Results 21 to 30 of about 4,444 (157)

Primary biliary cirrhosis in a rheumatoid arthritis patient treated with rituximab, a case-based review [PDF]

, 2011
Primary biliary cirrhosis (PBC) is an autoimmune disease in which intrahepatic bile ducts are targeted by an immune-mediated injury. This disease tends to progress to fibrosis and cirrhosis with hepatic failure. The authors report a case of a 50-year-old
Canhão, H, Fonseca, JE, Pereira da Silva, JA, Polido-Pereira, J, Rodrigues, AM, Saraiva, F   +5 more
core   +1 more source

Trends in Primary Biliary Cholangitis: Prospective Cohort Study From the European Reference Network Registry (R‐LIVER)

United European Gastroenterology Journal, EarlyView.
ABSTRACT Background and Aims The European Reference Network on Hepatological Diseases (ERN RARE‐LIVER) is a Europe‐wide network for centers of excellence in the management of rare liver diseases. We aimed to evaluate the current diagnostic and therapeutic trends of primary biliary cholangitis (PBC).
A. Gerussi, E. Nofit, D. P. Bernasconi, C. Kroll, F. Groß, I. Schregel, A. Marini, L. Cristoferi, F. Malinverno, M. Papp, G. Dalekos, E. Rigopoulou, M. K. Janik, P. Milkiewitz, H. Ytting, A. Leburgue, F. Braun, C. Casar, M. Sebode, A. Lohse, B. Hansen, M. Carbone, C. Schramm, P. Invernizzi   +23 more
wiley   +1 more source

Mixed mucus-secreting and oncocytic carcinoma of the thyroid - Pathologic, histochemical, immunohistochemical, and ultrastructural study of a case [PDF]

, 2000
We report a carcinoma that is, to the best of our knowledge, the first case of a mixed mucus-secreting and oncocytic carcinoma of the thyroid. We also describe the histochemical, immunohistochemical, and ultrastructural features of this tumor.
Erba, S, Finzi, G, La Rosa, S, Sessa, F, Uccella, S.   +4 more
core   +1 more source

T lymphocytes from patients with primary biliary cirrhosis produce reduced amounts of lymphotoxin, tumor necrosis factor and interferon-gamma upon mitogen stimulation [PDF]

, 1992
Primary biliary cirrhosis (PBC) is considered an autoimmune disease characterized by destruction of small intrahepatic bile ducts by lymphocytes. Altered functions of these lymphocytes might reflect an abnormal immune response leading to tissue damage ...
Eisenburg, Josef, Hoffmann, Robert M., Jung, Maria C., Messer, Gerald, Möller, Achim, Paumgartner, Gustav, Riethmüller, Gert, Spengler, Ulrich, Weiss, Elisabeth H., Zachoval, Reinhard   +9 more
core   +1 more source

Prognostic Significance of Bile Duct Loss in Early‐Stage Primary Biliary Cholangitis: A Long‐Term Observational Study

Hepatology Research, Volume 55, Issue 12, Page 1621-1630, December 2025.
Bile duct loss on liver biopsy predicts future liver‐related events in early‐stage primary biliary cholangitis, even in patients with preserved liver function. This finding highlights the prognostic value of histological bile duct assessment at diagnosis and may guide early risk stratification and management decisions.
Taiki Okumura, Takefumi Kimura, Takanobu Iwadare, Shun‐Ichi Wakabayashi, Hiroyuki Kobayashi, Yuki Yamashita, Satoru Joshita, Michiharu Komatsu, Naoki Tanaka, Akihiro Matsumoto, Tomoyuki Nakajima, Mai Iwaya, Masahiro Umemura, Kazuhito Kawata, Kenichi Harada, Takeji Umemura   +15 more
wiley   +1 more source

Dendritic Cell‐Depleted Mice Develop the Autoimmune Biliary Disease That Serologically and Pathogenically Models Human Primary Biliary Cholangitis

Hepatology Research, Volume 55, Issue 11, Page 1471-1485, November 2025.
ABSTRACT Aim Primary biliary cholangitis (PBC) is an autoimmune liver disease marked by progressive bile duct damage, leading to bile retention. Dendritic cells (DCs), as antigen‐presenting cells, are crucial for immune regulation, and their dysfunction is linked to autoimmunity.
Jiaqi Zhang, Ryo Nakagawa, Qingpeng Xu, Ke Hu, Lin Ru, Hayato Nakagawa, Yoshihiro Hirata   +6 more
wiley   +1 more source

Lymphapheresis in organ transplantation: preliminary report. [PDF]

, 1982
Reduction of lymphoid tissue by splenectomy and/or thymectomy has been used as a part of immunosuppression in organ transplantation (4). More recently Walker (7), Johnson (2), Franksson (1) and Starzl (5,6) and their associates have shown that chronic ...
Iwaki, Y, Iwatsuki, S, Kano, T, Klintmalm, G, Krams, AK, Starzl, TE   +5 more
core  

A Common Variant in CLDN14 is Associated with Primary Biliary Cirrhosis and Bone Mineral Density. [PDF]

, 2016
Primary biliary cirrhosis (PBC), a chronic autoimmune liver disease, has been associated with increased incidence of osteoporosis. Intriguingly, two PBC susceptibility loci identified through genome-wide association studies are also involved in bone ...
Bian, Zhaolian, Chen, Haoyan, Gershwin, M Eric, Jiang, Xiang, Li, Enling, Li, Zhiqiang, Lian, Min, Liao, Wilson, Ma, Xiong, Miao, Qi, Seldin, Michael F, Shi, Yongyong, Tang, Ruqi, Wang, Qixia, Wang, Zhaoyue, Wei, Yiran, Yang, Fan, Yang, Yue, Zhang, Haiyan   +18 more
core   +2 more sources

Bidirectional causal links between diabetes mellitus and autoimmune liver diseases: Insights from Mendelian randomization

Journal of Diabetes Investigation, Volume 16, Issue 10, Page 1929-1940, October 2025.
This study employed a two‐sample Mendelian randomization approach to assess the causal relationship between autoimmune liver diseases (AILD) and diabetes mellitus. We found that genetic predispositions to primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC) were significantly associated with an increased risk of type 1 diabetes ...
Haixia Kuang, Jian Wu, Tao Huang, Kai Yan, Xiaoyun Hu, Ying Wu, Yudi Wang, Zhihong Wu, Xiao Chen, Gaole Yuan   +9 more
wiley   +1 more source

Immunosuppressive Therapy in Immune-Mediated Liver Disease in the Non-Transplanted Patient [PDF]

, 2013
Autoimmune liver disease management goals are primarily slowing disease progression and symptomatic treatment. There are few options for curative medical management other than transplant for a spectrum of autoimmune liver disease that encompasses ...
Abhyankar, Anita, Bonder, Alan, Tapper, Elliot   +2 more
core   +2 more sources