Results 61 to 70 of about 497,025 (343)

NFE2-Related transcription factor 2 coordinates antioxidant defense with thyroglobulin production and iodination in the thyroid gland [PDF]

, 2018
Background: The thyroid gland has a special relationship with oxidative stress. While generation of oxidative substances is part of normal iodide metabolism during thyroid hormone synthesis, the gland must also defend itself against excessive oxidation ...
Amendola, Elena, Bongiovanni, Massimo, Carrasco, Nancy, Chartoumpekis, Dionysios V, Habeos, Ioannis, Juvenal, Guillermo Juan, Kensler, Thomas W., Liao, Xiao-Hui, Ntalampyra, Eleni, Refetoff, Samuel, Renaud, Cédric O., Ris Stalpers, Carrie, Rossich, Luciano Esteban, Santisteban, Pilar, Somm, Emmanuel, Sykiotis, Gerasimos P., Thomasz, Lisa, Trougakos, Ioannis P, Yamamoto, Masayuki, Ziros, Panos G   +19 more
core   +1 more source

Bacillus siamensis Reduces Cadmium Accumulation and Improves Growth and Antioxidant Defense System in Two Wheat (Triticum aestivum L.) Varieties

Plants, 2020
Bioavailability of cadmium (Cd) metal in the soils due to the scarcity of good quality water and industrial waste could be the major limiting factor for the growth and yield of crops.
Samrah Afzal Awan, N. Ilyas, I. Khan, M. Raza, A. Rehman, M. Rizwan, A. Rastogi, Rezwan Tariq, M. Brestič   +8 more
semanticscholar   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Priming of Plant Defenses against Ophiostoma novo-ulmi by Elm (Ulmus minor Mill.) Fungal Endophytes

Journal of Fungi, 2021
Some fungal endophytes of forest trees are recognized as beneficial symbionts against stresses. In previous works, two elm endophytes from the classes Cystobasidiomycetes and Eurotiomycetes promoted host resistance to abiotic stress, and another elm ...
Clara Martínez-Arias, Juan Sobrino-Plata, Luis Gil, Jesús Rodríguez-Calcerrada, Juan Antonio Martín   +4 more
doaj   +1 more source

Spaceflight modulates gene expression in the whole blood of astronauts [PDF]

, 2016
Astronauts are exposed to a unique combination of stressors during spaceflight, which leads to alterations in their physiology and potentially increases their susceptibility to disease, including infectious diseases.
Barrila, Jennifer, Crabbé, Aurélie, LeBlanc, Carly, Mehta, Satish K, Nickerson, Cheryl A, Ott, C Mark, Pierson, Duane L, Stafford, Phillip   +7 more
core   +2 more sources

Effect of Cadmium Toxicity on Growth, Oxidative Damage, Antioxidant Defense System and Cadmium Accumulation in Two Sorghum Cultivars

Plants, 2020
Heavy metal stress is a leading environmental issue reducing crop growth and productivity, particularly in arid and semi-arid agro-ecological zones. Cadmium (Cd), a non-redox heavy metal, can indirectly increase the production of reactive oxygen species (
Muhammad Jawad Hassan, Muhammad Ali Raza, Sana ur Rehman, M. Ansar, H. Gitari, I. Khan, Muhammad Wajid, Mukhtar Ahmed, Ghulam Abbas Shah, Yan Peng, Zhou Li   +10 more
semanticscholar   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Oxidative damage and antioxidative system in algae

Toxicology Reports, 2019
Reactive oxygen species (ROS) typically produce in algae and act as secondary messengers in numerous cellular processes. Under abiotic stresses, the balance between production and suppression of ROS disappears and causes increase of ROS.
Maryam Rezayian, Vahid Niknam, Hassan Ebrahimzadeh   +2 more
doaj   +1 more source

Antioxidant Defenses in the Human Eye: A Focus on Metallothioneins

Antioxidants, 2021
The human eye, the highly specialized organ of vision, is greatly influenced by oxidants of endogenous and exogenous origin. Oxidative stress affects all structures of the human eye with special emphasis on the ocular surface, the lens, the retina and ...
Ana Álvarez-Barrios, Lydia Álvarez, Montserrat García, Enol Artime, Rosario Pereiro, Héctor González-Iglesias   +5 more
doaj   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source