Results 41 to 50 of about 636,071 (310)
Pharmaceuticals, 2022 The rapid mutations of viruses such as SARS-CoV-2 require vaccine updates and the development of novel antiviral drugs. This article presents an improved database filtering technology for a more effective design of novel antiviral agents.
Thomas Ripperda +6 more
doaj +1 more source
, 2020 Using peptide sequences for the design of functional peptoids is demonstrated for a peptide-based formulation additive that was specifically tailored to solubilize the photosensitizer meta-tetra(hydroxyphenyl)-chlorin.
Eva Maron (8383839) +7 more
core +1 more source
, 2022 Recent technological innovations have led to the development of methods for the rapid identification of high-affinity macrocyclic peptides for a wide range of targets; however, it is still challenging to achieve the desired activity and membrane ...
Shuhei Yoshida (690453) +10 more
core +3 more sources
CREMP: Conformer-rotamer ensembles of macrocyclic peptides for machine learning
Scientific DataComputational and machine learning approaches to model the conformational landscape of macrocyclic peptides have the potential to enable rational design and optimization.
Colin A. Grambow +4 more
doaj +1 more source
Computational Design of Peptide Ligands for Ochratoxin A [PDF]
Toxins, 2013 In this paper, we describe a peptide library designed by computational modelling and the selection of two peptide sequences showing affinity towards the mycotoxin, ochratoxin A (OTA). A virtual library of 20 natural amino acids was used as building blocks to design a short peptide library against ochratoxin A template using the de novo design program,
Meike Heurich +2 more
openaire +6 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen +23 more
wiley +1 more source
An Enhanced Variant Designed From DLP4 Cationic Peptide Against Staphylococcus aureus CVCC 546
Frontiers in Microbiology, 2020 Insect defensins are promising candidates for the development of potent antimicrobials against antibiotic-resistant Staphylococcus aureus (S. aureus).
Bing Li +17 more
doaj +1 more source
PEPOP: Computational design of immunogenic peptides [PDF]
BMC Bioinformatics, 2008 AbstractBackgroundMost methods available to predict protein epitopes are sequence based. There is a need for methods using 3D information for prediction of discontinuous epitopes and derived immunogenic peptides.ResultsPEPOP uses the 3D coordinates of a protein both to predict clusters of surface accessible segments that might correspond to epitopes ...
Violaine Moreau +8 more
openaire +3 more sources
Enriching Peptide Libraries for Binding Affinity and Specificity Through Computationally Directed Library Design [PDF]
, 2017 Peptide reagents with high affinity or specificity for their target protein interaction partner are of utility for many important applications. Optimization of peptide binding by screening large libraries is a proven and powerful approach.
Chen, T. Scott +7 more
core +1 more source
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source