Results 61 to 70 of about 4,667 (242)

Prognostic Significance of Bile Duct Loss in Early‐Stage Primary Biliary Cholangitis: A Long‐Term Observational Study

Hepatology Research, Volume 55, Issue 12, Page 1621-1630, December 2025.
Bile duct loss on liver biopsy predicts future liver‐related events in early‐stage primary biliary cholangitis, even in patients with preserved liver function. This finding highlights the prognostic value of histological bile duct assessment at diagnosis and may guide early risk stratification and management decisions.
Taiki Okumura, Takefumi Kimura, Takanobu Iwadare, Shun‐Ichi Wakabayashi, Hiroyuki Kobayashi, Yuki Yamashita, Satoru Joshita, Michiharu Komatsu, Naoki Tanaka, Akihiro Matsumoto, Tomoyuki Nakajima, Mai Iwaya, Masahiro Umemura, Kazuhito Kawata, Kenichi Harada, Takeji Umemura   +15 more
wiley   +1 more source

Evaluation of immunoserological detection of anti-liver kidney microsomal, anti-soluble liver antigen and anti-mitochondrial antibodies

Scientific Reports, 2023
Autoantibodies are the diagnostic hallmark of autoimmune liver diseases. Indirect immunofluorescence (IFT) is the reference method for the detection of anti-mitochondrial antibodies (AMA) and anti-liver kidney microsomal type-1 (anti-LKM1) antibodies ...
Alejandro Campos-Murguia, Nicole Henjes, Stephanie Loges, Heiner Wedemeyer, Elmar Jaeckel, Richard Taubert, Bastian Engel   +6 more
doaj   +1 more source

Anti-Mitochondrial Antibody Titers Decrease Over Time in Primary Biliary Cholangitis Patients With Ursodeoxycholic Acid Therapeutic Response: A Cohort Study Followed Up to 28 Years

Frontiers in Immunology, 2022
BackgroundHow anti-mitochondrial antibody (AMA) and liver biochemistry levels change in primary biliary cholangitis (PBC) patients treated with ursodeoxycholic acid (UDCA) remains unclear.MethodsA 28-year cohort of 157 PBC patients was conducted ...
Ming-Ling Chang, Ming-Ling Chang, Wei-Ting Chen, Tien-Ming Chan, Tien-Ming Chan, Cheng-Yu Lin, Ming-Yu Chang, Shiang-Chi Chen, Rong-Nan Chien, Rong-Nan Chien   +9 more
doaj   +1 more source

Multiple sclerosis-like neurological manifestations in a coeliac patient: nothing is as it seems [PDF]

, 2012
Cobalamin (vitamin B(12)) deficiency occurs with several disorders, involving different organs and systems, including blood, bowel, nervous system and eyes.
CARROCCIO, Antonio, D'ALCAMO, Alberto, DI STEFANO, Laura, MANSUETO, Pasquale   +3 more
core   +1 more source

Dendritic Cell‐Depleted Mice Develop the Autoimmune Biliary Disease That Serologically and Pathogenically Models Human Primary Biliary Cholangitis

Hepatology Research, Volume 55, Issue 11, Page 1471-1485, November 2025.
ABSTRACT Aim Primary biliary cholangitis (PBC) is an autoimmune liver disease marked by progressive bile duct damage, leading to bile retention. Dendritic cells (DCs), as antigen‐presenting cells, are crucial for immune regulation, and their dysfunction is linked to autoimmunity.
Jiaqi Zhang, Ryo Nakagawa, Qingpeng Xu, Ke Hu, Lin Ru, Hayato Nakagawa, Yoshihiro Hirata   +6 more
wiley   +1 more source

A Common Variant in CLDN14 is Associated with Primary Biliary Cirrhosis and Bone Mineral Density. [PDF]

, 2016
Primary biliary cirrhosis (PBC), a chronic autoimmune liver disease, has been associated with increased incidence of osteoporosis. Intriguingly, two PBC susceptibility loci identified through genome-wide association studies are also involved in bone ...
Bian, Zhaolian, Chen, Haoyan, Gershwin, M Eric, Jiang, Xiang, Li, Enling, Li, Zhiqiang, Lian, Min, Liao, Wilson, Ma, Xiong, Miao, Qi, Seldin, Michael F, Shi, Yongyong, Tang, Ruqi, Wang, Qixia, Wang, Zhaoyue, Wei, Yiran, Yang, Fan, Yang, Yue, Zhang, Haiyan   +18 more
core   +2 more sources

Characterization of Autoantibodies against the E1𝜶 Subunit of Branched-Chain 2-Oxoacid Dehydrogenase in Patients with Primary Biliary Cirrhosis

International Journal of Hepatology, 2012
Primary biliary cirrhosis (PBC) is characterized by antimitochondrial antibodies (AMAs) that react with the lipoyl-containing E2 subunits of 2-oxoacid dehydrogenase complexes such as BCOADC and PDC.
Tsutomu Mori, Hiromasa Ohira, Masahito Kuroda, Masaki Kato, Yoshiki Yamaguchi, Hideo Kochi   +5 more
doaj   +1 more source

FOXP3+T-REGULATORY LYMPHOCYTES AND AUTOANTIBODIES IN PATIENTS WITH ARTERIAL HYPERTENSION, ASSOCIATED WITH DIABETES MELLITUS TYPE 2 AND IMPAIRED GLUCOSE TOLERANCE

Медицинская иммунология, 2014
When studying patients with an association of arterial hypertension and type 2 diabetes mellitus, we have shown a lower number of FoxP3+T-regulatory cells, as well as elevated levels of anti-myocardial antibodies and autoantibodies to nuclear antigens ...
I. V. Kologrivova, T. E. Suslova, O. A. Koshelskaya, I. V. Vinnizkaya, O. A. Trubacheva, N. M. Zheltonogova, A. M. Gusakova   +6 more
doaj   +1 more source

Bidirectional causal links between diabetes mellitus and autoimmune liver diseases: Insights from Mendelian randomization

Journal of Diabetes Investigation, Volume 16, Issue 10, Page 1929-1940, October 2025.
This study employed a two‐sample Mendelian randomization approach to assess the causal relationship between autoimmune liver diseases (AILD) and diabetes mellitus. We found that genetic predispositions to primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC) were significantly associated with an increased risk of type 1 diabetes ...
Haixia Kuang, Jian Wu, Tao Huang, Kai Yan, Xiaoyun Hu, Ying Wu, Yudi Wang, Zhihong Wu, Xiao Chen, Gaole Yuan   +9 more
wiley   +1 more source

Primary biliary cirrhosis in classmates [PDF]

, 2002
Two former classmates aged 58 with a history of more than 20 years of elevated liver function tests presented to our clinic. As they were both tested positive for antimitochondrial antibodies and liver biopsy showed distinctive bile duct lesions, they ...
Mach, Marc-Alexander von
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