Results 181 to 190 of about 122,863 (262)

Clinical Relevance of Antimicrobial Susceptibility Testing Methods in Carbapenem-Resistant <i>Acinetobacter baumannii</i> Pneumonia: A Secondary Analysis of a Randomized Controlled Trial. [PDF]

Antibiotics (Basel)
Ungthammakhun C, Vasikasin V, Cheh-Oh N, Santimaleeworagun W, Changpradub D.   +4 more
europepmc   +1 more source

Substrate‐Selective Inhibition of the SARS‐CoV‐2 Papain‐Like Protease: Inhibition of Hydrolysis of Human Over Viral Substrates

Chemistry – A European Journal, EarlyView.
The SARS‐CoV‐2 papain‐like protease (PLpro) is a medicinal chemistry target. Here we report mass spectrometry assays employing oligopeptide substrates based on the sequences of the viral polyproteins 1a/1ab and on an ISG15‐modified human protein, which enabled the identification of substrate‐selective PLpro inhibitors.
Sakshi Sharma, Peter A. C. Wing, Wojtek Treyde, Shyam Basak, Simeon D. Draganov, Taylah Andrews‐Clark, Eidarus Salah, Petra Lukacik, Claire Strain‐Damerell, Adán Pinto‐Fernández, Martin A. Walsh, Fernanda Duarte, Christopher J. Schofield, Lennart Brewitz   +13 more
wiley   +1 more source

Hybrid Macrocyclic Peptides — Synthetic Strategies to Diversify and Cyclize Peptide Libraries in Phage Display Selections

Chemistry – A European Journal, EarlyView.
Hybrid macrocyclic peptides unite genetically encoded peptide libraries with the structural complexity of synthetic small molecules. This Review critically analyzes phage‐compatible cyclization and diversification chemistries, highlights emerging opportunities beyond traditional cysteine‐based approaches, and outlines how future advances may enable the
Titia Rixt Oppewal, Clemens Mayer
wiley   +1 more source

Amoxicillin-metronidazole disk for antimicrobial susceptibility testing of subgingival bacteria. [PDF]

J Oral Microbiol
Jensen AB, Frandsen Lau E, Nørskov-Lauritsen N.   +2 more
europepmc   +1 more source

Effects of Trimethoprim on Three Previously Proposed Putative Biomarkers for OCT2/MATE‐Mediated Renal Drug‐Drug Interactions in Healthy Volunteers

Clinical Pharmacology &Therapeutics, EarlyView.
Regulatory agencies request the assessment of the potential of new drugs to cause transporter‐mediated drug‐drug interactions (DDI). This assessment can be improved by integrating endogenous biomarkers during drug development. Regarding the renal excretion of drugs such as metformin, the organic cation transporter (OCT) 2 and multidrug and toxin ...
Jana Picurová, Fabian Müller, Daniel Auge, Jörg König, Martin F. Fromm, Arne Gessner   +5 more
wiley   +1 more source

Performance of direct-from-blood culture bottle rapid phenotypic antimicrobial susceptibility testing for Gram-negative bacteremia at a children's hospital. [PDF]

JAC Antimicrob Resist
Nanishi E, Campigotto A, Tadros M.
europepmc   +1 more source

Fecal Microbiota Transplantation and Microbiota‐Based Therapeutics in Allogeneic Hematopoietic Stem Cell Transplantation: Current Evidence and Future Directions

Clinical Pharmacology &Therapeutics, EarlyView.
The intestinal microbiome is a key regulator of immune homeostasis, metabolism, and epithelial barrier integrity. In patients with malignant hematological diseases, particularly those undergoing hematopoietic stem cell transplantation, microbiome perturbations by reduced diversity, pathobiont expansion, and loss of beneficial metabolites are common as ...
Bálint Gergely Szabó, Dorina Korózs, Michal Bator, Krisztina Jeszenszky, Viktor Lakatos, László Gopcsa, Péter Reményi, János Sinkó   +7 more
wiley   +1 more source

In Vitro Therapeutic Efficacy of Furazolidone for Antimicrobial Susceptibility Testing on <i>Campylobacter</i>. [PDF]

Antibiotics (Basel)
Moya-Salazar J, Terán-Vásquez A, Salazar-Hernandez R, Rojas-Zumaran V, Goicochea-Palomino EA, Moya-Salazar MM, Contreras-Pulache H.   +6 more
europepmc   +1 more source

Z‐Scheme BiOCl‐Based Photocatalysts: Recent Advances in Designing, Structural Engineering, Formation Mechanisms, and High Performance Photocatalytic Environmental Remediation

EcoEnergy, EarlyView.
This review deals with the recent advancements in design and engineering of BiOCl‐based Z‐scheme photocatalysts with emphasis on tailoring of structural, optoelectronic properties and heterojunction assembly for environmental applications including photodegradation of industrial organic waste, pharmaceuticals, pesticides, herbicides, toxic heavy metals,
Sakshi Sharma, Neha Kaushal, Victor Ezebuiro, Monika Sindhu, Lovepreet Singh, Yugesh Singh Thakur, Hendrik C. Swart, Jai Prakash   +7 more
wiley   +1 more source

Optimizing bloodstream infection diagnosis: Implementation of the EUCAST Rapid Antimicrobial Susceptibility Testing (RAST) with automated digital imaging. [PDF]

Eur J Clin Microbiol Infect Dis
Aparicio-Calvente I, Pontón-Martínez P, Guédez-López GV, Nuez-Zaragoza E, Casabella A, Capilla S, Espasa M, Alguacil-Guillén M.   +7 more
europepmc   +1 more source