Results 161 to 170 of about 14,174 (200)

Descending antinociception and fibromyalgia

Zeitschrift f�r Rheumatologie, 1998
The hypothesis is discussed that a dysfunction of the descending antinociceptive system may underly the pain of fibromyalgia. Data from animal experimentation show that an interruption of the system by spinal cord cooling leads to (1) increase in ongoing activity, (2) lowering in stimulation threshold, and (3) increase in response magnitude in ...
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Synthesis and antinociceptive activity of pyrrolidinylnaphthalenes

Bioorganic & Medicinal Chemistry, 2000
In this paper the synthesis of the racemates (2R,3S/2S,3R)-1,2-dimethyl-3-[2-(6-substituted naphthyl)]-3-hydroxypyrrolidine 1b-d [(2R,3S/2S,3R)-1b-d] are reported. Compounds 1b-d were prepared by reaction of the racemic 1,2-dimethyl-3-pyrrolidone 2 with the lithiation product obtained from 2-bromo-6-substituted naphthalene 3b-d.
COLLINA, SIMONA, AZZOLINA, ORNELLA, BARBIERI, ANNALISA, LANZA, ENRICA, Vercesi D., Sbacchi M., Scheideler M. A., Ghislandi V.   +7 more
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Antinociceptive mechanism of l-DOPA

Pain, 2004
The mechanism of L-DOPA for antinociception was investigated. Nociceptive behaviors in mice after an intrathecal (i.t.) administration of substance P were evaluated. L-DOPA (i.t.) dose-dependently attenuated the substance P-induced nociceptive behaviors.
Takao, Shimizu, Shin-ichi, Iwata, Hirofumi, Morioka, Takasi, Masuyama, Takeo, Fukuda, Masahiro, Nomoto   +5 more
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Antinociceptive activity of midazolam in sheep

Journal of Veterinary Pharmacology and Therapeutics, 1995
The purpose of this study was to examine the effects of midazolam on the nociceptive threshold responses in sheep. The intravenous administration of midazolam (0. 1–0.3 mg/kg) produced a significant dose‐dependent elevation of the mechanical and thermal nociceptive thresholds.
A E, Kyles, A E, Waterman, A, Livingston
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Antinociceptive Constituents of Auricularia polytricha

Planta Medica, 2002
Ceramide (1), cerevisterol (3β,5α,6β-trihydroxyergosta-7,22-diene) (2) and 9-hydroxycerevisterol (3β,5α,6β,9α-tetrahydroxy-ergosta-7,22-diene) (3) were isolated from the CH 2 Cl 2 extract and cerebroside (4) was isolated from the MeOH extract of the fruiting bodies of Auricularia polytricha and identified as the antinociceptive components using the ...
Kiyotaka, Koyama, Michiko, Akiba, Tooru, Imaizumi, Kaoru, Kinoshita, Kunio, Takahashi, Akira, Suzuki, Shingo, Yano, Syunji, Horie, Kazuo, Watanabe   +8 more
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The antinociceptive effect of Salvinorin A in mice

European Journal of Pharmacology, 2006
Salvia divinorum is a hallucinogenic plant used by the Mazatec Indians of Mexico for traditional spiritual ceremonies. The active constituent, salvinorin A, induces profound hallucinations, however the biological mechanism for this action is not known. Affinity-binding studies suggest that the biologic activity of salvinorin A involves the kappa-opioid
Trentini F, John, Larry G, French, Joseph S, Erlichman   +2 more
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Antinociceptive activity of Helicteres isora

Fitoterapia, 2007
Helicteres isora root extracts were studied for antinociceptive activity on acetic acid-induced writhing test in mice, at a dose of 250 mg/kg. Petroleum ether, chloroform and aqueous ethanol extracts have shown significant activity.
Sama, Venkatesh, K Sai, Laxmi, B Madhava, Reddy, M, Ramesh   +3 more
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Antinociceptive effects of clebopride in the mouse

General Pharmacology: The Vascular System, 1995
1. The effects of the substituted benzamide clebopride, an orthopramide, on nociception of chemical and thermal stimuli were investigated. 2. Clebopride (0.5, 1.0 and 2.0 mg/kg) promoted significant analgesia in the tail-flick and hot-plate tests and against abdominal constrictions produced by acetic acid or acetylcholine. 3.
S C, Bittencourt, T C, De Lima, G S, Morato   +2 more
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Antinociceptive and hypothermic effects of trimethyltin

Life Sciences, 1982
Trimethyltin (TMT) induced a dose-dependent antinociceptive and hypothermic effect in mice. Antinociception was not attenuated by naloxone but was reversed by atropine. TMT, however, was ineffective in displacing (3H)-QNB binding in vitro and did not affect (3H)-QNB binding or acetylcholinesterase activity after in vivo administration.
Costa, L. G, Doctor, S. V, Murphy, S. D.
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Green Light Induces Antinociception via Visual-Somatosensory Circuits

Cell Reports, 2023
Zhi Zhang, Wan-Ying Dong, Xiang-Jie Song
exaly