Results 21 to 30 of about 6,678 (215)

Antimony resistant Leishmania donovani but not sensitive ones drives greater frequency of potent T-regulatory cells upon interaction with human PBMCs: role of IL-10 and TGF-β in early immune response. [PDF]

PLoS Neglected Tropical Diseases, 2014
In India the sand fly, Phlebotomus argentipes, transmitted parasitic disease termed kala-azar is caused by Leishmania donovani (LD) in humans. These immune-evading parasites have increasingly developed resistance to the drug sodium antimony gluconate in ...
Rajan Guha, Shantanabha Das, June Ghosh, Shyam Sundar, Jean Claude Dujardin, Syamal Roy   +5 more
doaj   +1 more source

Runx proteins mediate protective immunity against Leishmania donovani infection by promoting CD40 expression on dendritic cells.

PLoS Pathogens, 2020
The level of CD40 expression on dendritic cells (DCs) plays a decisive role in disease protection during Leishmania donovani (LD) infection. However, current understanding of the molecular regulation of CD40 expression remains elusive.
Md Naushad Akhtar, Manish Mishra, Vinod Yadav, Manisha Yadav, Ravindra Gujar, Sunaina Lal, Raj Kumar, Neeraj Khatri, Pradip Sen   +8 more
doaj   +1 more source

Comparison of treatment regimens of kala-azar based on culture & sensitivity of amastigotes to sodium antimony gluconate.

The Indian journal of medical research, 2008
Present treatment strategies for kala-azar (visceral leishmaniasis, VL) include use of first line drug sodium antimony gluconate (SAG) to all patients but a large number of patients do not get relief with this drug. If a patient does not respond to a full course of SAG, a second or third line drug is given.
C.P. Thakur, Shabnam Thakur, Shyam Narayan, Arun K. Sinha   +3 more
openalex   +2 more sources

Quantification of parasite load in clinical samples of leishmaniasis patients: IL-10 level correlates with parasite load in visceral leishmaniasis. [PDF]

PLoS ONE, 2010
A rapid and accurate method to detect and quantify Leishmania parasite is urgently needed to facilitate early diagnosis of leishmaniasis and monitoring of antileishmania therapy.
Sandeep Verma, Rajesh Kumar, Gajendra Kumar Katara, Laishram Chandreshwor Singh, Narender Singh Negi, V Ramesh, Poonam Salotra   +6 more
doaj   +1 more source

Over-Expression of Cysteine Leucine Rich Protein Is Related to SAG Resistance in Clinical Isolates of Leishmania donovani. [PDF]

PLoS Neglected Tropical Diseases, 2015
BACKGROUND:Resistance emergence against antileishmanial drugs, particularly Sodium Antimony Gluconate (SAG) has severely hampered the therapeutic strategy against visceral leishmaniasis, the mechanism of resistance being indistinguishable.
Sanchita Das, Priyanka Shah, Rati Tandon, Narendra Kumar Yadav, Amogh A Sahasrabuddhe, Shyam Sundar, Mohammad Imran Siddiqi, Anuradha Dube   +7 more
doaj   +1 more source

Improved kala-azar case management through implementation of health facility-based sentinel sites surveillance system in Bihar, India.

PLoS Neglected Tropical Diseases, 2021
BackgroundVisceral leishmaniasis (VL), also known as kala-azar (KA), is a neglected vector-borne disease, targeted for elimination, but several affected blocks of Bihar are posing challenges with the high incidence of cases, and moreover, the disease is ...
Vidya Nand Rabi Das, Niyamat Ali Siddiqui, Gouri Sankar Bhunia, Krishna Pandey, Sanjay Kumar Sinha, Md Zahid Ansari, Roshan Kamal Topno, Chandra Sekhar Lal, Alok Ranjan, Vijay Pratap Singh, Pradeep Das   +10 more
doaj   +1 more source

A randomized comparison of branded sodium stibogluconate and generic sodium stibogluconate for the treatment of visceral leishmaniasis under field conditions in Sudan. [PDF]

, 2000
OBJECTIVE: To compare the outcome of treatment of Sudanese kala-azar patients treated under field conditions with either branded sodium stibogluconate (SSG) (Pentostam GlaxoWellcome) or generic SSG (Albert David Ltd, Calcutta, supplied by International ...
Davidson, R N, Ritmeijer, K, Seaman, J, Veeken, H   +3 more
core   +2 more sources

Cutaneous leishmaniasis

Journal of Pathology of Nepal, 2017
Leishmaniasis is considered to be zoonotic disease, caused by a protozoan parasite of the genus Leishmania, and transmitted by a bite of infected female sandfly.
Ram Chandra Adhikari, Mahesh Shah
doaj   +1 more source

Jriostarn (trivalent sodium antimony gluconate) による日本住血吸虫症の治療について

The KITAKANTO Medical Journal, 1956
秀浄 大田
semanticscholar   +3 more sources

The overexpression of genes of thiol metabolism contribute to drug resistance in clinical isolates of visceral leishmaniasis (kala azar) in India

Parasites & Vectors, 2014
Background Visceral leishmaniasis (VL), also called Kala Azar (KA) or black fever in India, claims around 20,000 lives every year. Chemotherapy remains one of the most important tools in the control of VL.
Neeloo Singh, Mitali Chatterjee, Shyam Sundar   +2 more
doaj   +1 more source