Arylmethylamino steroids as antiparasitic agents [PDF]
Nature Communications, 2017 In search of antiparasitic agents, we here identify arylmethylamino steroids as potent compounds and characterize more than 60 derivatives. The lead compound 1o is fast acting and highly active against intraerythrocytic stages of chloroquine-sensitive ...
Esther Jortzik +2 more
exaly +13 more sources
Phase I Clinical Trial Results of Auranofin, a Novel Antiparasitic Agent [PDF]
Antimicrobial Agents and Chemotherapy, 2017 James H Mckerrow, Sharon L Reed
exaly +4 more sources
Repurposing Potential of the Antiparasitic Agent Ivermectin for the Treatment and/or Prophylaxis of COVID-19 [PDF]
Pharmaceuticals, 2022 Due to the rapid, vast, and emerging global spread of the Coronavirus Disease 2019 (COVID-19) pandemic, many drugs were quickly repurposed in a desperate attempt to unveil a miracle drug. Ivermectin (IVM), an antiparasitic macrocyclic lactone, was tested
Hoda Awad +5 more
doaj +2 more sources
S-Methyl-(2-Methoxycarbonylamino-Benzimidazole-5) Thiosulfonate as a Potential Antiparasitic Agent—Its Action on the Development of Ascaris suum Eggs In Vitro [PDF]
Pharmaceuticals, 2020 Ascaris suum is a soil-transmitted parasite causing ascariasis in pigs, largely limiting livestock production globally. Searching for new drugs affecting all stages of nematode development is necessary and widely postulated.
Małgorzata Dmitryjuk +6 more
doaj +2 more sources
Investigating the Antiparasitic Potential of the Marine Sesquiterpene Avarone, Its Reduced Form Avarol, and the Novel Semisynthetic Thiazinoquinone Analogue Thiazoavarone [PDF]
Marine Drugs, 2020 The chemical analysis of the sponge Dysidea avara afforded the known sesquiterpene quinone avarone, along with its reduced form avarol. To further explore the role of the thiazinoquinone scaffold as an antiplasmodial, antileishmanial and antischistosomal
Concetta Imperatore +13 more
doaj +3 more sources
Phosphonium lipocations as antiparasitic agents [PDF]
Bioorganic & Medicinal Chemistry Letters, 2012 Phosphonium lipocations were synthesized and evaluated for inhibition of the development of Plasmodium falciparum and Trypanosoma cruzi, etiological agents of malaria and Chagas disease, respectively. Optimal phthalimides and 1,4-naphthoquinone-based lipocations were active in vitro at mid-high nM concentrations against P.
Timothy E. Long +5 more
openalex +4 more sources
The effects of LED Spectra on synthesis of antiparasitic bioactive compound in Eurycoma longifolia hairy root culture against Blastocystis Sp [PDF]
Scientific ReportsEurycoma longifolia (also known as Tongkat Ali) is one of the valuable medicinal plants frequently used as traditional medicine in Malaysia. Its alkaloids and quassinoids reportedly confers antiparasitic activities. The effect of different Light Emitting
Mahmoud Ali Khalaf Abushattal +7 more
doaj +2 more sources
Nitazoxanide: A New Thiazolide Antiparasitic Agent [PDF]
Clinical Infectious Diseases, 2005 Nitazoxanide is a new thiazolide antiparasitic agent that shows excellent in vitro activity against a wide variety of protozoa and helminths. It is given by the oral route with good bioavailability and is well tolerated, with primarily mild gastrointestinal side effects. At present, there are no documented drug-drug interactions.
LeAnne M, Fox, Louis D, Saravolatz
exaly +3 more sources
A Review of FDA-Approved Antiparasitic Drugs in USA for Sheep and Goats: Their Synthesis and Pharmaceutical Use [PDF]
Trends in Pharmaceutical Sciences, 2023 This review describes the Food and Drug Administration (FDA)-approved antiparasitic drugs for sheep and goats in the USA updated to 2021. The emerging drug resistance is posing a significant burden for the treatment of parasitic infections in these small
Davide Benedetto Tiz, Črtomir Podlipnik
doaj +1 more source