Repurposing Potential of the Antiparasitic Agent Ivermectin for the Treatment and/or Prophylaxis of COVID-19 [PDF]
Pharmaceuticals, 2022 Due to the rapid, vast, and emerging global spread of the Coronavirus Disease 2019 (COVID-19) pandemic, many drugs were quickly repurposed in a desperate attempt to unveil a miracle drug. Ivermectin (IVM), an antiparasitic macrocyclic lactone, was tested
Hoda Awad +5 more
doaj +5 more sources
Arylmethylamino steroids as antiparasitic agents [PDF]
Nature Communications, 2017 In search of antiparasitic agents, we here identify arylmethylamino steroids as potent compounds and characterize more than 60 derivatives. The lead compound 1o is fast acting and highly active against intraerythrocytic stages of chloroquine-sensitive ...
Esther Jortzik +2 more
exaly +13 more sources
Repurposing and Reformulation of the Antiparasitic Agent Flubendazole for Treatment of Cryptococcal Meningoencephalitis, a Neglected Fungal Disease. [PDF]
Antimicrob Agents Chemother, 2018 Current therapeutic options for cryptococcal meningitis are limited by toxicity, global supply, and emergence of resistance. There is an urgent need to develop additional antifungal agents that are fungicidal within the central nervous system and ...
Nixon GL +15 more
europepmc +4 more sources
Antitumor effects of the antiparasitic agent ivermectin via inhibition of Yes-associated protein 1 expression in gastric cancer. [PDF]
Oncotarget, 2017 Yes-associated protein 1 (YAP1) acts as an oncogene through dephosphorylation and nuclear translocation, and nuclear accumulation of YAP1 is associated with poor prognosis in gastric cancer (GC). We previously identified ivermectin, an antiparasitic drug,
Nambara S +16 more
europepmc +4 more sources
Antiparasitic Agent Atovaquone [PDF]
Antimicrobial Agents and Chemotherapy, 2002 Atovaquone is a unique naphthoquinone with broad-spectrum antiprotozoal activity. It is effective for the treatment and prevention of Pneumocystis carinii pneumonia (PCP), it is effective in combination with proguanil for the treatment and prevention of malaria, and it is effective in combination with azithromycin for the treatment of babesiosis. There
Aaron L, Baggish, David R, Hill
semanticscholar +5 more sources
Zinc from an Essential Element to an Antiparasitic Therapeutic Agent
ACS OmegaTropical parasitic diseases affect millions of people around the world, particularly in poor countries. The human parasitic diseases that will be covered in this review are malaria and neglected diseases, such as leishmaniasis, Chagas disease, and ...
Maribel Navarro +3 more
doaj +3 more sources
Insight into the mechanism of action of temporin-SHa, a new broad-spectrum antiparasitic and antibacterial agent. [PDF]
PLoS ONE, 2017 Antimicrobial peptides (AMPs) are promising drugs to kill resistant pathogens. In contrast to bacteria, protozoan parasites, such as Leishmania, were little studied. Therefore, the antiparasitic mechanism of AMPs is still unclear.
Zahid Raja +11 more
doaj +4 more sources
Nitazoxanide: A New Thiazolide Antiparasitic Agent [PDF]
Clinical Infectious Diseases, 2005 LeAnne M. Fox, Louis D. Saravolatz
exaly +3 more sources
Study of the toxicity and effectiveness of an antiparasitic agent based on tinidazole and fenbendazole [PDF]
Ukrainian Journal of Ecology, 2020 The development of new import-substituting highly effective and environmentally friendly complex antiparasitic drugs and their implementation in a scientifically grounded system of measures to combat the causative agents of the main invasive diseases of ...
Andriy Paliy +2 more
openalex +2 more sources
S-Methyl-(2-Methoxycarbonylamino-Benzimidazole-5) Thiosulfonate as a Potential Antiparasitic Agent—Its Action on the Development of Ascaris suum Eggs In Vitro [PDF]
Pharmaceuticals, 2020 Ascaris suum is a soil-transmitted parasite causing ascariasis in pigs, largely limiting livestock production globally. Searching for new drugs affecting all stages of nematode development is necessary and widely postulated.
Małgorzata Dmitryjuk +6 more
doaj +2 more sources