Results 41 to 50 of about 29,328 (300)
Characterization of AntB, a Promiscuous Acyltransferase Involved in Antimycin Biosynthesis
, 2016 The in vivo and in vitro characterization of AntB, a dedicated acyltransferase encoded in the antimycin biosynthetic gene cluster, which catalyzes the C-8 acyloxy formation is reported.
Wenjun Zhang (685002) +3 more
core +1 more source
Advanced Science, EarlyView.In rheumatoid arthritis, synovial Tregs accumulate but are functionally impaired due to iron overload‐induced ferroptosis. This triggers mitochondrial dysfunction and TXK tyrosine kinase‐mediated signaling, leading to Treg destabilization and inflammation.
Jingrong Chen +19 more
wiley +1 more source
Discovery of potent broad spectrum antivirals derived from marine actinobacteria.
PLoS ONE, 2013 Natural products provide a vast array of chemical structures to explore in the discovery of new medicines. Although secondary metabolites produced by microbes have been developed to treat a variety of diseases, including bacterial and fungal infections ...
Avi Raveh +10 more
doaj +1 more source
H+ production by antimycin-inhibited mitochondria [PDF]
Biochemical Journal, 1982 1. Oxygen-pulse experiments on antimycin-treated liver mitochondria from young rats in the absence of added substrates indicate the presence of an endogenous hydrogenated reductant on the oxygen side of the antimycin inhibition site. This reductant has been estimated to be present in a 20-50-fold molar excess over cytochrome aa3.
J M, Wrigglesworth, P, Nicholls
openaire +2 more sources
, 2005 To examine the role of mitogen-activated protein kinase kinase 3 (MKK3) and p38 mitogen-activated protein kinase (p38-MAPK) in the cardioprotection afforded by antimycin A.
Quinlan, R A +18 more
core +1 more source
Advanced Science, EarlyView.In this article, Shuai and colleagues demonstrate that metabolic remodeling drives self‐diploidization in murine haploid ESCs (haESCs). Mitochondrial dysfunction and imbalanced pyruvate metabolism underlie this process. Genome‐wide screening using haESCs identifies key mitochondrial quality‐control related genes, enabling a metabolism‐based medium that
Yi Fu +11 more
wiley +1 more source
Inhibition of electron transport of rat liver mitochondria by unnatural (-)-antimycin A3
, 1991 The inhibition of electron transport by unnatural (-)-antimycin A3 was examined with rat liver mitochondria and compared with that of natural (+)-antimycin A3. (−)-Antimycin A3 inhibited respiration about 1/100th as strongly as natural (+)-antimycin A3. (
Iwamura, Hajime +4 more
core +1 more source
Advanced Science, EarlyView.We developed a nanoparticle named OAF, which simultaneously targeted to both the brain and liver via the transferrin receptor 1 (TfR1) receptor, promoting lipoprotein receptor‐related protein 1 (LRP1) expression to enhance amyloid‐beta (Aβ) clearance. In AD mice model, OAF significantly reduced Aβ deposition and cognitive impairment, while a mitigating
Wenshuai Gong +8 more
wiley +1 more source
Platelets, 2022 Platelets have an active energy metabolism mediated by mitochondria. However, the role of mitochondria in platelet adhesion, activation, and thrombus formation under blood flow conditions remains to be elucidated.
Noriko Tamura +3 more
doaj +1 more source
Mitochondrial Electron Transport Chain Complex III Is Required for Antimycin A to Inhibit Autophagy
, 2011 SummaryAutophagy is a cellular lysosome-dependent catabolic mechanism mediating the turnover of intracellular organelles and long-lived proteins. We show that antimycin A, a known inhibitor of mETC complex III, can inhibit autophagy.
Kai Long +15 more
core +1 more source