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In the last couple of years, the awareness of climate change and high pollution levels have raised our sense of ecological responsibility [...]
Helena P. Felgueiras
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We are living in a time of enormous risk. Years of antibiotic overuse and misuse has contributed to a global threat, where an increase in antibiotic resistant bacteria are contributing to approximately 700,000 deaths per year. International institutions such as the World Health Organization (WHO) and the UK government are calling for new antibiotics ...
Birnbaum, H, Roughley, M, D'Sa, R
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The rapid increase in drug-resistant infections has presented a serious challenge to antimicrobial therapies. The failure of the most potent antibiotics to kill “superbugs” emphasizes the urgent need to develop other control agents. Here we review the history and new development of antimicrobial peptides (AMPs), a growing class of natural and synthetic
Ali Adem Bahar, Dacheng Ren
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Antimicrobial Chemokines [PDF]
Chemokines are best known for their classic leukocyte chemotactic activity, which is critical for directing the immune response to sites of infection and injury. However, recent studies have suggested that at least some chemokines may also interfere with infectious agents directly.
Yung, Sunny C., Murphy, Philip M.
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Antimicrobial peptides and proteins (AMPs) are a diverse class of naturally occurring molecules that are produced as a first line of defense by all multicellular organisms. These proteins can have broad activity to directly kill bacteria, yeasts, fungi, viruses and even cancer cells.
Zhang, Ling-juan, Gallo, Richard L.
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Can we prevent antimicrobial resistance by using antimicrobials better? [PDF]
Since their development over 60 years ago, antimicrobials have become an integral part of healthcare practice worldwide. Recently, this has been put in jeopardy by the emergence of widespread antimicrobial resistance, which is one of the major problems ...
Brown +27 more
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Anti-microbial Use in Animals: How to Assess the Trade-offs [PDF]
Antimicrobials are widely used in preventive and curative medicine in animals. Benefits from curative use are clear – it allows sick animals to be healthy with a gain in human welfare.
Acar J. F. +12 more
core +2 more sources
Use of Estimating Equations for Dosing Antimicrobials in Patients with Acute Kidney Injury Not Receiving Renal Replacement Therapy. [PDF]
Acute kidney injury (AKI) can potentially lead to the accumulation of antimicrobial drugs with significant renal clearance. Drug dosing adjustments are commonly made using the Cockcroft-Gault estimate of creatinine clearance (CLcr). The Modified Jelliffe
Awdishu, Linda +5 more
core +2 more sources
Expert consensus regarding drivers of antimicrobial stewardship in companion animal veterinary practice: a Delphi study [PDF]
Antimicrobial resistance (AMR) is a global challenge facing both human and animal healthcare professionals; an effective response to this threat requires a ‘One-Health’ approach to antimicrobial stewardship (AMS) to preserve important antibiotics for ...
Cinquepalmi +5 more
core +4 more sources
Earlier In Vitro Viral Production With SARS-CoV-2 Alpha Than With Beta, Gamma, B, or A.27 Variants
Since its emergence in China at the end of 2019, SARS-CoV-2 has rapidly spread across the world to become a global public health emergency. Since then, the pandemic has evolved with the large worldwide emergence of new variants, such as the Alpha (B.1.1 ...
Samuel Lebourgeois +21 more
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