Results 171 to 180 of about 2,758 (202)
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Antimutagenic effects of polyphenolic compounds
Cancer Letters, 1992Smokers expose themselves to potent carcinogens daily. One of them is the nicotine-derived nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Since estimates are that humans consume 1 g of phenolic compounds/day, we investigated the inhibitory effects of five structurally related polyphenolic compounds on the mutagenicity of NNK in ...
R W, Teel, A, Castonguay
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Antimutagenic effects in humans
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1992The application of antimutagenicity studies to human somatic mutation is discussed, with emphasis on the potential for future studies. Five assay-gene combinations are now available for measuring human somatic mutation in lymphocytes and erythrocytes. Results with these combinations have defined the human background levels, and show clear responses of ...
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Antimutagenic Effects of Chlorophyllin
1990It has been suggested that the majority of human cancers are caused by environmental exposures, but little is known about the effective environmental and occupational risks of cancer. It is likely that the process of mutagenesis and the intricate balance between mutagenesis and antimutagenesis are involved in aging, evolution, and other fundamental ...
G, Bronzetti, A, Galli, C, Della Croce
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Antioxidants/antimutagens in food
Critical Reviews in Food Science and Nutrition, 1990Oxygen is indispensable for aerobic organisms including, of course, human beings, but it is believed that oxygen also may be responsible for undesired phenomena. In particular, oxygen species such as hydrogen peroxide, superoxide radical anion, and singlet oxygen are proposed as agents attacking polyunsaturated fatty acids in cell membranes, giving ...
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Journal of Natural Products, 1989
Intricatin [1] and intricatinol [2] are new homoisoflavonoids isolated from a desert plant Hoffmanosseggia intricata, which was collected in Baja California, Mexico. The structures of the compounds were elucidated using a variety of spectroscopic techniques.
M E, Wall +4 more
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Intricatin [1] and intricatinol [2] are new homoisoflavonoids isolated from a desert plant Hoffmanosseggia intricata, which was collected in Baja California, Mexico. The structures of the compounds were elucidated using a variety of spectroscopic techniques.
M E, Wall +4 more
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Vitamins as antimutagens: Advantages and some possible mechanisms of antimutagenic action
Mutation Research/Reviews in Mutation Research, 1997Dietary natural inhibitors of mutagenesis and carcinogenesis are of particular importance because they may be useful for human cancer prevention and do not have undesirable xenobiotic effects on living organisms. As was shown in numerous experiments, many endogenous substances, usually obtained in food or synthesized by cells, possess some inhibitory ...
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Antimutagenic properties of ubiquinone-10
Bulletin of Experimental Biology and Medicine, 1994The effect of biotechnologically obtained ubiquinone-10 on the level of photrin- and dioxydin-induced chromosomal aberrations is studied for different doses of the preparations by assessing chromosomal aberrations in bone marrow cells of C57B1/6 mice. It is shown that ubiquinone-10 does not exhibit its own mutagenic effect and does not potentiate the ...
V N, Georgiev +2 more
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Antimutagenic Activity of Berry Extracts
Journal of Medicinal Food, 2004Plants are proven sources of useful anti-tumor and chemopreventative compounds. Hence, identification of phytochemicals useful in dietary prevention and intervention of cancer is of paramount importance. The initial step in the formation of cancer is damage to the genome of a somatic cell producing a mutation in an oncogene or a tumor-suppressor gene ...
S, Hope Smith +6 more
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Plant Antimutagenic Agents, 3. Coumarins
Journal of Natural Products, 1988Several coumarins were isolated from crude plant extracts by means of an antimutagenic assay procedure. These coumarins included psoralen from Psoralea corylifolia and imperatorin and osthol from Selinum monniere. Studies of structure-activity relationships of these and several other available coumarins were carried out with four mutagens.
M E, Wall +6 more
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Antimutagens from Plumeria acuminata Ait
Mutation Research/Environmental Mutagenesis and Related Subjects, 1996Four isolates, A1, C1, D3, and F2, from the ethanol extract of the green leaves of Plumeria acuminata Ait, showed antimutagenic activity. The antimutagens were isolated from the bioactive hexane and carbon tetrachloride fractions following a bioactivity-directed fractionation scheme and using the micronucleus test to monitor the antimutagenic ...
A P, Guevara, E, Amor, G, Russell
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