Results 121 to 130 of about 618,778 (269)

ZDHHC9‐Mediated Palmitoylation of ACSL4 Drives Ferroptosis in Diabetes Mellitus–Induced Erectile Dysfunction

Advanced Science, EarlyView.
ABSTRACT Diabetes mellitus‐induced erectile dysfunction (DMED) is a highly prevalent complication among diabetic patients; however, its underlying pathogenic mechanisms remain incompletely understood. Metabolic disorder is a hallmark of diabetes, yet its precise contribution to DMED progression is not well defined.
Wanyang Guo, Ming Xiao, Mengjun Huang, Dongzi Peng, Ruijiang Zeng, Ruilin Liu, Yuanqiao Zhao, Zhihan Ouyang, Yulong Hong, Zexian Ding, Zhuo Xing, Hao Su, Jinxiang Wang, Wenjun Mao, Xin Jin   +14 more
wiley   +1 more source

Design and Evaluation of a Zingiber officinale–Kaolinite–Maltodextrin Delivery System: Antioxidant, Antimicrobial, and Cytotoxic Activity Assessment

Pharmaceutics
Background/Objectives: Zingiber officinale Roscoe (Zingiberaceae) is widely recognized for its diverse biological activities; however, the stability and bioavailability of its bioactive compounds remain significant challenges.
Adina-Elena Segneanu, Ionela Amalia Bradu, Gabriela Vlase, Titus Vlase, Cornelia Bejenaru, Ludovic Everard Bejenaru, George Dan Mogoşanu, Maria Viorica Ciocîlteu, Dumitru-Daniel Herea, Eugen Radu Boia   +9 more
doaj   +1 more source

Canagliflozin Alleviates Diabetic Glomerular Endothelial Injury via Melibiose in a Microbiota‐Dependent Manner

Advanced Science, EarlyView.
Canagliflozin treatment reshapes the gut microbiota in DKD and elevates levels of melibiose, a metabolite derived from Roseburia intestinalis. Melibiose directly binds to and enhances the enzymatic activity of glyoxalase 1, leading to decreased methylglyoxal accumulation.
Wei Zhang, Yi Song, Changkun Li, Yuanyuan Luo, Mingwei Shao, Feng Guo, Fangyi Wei, Xunjie Fan, Wenwen Guo, Fengmei Xu, Yanhong Sang, Dongming Zhang, Yanhong Zhou, Lianwei Wang, Zhiqiang Kang, Yingjun Yang, Chunhua Song, Yanxia Liu, Xiaojun Ma, Jiao Wang, Chong Li, Shengnan Ma, Lin Zhao, Zhi Qin, Guolan Xing, Qiubo Zhao, Jun Li, Shumin Song, Dan Zhao, Ting Huang, Qingzhu Wang, Yanyan Zhao, Guijun Qin   +32 more
wiley   +1 more source

Phytochemical Profiling and Biological Activities of Extracts from Bioreactor-Grown Suspension Cell Cultures of Schisandra henryi

Molecules
Plant biotechnology creates opportunities for the cultivation of plants regardless of their natural habitats, which are often protected or difficult to access.
Karolina Jafernik, Adam Kokotkiewicz, Michał Dziurka, Aleksandra Kruk, Anna Hering, Krzysztof Jędrzejewski, Piotr Waligórski, Piotr Graczyk, Paweł Kubica, Justyna Stefanowicz-Hajduk, Sebastian Granica, Maria Łuczkiewicz, Agnieszka Szopa   +12 more
doaj   +1 more source

Dual‐Responsive Dynamic Covalent Bond‐Based Assembly of Lipid‐Nanozyme Systems via Multi‐Target Synergy and Efficient Target Enrichment for Ischemic Stroke Therapy

Advanced Science, EarlyView.
This system adopts a biomimetic phospholipid structure, covalently binding iNOS inhibitors, neuroprotective agent PCA and vitamin E derivatives through pH/ROS dual‐responsive bonds, and assembles them with Prussian blue nanozyme to form PBB@AHA. It can efficiently penetrate the blood‐brain barrier and simultaneously release multiple active components ...
Mengcheng Guo, Qingran Guan, Guanyu Qiao, Lixue Zhang, Man Liu, Zhen Li, Qingbiao Yang, Meili Shen, Linlin Liu, Yapeng Li   +9 more
wiley   +1 more source

Kaempferol-Phospholipid Complex: Formulation, and Evaluation of Improved Solubility, In Vivo Bioavailability, and Antioxidant Potential of Kaempferol [PDF]

The current work describes the formulation and evaluation of a phospholipid complex of kaempferol to enhance the latter’s aqueous solubility, in vitro dissolution rate, in vivo antioxidant and hepatoprotective activities, and oral bioavailability.
Darshan R. Telange, Arun T. Patil, Sridhar Anand, Anil M. Pethe, Vivek S. Dave, Amol A. Tatode   +5 more
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Incorporação de nanocápsulas de poli(e-caprolactona) contendo a-tocoferol em biofilmes de metilcelulose [PDF]

, 2012
Dissertação (Mestrado) - Universidade Federal de Santa Catarina, Centro de Ciencias Agrarias, Programa de Pós-Graduação em Ciência dos Alimentos, Florianópolis, 2012O a-tocoferol, isômero da Vitamina E, é um antioxidante natural, amplamente empregado ...
Noronha, Carolina Montanheiro
core  

Biomimetic Ru‐Mn Nanozyme with Cascade Catalytic Activity Attenuates Secondary Brain Injury in Intracerebral Hemorrhage

Advanced Science, EarlyView.
Ru–Mn composite nanozymes are engineered to mimic dual‐enzyme cascade catalysis, enabling efficient ROS clearance and neuroinflammation suppression. In collagenase‐ and autologous blood‐induced ICH mouse models, intranasal and intravenous administration reduced hematoma volume, preserved BBB integrity, and improved neurological recovery.
Zhongxin Duan, Peng Li, Yue Wang, Xin Qi, Wanyu Wang, Yongzhong Cheng, Huabin Zhang, Xin Hu, Xiang Gao   +8 more
wiley   +1 more source

Nutraceutical Content and Biological Properties of Lipophilic and Hydrophilic Fractions of the Phytocomplex from Pistacia atlantica Desf. Buds, Roots, and Fruits

Plants
The aim of the present investigation was to obtain 12 aqueous extracts and 1 oil from Pistacia atlantica Desf. subsp. atlantica specimens. The samples differed for processed plant organs (i.e., roots, buds, and fruits), gender and geographical station of
Nabila Belyagoubi-Benhammou, Larbi Belyagoubi, Assia Benmahieddine, Asma El Zerey-Belaskri, Gabriele Di Marco, Alessia D’Agostino, Antonella Canini, Angelo Gismondi   +7 more
doaj   +1 more source

Nutraceutical evaluation and antioxidant potential of red kidney bean (Phaseolus vulgaris) and chickpea (Cicer arietenum) seed coats [PDF]

, 2019
Legumes have become increasingly in demand due to the rich nutrient compositions and phytochemicals of pulses. However, the seed coats of some legume food products were removed prior consumption causing the food loss its nutritional value. The red kidney
Abd Gani, Siti Salwa, Zaidan, Uswatun Hasanah, Ab Karim, Noria, Halmi, Mohd Izuan Effendi, Ahmad, Syahida   +4 more
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