Results 91 to 100 of about 1,118,223 (258)

Comparison of in vitro antimicrobial susceptibility between mucoid and non-mucoid Pseudomonas aeruginosa and its guiding value for antibiotic therapy

Microbiology Spectrum
The aim of the study was to compare in vitro antimicrobial susceptibility between mucoid and non-mucoid Pseudomonas aeruginosa and its guiding value for antibiotic therapy.
Yun Wu, Aixin Wang, Jinghan Qu, Ruirui Ma, Wei Kang, Yali Liu, Yingchun Xu   +6 more
doaj   +1 more source

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

Advanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella   +25 more
wiley   +1 more source

The Impact of Information Quality of Antimicrobial Susceptibility Test Report on the Rational Antimicrobial Use: A Retrospective Study

, 2023
Ming Wei,1 Yanting Wang,2 Xinping Zhang,2 Xiaojun Xu,3 Yan Li3 1The Department of Medical Administration, Tianjin Cancer Hospital Airport Hospital, Tianjin, People’s Republic of China; 2School of Medicine and Health Management, Huazhong University of ...
Wei M, Li Y, Zhang X, Wang Y, Xu X
core  

Clinical evaluation of EUCAST rapid antimicrobial susceptibility testing in Gram-negative bacilli bloodstream infections: a real-world retrospective study

Frontiers in Microbiology
Background/ObjectivesRapid antimicrobial susceptibility testing (RAST) performed directly from positive blood cultures may facilitate earlier optimization of antimicrobial therapy in bloodstream infections.
Peng-Peng Tian, Hua-Wei Yi, Hua-Wei Yi, Tian Wang, Hui Yang, Meng-Yao Du, Li-Sha Zhu, Xian-Mo Wang, Liang-Cai Xie, Li Wan, Tian Tian   +10 more
doaj   +1 more source

Lipidomic Profile Reconstruction of Therapeutic Membrane Targets Using Physics‐Based Optimization with Limited Activity Data

Advanced Science, EarlyView.
Using a minimal set of experimentally labeled antimicrobial and non‐antimicrobial peptides, we reconstruct the effective lipid composition of a pathogenic membrane ‐demonstrated at the example of bacterial membranes‐ through a physics‐based evolutionary molecular dynamics (Evo‐MD) approach. Optimization based on peptide insertion reveals broad‐spectrum
Maximilian Krebs, Herre Jelger Risselada
wiley   +1 more source

Rapid Multiplex Antimicrobial Resistance Profiling and Bacterial Identification by LAP‐MALDI Mass Spectrometry Biotyping

Advanced Science, EarlyView.
Liquid atmospheric pressure matrix‐assisted laser desorption/ionization (LAP‐MALDI) mass spectrometry (MS) provides multiplexed biotyping of microbial cultures using a fast and simple workflow. This is demonstrated for clinically relevant bacteria, resulting in accurate antimicrobial resistance (AMR) detection, speciation by MS/MS sequencing and ...
Lily R. Adair, Shabnam Iyer, Ian M. Jones, Rainer Cramer   +3 more
wiley   +1 more source

Rhoifolin Alleviates Ulcerative Colitis by Targeting NMNAT1 and Activating SIRT1‐FOXO1 Signaling to Enhance ILC3s Effector Function

Advanced Science, EarlyView.
Rhoifolin directly targets NMNAT1, thereby activating nicotinamide salvage pathway and promoting intracellular NAD+ biosynthesis. Elevated NAD+ levels enhance SIRT1 activity, leading to FOXO1 deacetylation and nuclear translocation. Nuclear FOXO1 subsequently binds to the IL‐22 promoter, upregulating IL‐22 transcription and potentiating ILC3 effector ...
Hongqiong Yang, Yishu Zhang, Sijia Feng, Xiaoqing Ma, Jiayi Feng, Junwei Wang, Jialin Gao, An Pan, Dapeng Wu, Kang Ding, Caijuan Zheng, Qi Lv, Lihong Hu   +12 more
wiley   +1 more source

Age Specific Aetiological Agents of Diarrhoea in Hospitalized Children Aged Less than five years in Dar es Salaam, Tanzania. [PDF]

, 2011
\ud This study aimed to determine the age-specific aetiologic agents of diarrhoea in children aged less than five years. The study also assessed the efficacy of the empiric treatment of childhood diarrhoea using Integrated Management of Childhood Illness
Matee, Mecky I., Langeland, Nina, Sabrina J Moyo, Jesse Kitundu, Mylvaganam Haima, Gro, N., Myrmel Helge, Samuel Y Maselle, Mecky I Matee, Haima Mylvaganam, Mylvaganam, Haima, Moyo, Sabrina John, Myrmel, H., Langeland Nina, Maselle, Samwel Y., Mylvaganam, H., Njølstad, Gro, Kitundu, J., Langeland, N., Matee, Mecky I, Gro Njolstad, Matee, M.I., Nina Langeland, Maselle, S.Y., Myrmel, Helge, Maselle, Samuel Y, Moyo, S.J., Kitundu, Jesse, Kitundu Jesse, Matee Mecky I, Helge Myrmel, Njolstad Gro, Moyo Sabrina J, Gro, Njolstad, Maselle Samuel Y, Moyo, Sabrina J   +35 more
core   +2 more sources

Artificial Intelligence‐Guided Phenotypic Drug Repurposing Against Streptococcus pneumoniae

Advanced Science, EarlyView.
Integrated artificial intelligence (AI) ensembles identify highly potent repurposed drugs against Streptococcus pneumoniae. Prospective virtual screening of 6747 drugs uncovers nine active candidates, including thiostrepton. This drug exhibits low picomolar potency and bypasses established resistance in multidrug‐resistant strains, demonstrating an ...
Joshua S. Fitch, Muhammad D. Ariadi, Min Jung Kwun, Leonie Howells, Saiveth Hernandez‐Hernandez, Nicholas J. Croucher, Pedro J. Ballester   +6 more
wiley   +1 more source

Is Increased Biofilm Formation Associated with Decreased Antimicrobial Susceptibility? A Systematic Literature Review

Microorganisms
Biofilm formation is a key factor in microbial survival and persistence, often contributing to reduced antimicrobial susceptibility. This systematic literature review investigates whether increased biofilm formation correlates with decreased antibiotic ...
Abhinav Madduri, Lobke Vanommeslaeghe, Tom Coenye   +2 more
doaj   +1 more source