Results 41 to 50 of about 15,341,682 (292)

PPFlow: Target-Aware Peptide Design with Torsional Flow Matching [PDF]

bioRxiv
Therapeutic peptides have proven to have great pharmaceutical value and potential in recent decades. However, methods of AI-assisted peptide drug discovery are not fully explored.
Haitao Lin, Odin Zhang, Huifeng Zhao, Dejun Jiang, Lirong Wu, Zicheng Liu, Yufei Huang, Stan Z. Li   +7 more
semanticscholar   +1 more source

Design of Disruptors of the Hsp90–Cdc37 Interface

Molecules, 2020
The molecular chaperone Hsp90 is a ubiquitous ATPase-directed protein responsible for the activation and structural stabilization of a large clientele of proteins.
Ilda D’Annessa, Naama Hurwitz, Valentina Pirota, Giovanni Luca Beretta, Stella Tinelli, Mark Woodford, Mauro Freccero, Mehdi Mollapour, Nadia Zaffaroni, Haim Wolfson, Giorgio Colombo   +10 more
doaj   +1 more source

Improved Database Filtering Technology Enables More Efficient Ab Initio Design of Potent Peptides against Ebola Viruses

Pharmaceuticals, 2022
The rapid mutations of viruses such as SARS-CoV-2 require vaccine updates and the development of novel antiviral drugs. This article presents an improved database filtering technology for a more effective design of novel antiviral agents.
Thomas Ripperda, Yangsheng Yu, Atul Verma, Elizabeth Klug, Michellie Thurman, St Patrick Reid, Guangshun Wang   +6 more
doaj   +1 more source

Novel Antimicrobial Peptides Designed Using a Recurrent Neural Network Reduce Mortality in Experimental Sepsis

Antibiotics, 2022
The search and development of new antibiotics is relevant due to widespread antibiotic resistance. One of the promising strategies is the de novo design of novel antimicrobial peptides. The amino acid sequences of 198 novel peptides were obtained using a
Albert Bolatchiev, Vladimir Baturin, Evgeny Shchetinin, Elizaveta Bolatchieva   +3 more
doaj   +1 more source

Structure-Based Design of Peptides Targeting VEGF/VEGFRs

Pharmaceuticals, 2023
Vascular endothelial growth factor (VEGF) and its receptors (VEGFRs) play a main role in the regulation of angiogenesis and lymphangiogenesis. Furthermore, they are implicated in the onset of several diseases such as rheumatoid arthritis, degenerative ...
Rossella Di Stasi, Lucia De Rosa, Luca Domenico D’Andrea   +2 more
doaj   +1 more source

Computational Design of Inhibitors Targeting the Catalytic β Subunit of Escherichia coli F_OF₁-ATP Synthase

Antibiotics, 2022
With the uncontrolled growth of multidrug-resistant bacteria, there is an urgent need to search for new therapeutic targets, to develop drugs with novel modes of bactericidal action.
Luis Pablo Avila-Barrientos, Luis Fernando Cofas-Vargas, Guillermin Agüero-Chapin, Enrique Hernández-García, Sergio Ruiz-Carmona, Norma A. Valdez-Cruz, Mauricio Trujillo-Roldán, Joachim Weber, Yasser B. Ruiz-Blanco, Xavier Barril, Enrique García-Hernández   +10 more
doaj   +1 more source

Design and optimization of peptide nanoparticles [PDF]

Journal of Nanobiotechnology, 2015
Various supra-molecular structures form by self-assembly of proteins in a symmetric fashion. Examples of such structures are viruses, some bacterial micro-compartments and eukaryotic vaults. Peptide/protein-based nanoparticles are emerging in synthetic biology for a variety of biomedical applications, mainly as drug targeting and delivery systems or as
Doll, Tais A. P. F., Dey, Raja, Burkhard, Peter   +2 more
openaire   +2 more sources

Bridging machine learning and peptide design for cancer treatment: a comprehensive review

Artificial Intelligence Review
Anticancer peptides (ACPs) offer a promising alternative to traditional cancer therapies due to their specificity and reduced side effects. The development of ACPs using machine learning (ML) and deep learning (DL) follows a structured process, beginning
Khosro Rezaee, Hossein Eslami
semanticscholar   +1 more source

Progressive Design of a Ranatuerin-2 Peptide from Amolops wuyiensis: Enhancement of Bioactivity and In Vivo Efficacy

Antibiotics, 2023
Antimicrobial peptides (AMPs) that exert multiple functions are considered promising candidates to combat the bacterial drug resistance crisis. Nowadays, targeted peptide modification has been widely recognised to improve biological activity and make up ...
Aifang Yao, Tianxing Liu, Yuhai Cai, Siqi Zhou, Xiaoling Chen, Mei Zhou, Chengbang Ma, Tianbao Chen, Chris Shaw, Lei Wang   +9 more
doaj   +1 more source

Synthetic Antimicrobial Peptide Design

Molecular Plant-Microbe Interactions, 1995
To guide the design of potential plant pathogen-resistance genes, synthetic variants of naturally occurring antimicrobial gene products were evaluated. Five 20-amino acid (ESF1, ESF4, ESF5, ESF6, ESF13), one 18-amino acid (ESF12), and one 17-amino acid (ESF17) amphipathic peptide sequences were designed, synthesized, and tested with in vitro bioassays.
W A, Powell, C M, Catranis, C A, Maynard
openaire   +2 more sources