Results 141 to 150 of about 7,172,362 (315)

Potential Antioxidant and Angiotensin I-converting Enzyme Inhibitory Activity in Crust of Dry-aged Beef

, 2020
Antioxidant activity, angiotensin I-converting enzyme (ACE) inhibitory activity, and protein profile of crust (the dried surface of dry-aged beef) were evaluated compared to unaged, wet-, and dry-aged beef.
Lee, Hyun Jung, Choe, Juhui, Park, Bumjin, Jo, Cheorun   +3 more
core   +1 more source

Ultrasound‐Activatable Piezoelectric Hydrogel Reprograms Mitochondrial Epigenetics for Osteoarthritis Therapy via the mTOR/GATD3A Axis

Advanced Science, EarlyView.
An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.
Hui Zheng, Pengfei Yan, Peng Liu, Chang Yan, Mengqi Zhao, Zuyong Wang, Chao Ma, Rongkai Zhang, Xi Cui, Swee Hin Teoh   +9 more
wiley   +1 more source

Trp31 Residue of Trx-1 Is Essential for Maintaining Antioxidant Activity and Cellular Redox Defense Against Oxidative Stress

Thioredoxin-1 (Trx-1) is an important redox protein found in almost all prokaryotic and eukaryotic cells, which has a highly conserved active site sequence: Trp-Cys-Gly-Pro-Cys.
Yi Yan, Xinqiao Liu, Jiaolin Bao, Xijun Guo, Xingzhu Qi, Yuanfeng Fu, Zongmao He, Tong Wang, Ren-Bo Ding   +8 more
core   +1 more source

The Effect of Hydration on Enzyme Activity and Dynamics [PDF]

, 2008
Water has long been assumed to be essential for biological function. To understand the molecular basis of the role of water in protein function, several studies have established a correlation between enzyme activity and hydration level. While a threshold
Lopez, Murielle
core  

Fatty Acid Composition, Steroid Content, In Vitro Antioxidant and Antidiabetic Potentials of Citrullus lanatus and Carica papaya Seed Oils

Biology, Medicine & Natural Product Chemistry
Plant-derived oils rich in bioactive constituents have attracted attention as potential antioxidant and antidiabetic agents. The present study assessed the phytochemical profile, antioxidant activity, enzyme inhibitory activity, and fatty acid profile of
Bamidele Martin Amos-Tautua, Imomotimi Timipa Ajoko, Rafiu Oladiran Raji   +2 more
doaj   +1 more source

Gestational Hypoxia Disrupts Medial Ganglionic Eminence Progenitor Dynamics and Interneuron Development in Schizophrenia

Advanced Science, EarlyView.
FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni, Qiancheng Zhang, Youhui Jiang, Huiying Yao, Chuqing Zhou, Xiaoyi Tian, Shiyingnan Gao, Jun Zhao, Xinyi Ren, Naxin Xu, Mengshan Fu, Liansheng Zhao, Xueyu Qi, Xueli Yu, Wanjun Guo, Sangmi Chung, Fan Guo, Tao Li   +17 more
wiley   +1 more source

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

Advanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou, Jiaxing Huang, Yilin Wang, Xingran Li, Xianyang Liu, Lingyu Dai, Hongshun Li, Qingfeng Wang, Jiangyi Liu, Guannan Su, Wanyun Zhang, Yang Deng, Qingfeng Cao, Yujie Lai, Xiang Luo, Changwei Huang, Ling Chen, Shengping Hou, Peizeng Yang   +18 more
wiley   +1 more source

Putrescine priming effects on chlorophyll fluorescence, antioxidant enzyme activity, and primary metabolite accumulation in maize seedlings under water deficit

This study aimed to evaluate the effect of putrescine priming on the initial growth, chlorophyll fluorescence, primary metabolites accumulation, and antioxidant enzyme activities in two maize hybrids with contrasting drought tolerances. Seeds of Zea mays
C.C. Toledo, G. EsteveS, P.C. Magalhães, L.A.A. Bressanin, A.C.C. Da Silva, T.C. De Souza, M.A. Leite, P.R. Dos Santos-Filho, M.C. Del Peloso   +8 more
core   +1 more source

Study of antioxidant activity of sheep visceral protein hydrolysate: Optimization using response surface methodology

ARYA Atherosclerosis, 2014
BACKGROUND: The main objective of this experiment was optimal use of none edible protein source to increase nutritional value of production with high biological function, including antioxidant activity. METHODS: Sheep visceral (stomach and intestine) was
Nasim Meshginfar, Alireza Sadeghi-Mahoonak, Aman Mohammad Ziaiifar, Mohammad Ghorbani, Mahdi Kashaninejad   +4 more
doaj  

Modification‐Selective Inhibition of Succinate Dehydrogenase a Enables Tumor‐Restricted Mitochondrial Modulation

Advanced Science, EarlyView.
This work identifies acetylation‐dependent SDHA homeostasis as a determinant of tumor‐specific metabolic vulnerability. Guided by this mechanism, a modification‐selective inhibitor, ZPI‐3, selectively targets non‐acetylated SDHA, achieving tumor‐restricted SDH inhibition and effective bladder cancer control. Differential responses in clinical specimens
Kaikai Xu, Lulu Kong, Kebin Ye, Xinlu Bao, Haowen Liu, Ning Wang, Yongming Deng, Wei Wang, Shaohua Wei, Lin Zhou   +9 more
wiley   +1 more source