antibiotics, 2020 Amphibians are widely distributed on different continents, except for the polar regions. They are important sources for the isolation, purification and characterization of natural compounds, including peptides with various functions.
Guangshun Wang
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Artificial intelligence in peptide-based drug design
Drug Discovery TodayProtein-protein interactions (PPIs) are fundamental to a variety of biological processes, but targeting them with small molecules is challenging because of their large and complex interaction interfaces. However, peptides have emerged as highly promising
Tingjun Hou +2 more
exaly +2 more sources
Bioactive MaterialsPeptide molecules have design flexibility, self-assembly ability, high biocompatibility, good biodegradability, and easy functionalization, which promote their applications as versatile biomaterials for tissue engineering and biomedicine.
Gang Wei +2 more
exaly +2 more sources
mAbs, 2023 Prolactin (PRL) has recently been demonstrated to elicit female-selective nociceptor sensitization and increase pain-like behaviors in female animals.
Stephanie Maciuba +13 more
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