Results 91 to 100 of about 57,269 (302)

Stepwise implementation of an antimicrobial stewardship program in an open medical intensive care unit: Evaluation of antibiotic utilization and clinical outcomes

International Journal of Infectious Diseases
Objectives: Appropriate antibiotic use is crucial in intensive care units (ICUs) where patients are highly vulnerable to infection and antimicrobial resistance.
Si-Ho Kim, Min-Jin Bae, Sohui Lee, Gaeun Lee, Jaegon Ryu, Chunhwa Jung, Cheon-Hoo Jun, Yu Mi Wi   +7 more
doaj   +1 more source

Duplex Recombinase Polymerase Amplification‐Lateral Flow Assay for Rapid Visual Detection of Critical Antibiotic Resistance Genes in Escherichia coli and Klebsiella pneumoniae From Positive Blood Cultures

Journal of Clinical Laboratory Analysis, EarlyView.
This study developed a pair of duplex RPA‐LFA assays for the simultaneous detection of critical resistance genes, blaCTX‐M/mcr‐1 and blaoxa‐48‐like/blaNDM, from hemoculture samples. Under optimized conditions, duplex RPA was performed at 37°C–38°C for 25 min, followed by LFA for 10–15 min.
Variya Nemidkanam, Pattamaporn Deechart, Nuntaree Chaichanawongsaroj   +2 more
wiley   +1 more source

Interactive hygiene training using free open source software

BMJ Open Quality
Objectives Regular hygiene trainings are an important way to refresh and improve knowledge about hygiene measures and the prevention of healthcare-associated infections. We aimed to develop an e-learning course to allow healthcare workers (HCWs) to learn
Jens Maschmann, Michael Eisenmann, Vera Rauschenberger, Sarah König, Manuel Krone   +4 more
doaj   +1 more source

Point-Prevalence Survey of Antimicrobial Use in Benin Hospitals: The Need for Antimicrobial Stewardship Programs

Background: Antimicrobial resistance (AMR) is a public health concern worldwide, particularly in low-to-middle-income countries with few antimicrobial stewardship programs and few laboratories equipped for diagnosis. Methods: As point-prevalence surveys (
Carine Laurence Yehouenou, Sarah Delfosse, Dessièdé Ariane Fiogbe, Olivia Dalleur, Dalleur, Olivia, Angèle Dohou, Delfosse, Sarah, Yehouenou, Carine Laurence, Fiogbe, Dessièdé Ariane, Dohou, Angèle   +9 more
core   +1 more source

Calpain Proteases and the Evolving Signaling Network in Insect Embryonic Patterning

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Insect embryonic Dorsal‐Ventral (DV) patterning relies on the BMP and Toll pathways to different extents. Calcium‐dependent cystein proteases of the Calpain family also exert an important function to pattern the DV axis. In Drosophila, Calpain A cleaves the Cactus/IkappaB inhibitor and modifies Toll signals in ventral regions of the embryo. In Rhodnius
Alison Julio, Helena Araujo
wiley   +1 more source

Community pharmacist non-prescription dispensing of antimicrobials in the Eastern Mediterranean: regulations, implementation, and interventions

Journal of Global Antimicrobial Resistance
AIM: This study aims to critically analyze the existence and implementation of country regulations from the Eastern Mediterranean region (EMR) that aim to improve community pharmacist nonprescription dispensing of antimicrobials (CP-NPDA).
Nour Shamas, Coll de Lima Hutchison
doaj   +1 more source

Streamlining antibiotic use in community acquired pneumonia: A quality improvement initiative

Journal of Hospital Medicine, EarlyView.
Abstract Background Evidence suggests a 3‐day total duration and early transition to oral therapy is safe in hospitalized patients with community acquired pneumonia (CAP)—though such care is not standard in the United States. To implement these evidence‐based practices, a multidisciplinary group led by a hospitalist and antimicrobial stewardship ...
Claire E. Ciarkowski, Karen Howard, Hannah Imlay, Chaorong Wu, Christy L. Hopkins, Valerie M. Vaughn, Emily S. Spivak   +6 more
wiley   +1 more source

The impact of a vancomycin intervention on vancomycin‐associated nephrotoxicity in children: a quality improvement initiative

Journal of Pharmacy Practice and Research, EarlyView.
Abstract Background Vancomycin is first‐line treatment for methicillin‐resistant Staphylococcus aureus (MRSA) infections. However, despite guideline recommendations, there is no evidence that targeting vancomycin trough concentrations of ≥15 mg/L in children confers clinical benefit and is associated with vancomycin‐associated nephrotoxicity (VAN ...
Megan R. Nettleton, Hwi‐Eun Mary Shim, Joanne Abbotsford, Zoy Goff, Briony Hazelton, Matthew O'Brien, Tenielle Porter, Thomas Snelling, Daniel K. Yeoh, Asha C. Bowen, Christopher C. Blyth, Anita J. Campbell   +11 more
wiley   +1 more source

Pharmacist-led antimicrobial stewardship program in the treatment of Staphylococcus aureus bacteraemia in paediatric patients: a multivariate analysis

Infection Prevention in Practice
Summary: Background: Care bundles are a recognised strategy to improve treatment. When managed through an Antimicrobial Stewardship Program (ASP) based on the pharmacist-led program model, care bundles can be an effective tool to guide decision making ...
Stella Caroline Schenidt Bispo da Silva, Mariana Millan Fachi, Marinei Campos Ricieri, Fábio de Araújo Motta   +3 more
doaj   +1 more source

Infection on the Sidelines: Evaluating Bacteremia Rates in Device-Dependent Cardiology Patients

Antimicrobial Stewardship & Healthcare Epidemiology
Introduction: Patients with mechanical circulatory support (MCS) devices, such as ventricular assist devices (VAD) and extracorporeal membrane oxygenation (ECMO), are excluded from the National Healthcare Safety Network (NHSN) central line-associated ...
Jessica Seidelman, Heather Pena, Alexandria Hunt, Brittain Wood, Polly Padgette, Erin Gettler, Jeffrey Keenan, Deverick Anderson, Becky Smith   +8 more
doaj   +1 more source