Results 141 to 150 of about 14,174 (200)

Landscaping the Nitazene Scaffold to Identify Novel Mu-Opioid Receptor Modulators: From Molecular Design and Chemical Synthesis to Pharmacological Profiling. [PDF]

J Med Chem
Upadhyay N, Neel LT, Li E, Silte AA, Lyu R, Selley DE, Dewey WL, Zhang Y, Pagare PP.   +8 more
europepmc   +1 more source

Structural basis of opioid receptor activation by PCP and ketamine. [PDF]

Nat Struct Mol Biol
Jiang Q, Han J, Fine EJ, Ramos-Gonzalez N, Rangari VA, Ruiz MV, Critz ML, Suomivuori CM, Wang J, Albert TL, Whiddon K, Li K, Robertson MJ, Huang XP, Land BB, Majumdar S, Fay JF, Dror RO, Che T.   +18 more
europepmc   +1 more source

Preclinical Assessment of a Metformin-Melatonin Combination: Antinociceptive Synergism. [PDF]

Pharmaceutics
Gauthereau-Torres MY, Martínez-Guillen JS, Cervantes-Durán C, Gutiérrez-García CJ, Godínez-Hernández D, Aguilera Méndez A, Ortega-Varela LF.   +6 more
europepmc   +1 more source

Some of the next articles are maybe not open access.

Related searches:

Antinociceptive Profile of Hodgkinsine

Planta Medica, 2000
To further understand the mechanism of analgesic activity and structural requirements of pyrrolidinoindoline alkaloids identified in Psychotria colorata, we here report the analgesic activity of the trimer hodgkinsine on thermal and chemical models of analgesia.
T. Amador, L. Verotta, D. S. Nunes, E. Elisabetsky   +3 more
openaire   +3 more sources

Topical clonidine antinociception

Pain, 2004
Clonidine, an alpha-2 adrenergic agonist, is an extremely potent antinociceptive agent. However, the therapeutic utility of systemic clonidine for the treatment of pain is limited by centrally mediated side effects including sedation, hypotension and rebound hypertension.
Ahmet, Dogrul, Tayfun I, Uzbay
openaire   +2 more sources

The antinociceptive effect of fluvoxamine

European Neuropsychopharmacology, 1996
The authors conducted a study in order to evaluate the antinociceptive effects of the serotonin-selective reuptake inhibitor (SSRI) antidepressant fluvoxamine and its interaction with various opioid receptor subtypes. Male ICR mice were tested with a hotplate analgesia meter.
S, Schreiber, M M, Backer, J, Yanai, C G, Pick   +3 more
openaire   +2 more sources

Atropine Reverses the Antinociception of Nonsteroidal Anti-Inflammatory Drugs in the Tail-Flick Test of Mice [PDF]

Pharmacology Biochemistry and Behavior, 2003
The nonsteroidal anti-inflammatory drugs (NSAIDs) clonixin, diclofenac, piroxicam, ketoprofen, meloxicam, and paracetamol induced antinociception after intraperitoneal or intrathecal administration in mice submitted to an acute thermal algesiometric test
H F Miranda, G Pinardi, F Sierralta
exaly   +2 more sources

Substance P and antinociception

Peptides, 1983
Substance P (SP)-induced antinociception is still a topic of controversy. Some investigators have failed to see an antinociceptive effect of SP, particularly following intraperitoneal administration. In the present experiments SP induced significant hot plate antinociception in male mice, following intraperitoneal administration.
M E, Hall, J M, Stewart
openaire   +2 more sources

Antinociceptive (aminoalkyl)indoles

Journal of Medicinal Chemistry, 1991
The (aminoalkyl)indole (AAI) derivative pravadoline (1a) inhibited prostaglandin (PG) synthesis in mouse brain microsomes in vitro and ex vivo and exhibited antinociceptive activity in several rodent assays. In vitro structure-activity relationship studies of this new class of PG synthesis inhibitors revealed a correspondence in three respects to those
M R, Bell, T E, D'Ambra, V, Kumar, M A, Eissenstat, J L, Herrmann, J R, Wetzel, D, Rosi, R E, Philion, S J, Daum, D J, Hlasta   +9 more
openaire   +2 more sources