Results 51 to 60 of about 22,037,861 (287)

A Viscous DES‐AAV‐Foxo1 Delivery System With High Transfection Efficiency for the Treatment of Corneal Endothelial Dysfunction by Restoring Mitochondria‐ER Contacts

Advanced Science, EarlyView.
High glucose triggers corneal endothelial dysfunction by impairing FOXO1‐mediated ITPR1 transcription, leading to disrupted mitochondria‐associated membrane (MAM) integrity and defective ER‐to‐mitochondria Ca2+ transfer. This study develops an innovative viscous DES‐AAV‐Foxo1 delivery system with enhanced transfection efficiency. This non‐invasive gene
Hongran Zhao, Xiaoyu Li, Hongwei Wang, Zongyi Li, Qun Wang, Yangyang Zhang, Xu Jing, Xia Qi, Qingjun Zhou, Shengqian Dou, Lixin Xie   +10 more
wiley   +1 more source

The efficacy of the anticancer 3-bromopyruvate is potentiated by antimycin and menadione by unbalancing mitochondrial ROS production and disposal in U118 glioblastoma cells

Heliyon, 2020
Metabolic reprogramming of tumour cells sustains cancer progression. Similar to other cancer cells, glioblastoma cells exhibit an increased glycolytic flow, which encourages the use of antiglycolytics as an effective complementary therapy.
Maya Petricciuolo, Magdalena Davidescu, Katia Fettucciari, Leonardo Gatticchi, Stefano Brancorsini, Rita Roberti, Lanfranco Corazzi, Lara Macchioni   +7 more
doaj   +1 more source

ANTIMYCIN A COMPONENTS. I

The Journal of Antibiotics, 1970
Antimycin A is a complex of four major components designated as A1, A2, A3 and A4, which were isolated, A4 for the first time, in pure crystalline form. All components exhibited the same fungicidal activity, using Saccharomyces cerevisiae Y-30 as the test organism ; the higher activity of A3 reported before was found to be only apparent, and could be ...
DIETER KLUEPFEL, SURENDRA N. SEHGAL, CLAUDE VÉZINA   +2 more
openaire   +2 more sources

Brown Adipocyte Sheets Alleviate Myocardial Ischemia–Reperfusion Injury Through NRG4–ErbB4–Dependent Ferroptosis Inhibition

Advanced Science, EarlyView.
Brown adipocyte sheets are engineered to protect the heart against myocardial ischemia–reperfusion injury by restraining ferroptosis. Upon transplantation onto the cardiac surface, they improve cardiac function, limit infarction and fibrosis, and enhance angiogenesis.
Lifu Sun, Yuting Liu, Jingbo Zhang, Takuji Kawamura, Junjun Li, Li Liu, Shigeru Miyagawa   +6 more
wiley   +1 more source

Salicylic Acid-Induced Resistance to Cucumber mosaic virus in Squash and Arabidopsis thaliana: Contrasting Mechanisms of Induction and Antiviral Action

Molecular Plant-Microbe Interactions, 2005
Salicylic acid (SA)-induced resistance to Cucumber mosaic virus (CMV) in tobacco (Nicotiana tabacum) results from inhibition of systemic virus movement and is induced via a signal transduction pathway that also can be triggered by antimycin A, an inducer
Carl N. Mayers, Kian-Chung Lee, Catherine A. Moore, Sek-Man Wong, John P. Carr   +4 more
doaj   +1 more source

Mitochondrial Electron Transport Chain Complex III Is Required for Antimycin A to Inhibit Autophagy

Chemistry and Biology, 2011
Autophagy is a cellular lysosome-dependent catabolic mechanism mediating the turnover of intracellular organelles and long-lived proteins. Dysfunction of autophagy has been implicated in multiple human diseases.
Xiuquan Ma, Mingzhi Jin, Yu Cai, Hongguang Xia, Kai Long, Junli Liu, Qiang Yu, Junying Yuan   +7 more
semanticscholar   +1 more source

Xenogeneic Mitochondrial Transplantation Improves Selected Age‐Associated Phenotypes in Mice

Advanced Science, EarlyView.
Yak‐derived xenogeneic mitochondrial transplantation improves selected age‐associated phenotypes in mice, enhances mitochondrial functional readouts, and engages host mitochondrial quality‐control pathways. Broad tissue biodistribution, increased ATP production and mtDNA copy number, reduced ROS levels and dysfunctional mitochondria, improved motility ...
Wenpeng Li, Xijia Wang, Yaning Hu, Zhen Yang, Tian Niu, Xingbo Zhao   +5 more
wiley   +1 more source

Antimycin A, but not antimycin A3 or myxothiazol, directly suppresses photosystem II activity

Bioscience, Biotechnology, and Biochemistry
Abstract Antimycin A (AA) is a widely used inhibitor to study photosynthesis and respiration. In photosynthesis, it is commonly used to inhibit a pathway of cyclic electron flow around photosystem I (CEF-PSI), but has also been reported to affect photosystem II (PSII), not involved in CEF-PSI.
Ko Imaizumi, Kentaro Ifuku
openaire   +2 more sources

Mitochondrial Carrier SLC25A13 Drives Ferroptosis Resistance and Immune Evasion via a STAT3–IFI6 Circuit in Breast Cancer

Advanced Science, EarlyView.
SLC25A13 is identified as an immunometabolic driver of triple‐negative breast cancer that sustains ferroptosis resistance and immune evasion through a STAT3–IFI6 circuit. Pharmacologic degradation of SLC25A13 restores ferroptosis sensitivity and enhances anti‐PD‐1 efficacy, highlighting a strategy to convert immune‐cold tumors into immunotherapy ...
Yingze Zhu, Yuhan Tang, Yingcui Chen, Zhuoqi Zhang, Yige Lu, Xinyue Wang, Qiyuan Shi, Wenhui Zhao, Hui Pang   +8 more
wiley   +1 more source

Dose Dependence of the Separate and Combined Impact of Copper-Oxide and Selenium-Oxide Nanoparticles on Oxygen Consumption by Cells With or Without the Background Action of Some Modulators of the Mitochondrial Respiratory Function

Dose-Response, 2023
We had previously demonstrated on various stable cell cultures exposed to chemically different nanoparticles when assessing their cytotoxicity by different outcomes, dose-response relationships may be either monotonic or non-monotonic falling within an ...
Tatiana V. Bushueva, Vladimir G. Panov, Ilzira A. Minigalieva, Larisa I. Privalova, Maria S. Vedernikova, Vladimir B. Gurvich, Marina P. Sutunkova, Boris A. Katsnelson   +7 more
doaj   +1 more source