Results 191 to 200 of about 138,424 (279)

USP35 Acts as a Deubiquitinating Enzyme for ID3 to Promote Immune Escape in Colorectal Cancer

Advanced Science, EarlyView.
USP35 stabilizes ID3 expression by deubiquitinating the K2/K30 site, thereby upregulating PD‐L1 and promoting immune escape in colorectal cancer. IU1, an inhibitor of USP35 enzyme activity, has been shown to inhibit USP35, thereby accelerating ID3 degradation, enhancing CD8+ T cell killing, and reversing the immunosuppressive microenvironment ...
Wenxin Chen, Ling Wang, Hongmei Fan, Lisheng Li, Lingyu Zhang, Ruoxin Li, Fang Liu, Fuli Wen, Yunbin Ye, Chuanzhong Huang   +9 more
wiley   +1 more source

Deep-Learning Driven Identification of Novel Antimicrobial Peptides. [PDF]

Chemistry
Arino S, Sgueglia G, Leone L, Oliva R, Vecchio PD, Larrouy-Maumus G, Lombardi A, De Simone A, Nastri F.   +8 more
europepmc   +1 more source

The effect of membrane curvature on the conformation of antimicrobial peptides: implications for binding and the mechanism of action [PDF]

, 2011
Rong Chen, Alan E. Mark
openalex   +1 more source

SLC2A3‐Mediated Lactate Metabolism Promotes Lung Cancer Bone Metastasis by Modulating P53 Lactylation and Immune Evasion

Advanced Science, EarlyView.
SLC2A3 derived lactate promotes metastasis through p53 lactylation at K120 and osteoclast differentiation. Pharmacological inhibition of SLC2A3 upregulates PD‐1 expression on CD8+ T cells via lactate induced p53 lactylation, which modulates immune evasion. ABSTRACT Bone metastasis is a devastating consequence of lung cancer.
Yi Ding, Yuying Tian, Wenjie Ren, Xianglin Hu, Mengjuan Li, Bei Liu, Chen chen, Yunhan Lu, Lei Li, Wangjun Yan, Kun Li   +10 more
wiley   +1 more source

Marine-Inspired Antimicrobial Peptides Disrupt Gene Expression at the DNA Level. [PDF]

ACS Infect Dis
Beyer LI, Thoma J, Acha Alarcon L, Unksov IN, Karlsson R, Inda-Díaz JS, Tietze AA.   +6 more
europepmc   +1 more source

Dialecticsof Antimicrobial Peptides II: TheoreticalModels of Pore Formation and Membrane Protection

Oleg V. Kondrashov (1708393), Marta V. Volovik (21726234), Zaret G. Denieva (21726237), Polina K. Gifer (21726240), Timur R. Galimzyanov (6452711), Peter I. Kuzmin (18880067), Oleg V. Batishchev (15467285), Sergey A. Akimov (21726243)   +7 more
openalex   +1 more source

Targeting IL27RA Enhances Immunotherapy in Triple‐Negative Breast Cancer by Modulating Tumor Cells and the Tumor Microenvironment

Advanced Science, EarlyView.
IL27RA upregulation drives immune evasion in TNBC by suppressing MHC‐I expression and reprogramming T/NK‐cell states, establishing an immune‐excluded tumor phenotype. Targeting this epithelial‐intrinsic IL27RA–PI3K/AKT axis offers a promising strategy to overcome immunotherapy resistance.
Jiachi Xu, Qian Long, Meirong Zhou, Qitong Chen, Jing Peng, Qingchun Liang, Danhua Zhang, Hui Zhou, Wenjun Yi   +8 more
wiley   +1 more source

Study of Human Antimicrobial Peptides Active Against Some Bacteroidota Species of the Oral Cavity. [PDF]

Antibiotics (Basel)
Castagliuolo G, Notomista E, Sordillo A, Barone L, Antonini D, Renzi F, Zanfardino A, Varcamonti M.   +7 more
europepmc   +1 more source

C‑Terminal Amidation: Structural Insights intoEnhanced Antimicrobial Peptide Efficacy and Amyloidogenesis

Amit Chaudhary (3539297), Anup K. Prasad (22387873), Lisandra L. Martin (829032), Ajay Singh Panwar (3974234)   +3 more
openalex   +1 more source

Induction by Cationic Antimicrobial Peptides and Involvement in Intrinsic Polymyxin and Antimicrobial Peptide Resistance, Biofilm Formation, and Swarming Motility of PsrA in Pseudomonas aeruginosa

, 2008
W. James Gooderham, Manjeet Bains, Joseph B. McPhee, Irith Wiegand, Robert E. W. Hancock   +4 more
openalex   +1 more source