Results 151 to 160 of about 14,174 (200)
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Arylformamidines with antinociceptive properties
Journal of Medicinal Chemistry, 1988A series of formamidines structurally related to clonidine were synthesized and investigated as potential nonopiate analgesics. Several of these compounds showed potent analgesic activity (ED50 on HCl writhing less than 1.0 mg/kg) with low potential for hypotensive effects. A qualitative description of the structure-activity relationship of this series
M, Gall +4 more
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Sildenafil produces antinociception and increases morphine antinociception in the formalin test
European Journal of Pharmacology, 2000The antinociceptive activity of an inhibitor of phosphodiesterase 5 alone or combined with morphine was assessed in the formalin test. Local administration of 1-[4-ethoxy-3-(6, 7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo [3, 4-d]pyrimidin-5-yl)phenylsulfonyl]-4-methyl piperazine (sildenafil, inhibitor of phosphodiesterase 5) produced a dose-dependent
T, Mixcoatl-Zecuatl +2 more
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Gabaergic mechanisms in antinociception
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 1984GABAergic mechanisms appear to be involved in antinociceptive processes. Generally, peripheral administration of GABAergic agents increases the antinociceptive effect of morphine, but central administration inhibits this effect, suggesting that multiple interactions may occur. GABAergic agents also can produce antinociception directly.
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Neuroscience Letters, 1981
Intraventricularly administered acetylcholine inhibits mouse tail-flick latency in a dose-dependent manner with an ED50 of about 20 microgram. This antinociceptive activity is not mimicked by biogenic amine neurotransmitters (i.e. norepinephrine, epinephrine, dopamine, serotonin or histamine) and is not markedly affected by selective depletors of brain
N W, Pedigo, W L, Dewey
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Intraventricularly administered acetylcholine inhibits mouse tail-flick latency in a dose-dependent manner with an ED50 of about 20 microgram. This antinociceptive activity is not mimicked by biogenic amine neurotransmitters (i.e. norepinephrine, epinephrine, dopamine, serotonin or histamine) and is not markedly affected by selective depletors of brain
N W, Pedigo, W L, Dewey
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Nocistatin—A New Antinociceptive Peptide
Regional Anesthesia and Pain Medicine, 200010.1053/rapm.2000.7623 ; Regional Anesthesia and Pain Medicine ; 25 ; 4 ; 408-410 ...
Lee, T.-L., Tachibana, S.
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Opioid antinociception in amphibians
Brain Research Bulletin, 1988Systemic and spinal administration of opioids produces a behaviorally defined antinociception in a variety of mammalian models. Although endogenous opioid peptides and opioid binding sites are ubiquitous throughout phylogeny, little attention has been paid to the function of endogenous opioid system(s) or development of nociceptive models in ...
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5-Hydroxytryptamine and antinociception
Neuropharmacology, 1984The considerable evidence supporting a role for 5-hydroxytryptamine (5-HT) in the modulation of nociceptive thresholds is reviewed. The postulate that an antinociceptive system of neurones projects from periaqueductal gray (PAG) to nucleus raphe magnus (NRM) and then to the dorsal horn, via cells containing 5-HT, has proved difficult to support ...
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Anesthesia & Analgesia, 2003
In this study, we investigated the antinociceptive and sedative effects of the opioids fentanyl, morphine, and oxycodone given alone and in combination with two neurosteroids: alphadolone and alphaxalone. An open-field activity monitor and rotarod apparatus were used to define the sedative effects caused by opioid and neurosteroid compounds given alone
L, Winter +3 more
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In this study, we investigated the antinociceptive and sedative effects of the opioids fentanyl, morphine, and oxycodone given alone and in combination with two neurosteroids: alphadolone and alphaxalone. An open-field activity monitor and rotarod apparatus were used to define the sedative effects caused by opioid and neurosteroid compounds given alone
L, Winter +3 more
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Antinociceptive activity of coniine in mice
Journal of Ethnopharmacology, 2009Hemlock was used as an analgesic in certain ethnopharmacological traditions and there has been no record about the antinociceptive effect of coniine which is the major alkaloid compound of Hemlock.The present study was undertaken to evaluate the possible antinociceptive activity of coniine.Antinociceptive activity of coniine was tested dose in Hotplate
İSKİT, ALPER BEKTAŞ +3 more
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Possible mechanisms of insulin antinociception
Methods and Findings in Experimental and Clinical Pharmacology, 2004The antinociceptive mechanisms of insulin are not clearly understood. It has been postulated that insulin may act as a neuromodulator. The present study investigates the possible mechanisms of insulin antinociception in mice using the tail flick test. Healthy Swiss male albino mice were treated with insulin and the antinociceptive effect of modulators ...
K, Anuradha, D, Hota, P, Pandhi
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