Characterization and epitope mapping of human monoclonal antibodies to PDC-E2, the immunodominant autoantigen of primary biliary cirrhosis [PDF]
Further to define the epitopes of PDC-E2, the major autoantigen in primary biliary cirrhosis (PBC), we have developed and characterized five human monoclonal antibodies. These antibodies were derived by fusing a regional hepatic lymph node from a patient
Bassendine +49 more
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Antimitochondrial antibody -M2 positive autoimmune hepatitis during standard of care for chronic hepatitis C. [PDF]
The current standard of care (SoC) for chronic hepatitis C, i.e. the combination of a pegylated-interferon (PEG-IFN) with ribavirin (RBV), may activate underlying autoimmune conditions.
ALESSI, Nicola +2 more
core +1 more source
Thyroid Dysfunction in Primary Biliary Cholangitis: A Comparative Study at Two European Centers [PDF]
open10siOBJECTIVES: Primary biliary cholangitis (PBC) is often associated with other autoimmune diseases, but little is known about the influence of thyroid disease (TD) on the natural history of PBC.
core +1 more source
Autoimmune hepatitis type 2 associated with an unexpected and transient presence of primary biliary cirrhosis-specific antimitochondrial antibodies: a case study and review of the literature. [PDF]
Invernizzi P +9 more
europepmc +3 more sources
Breach of tolerance: primary biliary cirrhosis. [PDF]
In primary biliary cirrhosis (PBC), the breach of tolerance that leads to active disease involves a disruption in several layers of control, including central tolerance, peripheral anergy, a liver tolerance effect, and the action of T regulatory cells ...
Chang, Christopher +3 more
core +2 more sources
Obeticholic acid for the treatment of primary biliary cholangitis in adult patients: clinical utility and patient selection. [PDF]
Primary biliary cholangitis (PBC), previously known as primary biliary "cirrhosis", is a rare autoimmune liver disease characterized by the hallmark autoantibodies to mitochondrial antigens and immune-mediated destruction of small bile duct epithelial ...
Bowlus, Christopher L
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Third Brazilian consensus for autoantibodies screening in HEp-2 cells (ANA) : recommendations for standardization of autoantibodies screening trial in HEp-2 cells, quality control and clinical associations [PDF]
Objetivo: O 3º Consenso Brasileiro para pesquisa de autoanticorpos em Células HEp-2 (FAN) teve como propósito avaliar as dificuldades de implantação do 2º Consenso ocorrido no ano de 2002, discutir estratégias para controlar a qualidade do ensaio e ...
Andrade, Luis Eduardo Coelho +33 more
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Severe drug-induced liver injury associated with prolonged use of Linezolid [PDF]
This study aims to describe a patient developing concomitant severe liver failure and lactic acidosis after long-term treatment with linezolid. A 55-year-old Caucasian woman developed concomitant severe liver failure and lactic acidosis after a treatment
Benoit, Dominique +7 more
core +1 more source
Hepatitis in a patient with SLE: Is it autoimmune hepatitis? [PDF]
In a patient with systemic lupus erythematosus (SLE), we considered the diagnosis of autoimmune hepatitis (AIH) in view of raised serum aminotransferases, hypergammaglobulinaemia, antinuclear antibodies (titre 1:10240), seronegative of markers for viral ...
Engelkens, H.J.H. (Herman) +5 more
core +1 more source
This issue of eMedRef provides information to clinicians on the pathophysiology, diagnosis, and therapeutics of microscopic ...
Short, Matthew W.
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